Phytochemical identification, acute and subchronic oral toxicity assessments of hydroalcoholic extract of Acroptilon repens in BALB/c mice: A toxicological and mechanistic study

Dashti, Ayat; Shokrzadeh, Mohammad; Karami, Mohammad; Habibi, Emran

doi:10.1016/j.heliyon.2022.e08940

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…Toxicological investigations of bioactive compounds derived from medicinal plants are essential to ensure the safety of using herbs in the treatment of a series of diseases [ 18 ]. Therefore, it is relevant to analyze the acute toxicity generated by treatment with solidagenone in mice.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, no significant variance in body weight was noted among the animals treated with different doses of solidagenone when compared to mice treated only with the vehicle solution (Table 2). Toxicological investigations of bioactive compounds derived from medicinal plants are essential to ensure the safety of using herbs in the treatment of a series of diseases [18]. Therefore, it is relevant to analyze the acute toxicity generated by treatment with solidagenone in mice.…”

Section: Resultsmentioning

confidence: 99%

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Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway

Santos,

Silva,

Silva

et al. 2024

Pharmaceuticals

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Anti-inflammatory agents are widely used for the treatment of inflammatory diseases. Nevertheless, the associated side effects of the available drugs make it necessary to search for new anti-inflammatory drugs. Here, we investigated the anti-inflammatory activity of solidagenone. Initially, we observed that a single dose of 30, 60, or 90 mg/kg of solidagenone did not result in mortality or elicit any discernible signs of toxicity in mice. At the same doses, solidagenone promoted a significant reduction in the migration of neutrophils in an acute peritonitis model and decreased mortality in a lipopolysaccharide-induced endotoxic shock model. Interestingly, treatment with solidagenone conferred a protective effect against leukopenia and thrombocytopenia, hematological disorders commonly observed in sepsis conditions. In addition, treatment with all the doses of solidagenone promoted a significant reduction in nitric oxide, TNF-α, and IL-1β levels relative to the LPS-stimulated vehicle-treated cultures. Furthermore, gene expression and in silico analyses also supported the modulation of the NF-κB pathway by solidagenone. Finally, in silico pharmacokinetics predictions indicated a favorable drugability profile for solidagenone. Taken together, the findings of the present investigation show that solidagenone exhibits significant anti-inflammatory properties in acute experimental models, potentially through the modulation of the NF-κB signaling pathway.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway

Santos,

Silva,

Silva

et al. 2024

Pharmaceuticals

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“…However, the application of many of these compounds in disease treatment is frequently limited by poor absorption and potential toxicity. 15 The extract of B. balsamifera, containing various phytochemical compounds, has been used in traditional medicine. Alkaloids can affect the nervous system and provide pain relief, phenols have antioxidative, antibacterial, and anti-inflammatory effects, flavonoids protect cells from oxidative damage, saponins reduce cholesterol, tannins, terpenoids, and steroids exhibit anti-inflammatory, antibacterial, and immune-regulatory properties.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Acute and Chronic Toxicity Studies of Ethanol Extract of Blumea balsamifera (L.) DC. Leaves on Murine Models

2024

TJNPR

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Species within the Blumea genus are widely distributed across tropical regions of Asia, Africa, and the Pacific, with the highest diversity observed in the tropical Asian region. In recent decades, researchers have concentrated their efforts on studying the species within the Blumea genus that are used in components of the Ayurvedic traditional medical system in India and traditional beverages known as "Loloh". 4 In China, B. balsamifera is utilized as a fragrance due to its high essential oil content. Its entire plant or leaves are employed in traditional Chinese medicine to treat various conditions, including scabies, dermatitis, beriberi, back pain, menstrual pain, arthritis, skin injuries, and even in the formulation of insect repellents. 5 In Thailand, dried leaves of B. balsamifera can be used to make medicinal cigarettes to alleviate symptoms of sinusitis, abdominal pain, and cough, and can even be combined with other plants to create postpartum herbal baths for women. In the Philippines, B. balsamifera serves as a traditional remedy for kidney stones, common colds, and diuretic purposes. Furthermore, in other Asian countries such as Malaysia, B. balsamifera is also incorporated into Ayurvedic traditional medicine systems. 4 While there have been some studies related to the pharmacological effects of B. balsamifera, the safety of ethanol extract from Blumea balsamifera leaves (EEBB) in vivo remains unconfirmed. Based on the traditional use of B. balsamifera, this study was conducted to comprehensively assess the acute and subchronic toxicity of EEBB on an animal model. The results of this research will provide a foundation for utilizing this extract in research and applications for the treatment of arthritis, pain relief, and cancer prevention. Materials and Methods Collection of plant materialThe leaves of the Blumea balsamifera L. (DC.) plant were collected in Cam My district, Dong Nai province, Vietnam (Coordinates: 10°49'26.8"N 107°12'10.8"E), in April 2023. The plant specimen, labeled as BB110423VST, is currently held at the Plant Biotechnology

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“…Acroptilon repens (Asteraceae), or Rhaponticum repens , is a widespread medicinal plant in Mongolia, Iran, Turkey, Armenia, the United States, and Canada. It has been used in traditional medicine as an emetic, antiepileptic, and anti-malaria [ 7 ]. In addition, its Essential oil (EO) polyphenol compounds are responsible for various biological effects such as antileishmanial, antioxidant, antibacterial, antimutagenic, anti-inflammatory, and antilarval activities [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Repellent efficacy of the nanogel containing Acroptilon repens essential oil in comparison with DEET against Anopheles stephensi

Zarenezhad,

Sanei-Dehkordi,

Babaalizadeh

et al. 2023

BMC Res Notes

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Objective Malaria is a vector-borne disease that causes many deaths worldwide; repellents are a practical approach to malaria prevention, especially in endemic regions. Results Gas chromatography-mass spectrometry analysis was used to identify compounds in Acroptilon repens essential oil (EO). Alpha-copaene (15.67%), α-cubenen (3.76%), caryophyllene oxide (14.00%), 1-heptadecane (5.61%), and δ-cadinene (2.84) were five major compounds. After that, the nanoemulsion containing the EO with a particle size of 46 ± 4 nm, SPAN 0.85, PDI 0.4, and zeta potential − 5.7 ± 0.4 mV was prepared. Then, it was gellified by adding CMC (carboxymethyl cellulose) to the nanoemulsion. Besides, ATR-FTIR analysis (Attenuated Total Reflection-Fourier Transform InfraRed) was used to confirm the EO’s successful loading in the nanogel. Finally, the protection time and repellent activity of nanogel compared to DEET (N, N-diethyl-meta-toluamide) were investigated against Anopheles stephensi. Interestingly, the nanogel with a protection time of 310 ± 45 min was significantly more potent than DEET (160 ± 17 min). It could thus be considered for future investigation against other mosquitoes.

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Phytochemical identification, acute and subchronic oral toxicity assessments of hydroalcoholic extract of Acroptilon repens in BALB/c mice: A toxicological and mechanistic study

Cited by 8 publications

References 47 publications

Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway

Solidagenone from Solidago chilensis Meyen Protects against Acute Peritonitis and Lipopolysaccharide-Induced Shock by Regulating NF-κB Signaling Pathway

Assessment of the Acute and Chronic Toxicity Studies of Ethanol Extract of Blumea balsamifera (L.) DC. Leaves on Murine Models

Repellent efficacy of the nanogel containing Acroptilon repens essential oil in comparison with DEET against Anopheles stephensi

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