Phytochemical investigation and antimicrobial activity of an endophytic fungus Phoma sp.

Hussain, Hidayat; John, Markus; Al‐Harrasi, Ahmed; Shah, Aamer Ali; Hassan, Zahid; Abbas, Ghulam; Rana, Usman Ali; Green, Ivan R.; Schulz, Barbara; Krohn, Karsten

doi:10.1016/j.jksus.2014.08.001

Cited by 28 publications

(6 citation statements)

References 7 publications

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“…The use of plants as a medicine is a practice adopted by traditional people; however, large-scale production of medicines is difficult. Therefore, the use of microorganisms that live inside the plant (endophytic) can be an alternative for the production of biologically active compounds through biotechnological techniques ( Jiang et al, 2013 ; Hussain et al, 2015 ; Rajamani et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Potential of Streptomyces ansochromogenes (PB3) Isolated From a Plant Native to the Amazon Against Pseudomonas aeruginosa

et al. 2020

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The objective of this study was to evaluate the antibacterial action of filamentous bacteria isolated from the Byrsonima crassifolia leaf. An endophytic bacterium has been identified by classical and molecular techniques as Streptomyces ansochromogene . Screening for antibacterial action against pathogens with medical relevance ( Klebsiella pneumoniae ATCC 700603, Pseudomonas aeruginosa ATCC 15692, Staphylococcus aureus ATCC 6538, Corynebacterium diphtheriae ATCC 27012, Mycobacterium abscessus , Cryptococcus gattii ATCC 24065, and Cryptococcus neoformans ATCC 24067) demonstrated activity against the bacterium P. aeruginosa ATCC 0030 with inhibition diameter zones (IDZ) of 17.6 ± 0.25 mm in the preliminary screening in solid medium. After fermentation in liquid medium, an IDZ of 19.6 ± 0.46 mm and a minimum inhibitory concentration (MIC) of 0.5 mg/mL were detected. The antibiofilm action was observed with 100% inhibition of biofilm formation at a concentration of 0.250 mg/mL. When the infection curve was prepared, it was observed that the metabolite was effective in protecting the larvae of Tenebrio molitor . The metabolite does not show toxicity for eukaryotic cells. The leishmanicidal activity demonstrated that the metabolite presented a dose-dependent effect on the promastigotes forms of Leishmania amazonensis growth and the estimated IC 50 /72 h was 71.65 ± 7.4 μg/mL. Therefore, it can be concluded that the metabolite produced by the endophytic bacterium Streptomyces sp. is promising for future use as an alternative strategy against bacterial resistance.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Potential of Streptomyces ansochromogenes (PB3) Isolated From a Plant Native to the Amazon Against Pseudomonas aeruginosa

et al. 2020

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“…10.16) from the fungus Phoma spp., and these metabolites illustrated good antimicrobial effects (Hussain et al 2014). The same authors have also reported sclerodin (172), 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-( 2 Metabolite 172 illustrated moderate antialgal effects, while compounds 173-175 possess moderate antifungal properties (Hussain et al 2015). In another investigation, the benzodioxin (176) and methoxyphenoxyacrylic acid (177) were isolated from the fungus Phoma macrostoma (Nalli et al 2019), and botryosphaeridione (178) was obtained from Phoma sp.…”

Section: Nonaromatic Polyketidesmentioning

confidence: 86%

Fruitful Decade of Phoma Secondary Metabolites from 2011 to 2020: Chemistry, Chemical Diversity, and Biological Activities

Hussain

Elizbit

Ali

et al. 2021

Phoma: Diversity, Taxonomy, Bioactivities, and Nanotechnology

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“…There are several reports which provide conclusive evidence that endophytic Phoma species living in plants secrete potential antimicrobial compounds (Fig. 2 ) (Hussain et al 2015 ; Huang et al 2017 ; da Silva et al 2017 ; de Vries et al 2018 ; Nalli et al 2019 ; El-Zawawy et al 2020 ; Li et al 2020 ; Rai et al 2020 ; Hu et al 2021 ). For example, the compounds like α-tetralone derivative (3S)-3,6,7-trihydroxy-α-tetralone, together with cercosporamide, β-sitosterol, and trichodermin reported from the ethyl acetate extract of endophytic Phoma sp.…”

Section: Phoma: the Producer Of Novel Bioactive Metabolitesmentioning

confidence: 98%

“…(I) Sclerodin, (II) 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4H-phenaleno[1,2-b]furan-4,6(5H)-dione, (III) Atrovenetinone, and (IV) Sclerodione. Reprinted from Hussain et al ( 2015 ) under Creative Common Rights Licence …”

Section: Phoma: the Producer Of Novel Bioactive Metabolitesmentioning

confidence: 99%

Promising antimicrobials from Phoma spp.: progress and prospects

et al. 2022

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The increasing multidrug-resistance in pathogenic microbes and the emergence of new microbial pathogens like coronaviruses have necessitated the discovery of new antimicrobials to treat these pathogens. The use of antibiotics began after the discovery of penicillin by Alexander Fleming from Penicillium chrysogenum. This has attracted the scientific community to delve deep into the antimicrobial capabilities of various fungi in general and Phoma spp. in particular. Phoma spp. such as Phoma arachidicola, P. sorghina, P. exigua var. exigua, P. herbarum, P. multirostrata, P. betae, P. fimeti, P. tropica, among others are known to produce different bioactive metabolites including polyketides, macrosporin, terpenes and terpenoids, thiodiketopiperazines, cytochalasin derivatives, phenolic compounds, and alkaloids. These bioactive metabolites have already demonstrated their antimicrobial potential (antibacterial, antifungal, and antiviral) against various pathogens. In the present review, we have discussed the antimicrobial potential of secondary metabolites produced by different Phoma species. We have also deliberated the biogenic synthesis of eco-friendly antimicrobial silver nanoparticles from Phoma and their role as potential antimicrobial agents.

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Phytochemical investigation and antimicrobial activity of an endophytic fungus Phoma sp.

Cited by 28 publications

References 7 publications

Antimicrobial Potential of Streptomyces ansochromogenes (PB3) Isolated From a Plant Native to the Amazon Against Pseudomonas aeruginosa

Antimicrobial Potential of Streptomyces ansochromogenes (PB3) Isolated From a Plant Native to the Amazon Against Pseudomonas aeruginosa

Fruitful Decade of Phoma Secondary Metabolites from 2011 to 2020: Chemistry, Chemical Diversity, and Biological Activities

Promising antimicrobials from Phoma spp.: progress and prospects

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