Phytochemical investigation and antioxidant activity ofDuranta repens

Shahat, Abdelaaty A.; Nazif, Naglaa M.; Abou-Setta, Lobna M; Ibrahim, Noha; Cos, Paul; Miert, Sabine Van; Pieters, Luc; Vlietinck, A. J.

doi:10.1002/ptr.1766

Cited by 31 publications

(17 citation statements)

References 11 publications

(11 reference statements)

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“…The total phenolic contents of Z. spina-christi were measured by the Folin-Ciocalteu assay of Singleton et al [16] and Shahat et al [13] and reported as mgGallic Acid equivalents (GAE) per g of sample. As shown in Figure 2, the total extract, ZSC-1, had the highest phenolic content (82.3 mg/g), followed by ZSC-2, ZSC-3, and ZSC-4 at 76.3, 73.6, and 68.3 mg/g respectively.…”

Section: Total Polyphenolic Contentmentioning

confidence: 99%

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

Al-Ghamdi¹,

Shahat²

2018

Trop. J. Pharm Res

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Purpose: To investigate the antioxidant, hypoglycemic and antidiabetic activities as well as the phenolic composition of Ziziphus spina-christi (ZSC) Methods: Eighty percent methanol extract (ZSC-1), as well as ethyl acetate (ZSC-2), n-butanol (ZSC-3) and aqueous (ZSC-4) fractions were administered orally to mice at doses of 250 and 500 mg/kg of body weight. The hypoglycemic and anti-diabetic activities of these fractions in the treated

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Section: Total Polyphenolic Contentmentioning

confidence: 99%

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

Al-Ghamdi¹,

Shahat²

2018

Trop. J. Pharm Res

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“…The methanol extract and compounds 1 , 2 and 7 were cytotoxic for HepG2 cells and 7 was the most cytotoxic agent (IC 50 = 1.68, 1.07, 0.94 and 0.60, respectively, Figure 4 ). Although different extracts of D. repens have been investigated as antioxidant and antiviral [ 9 , 10 ], to our knowledge, this work is the first trial to investigate the cytotoxicity of the methanol extract of D. repens leaves against HepG2 solid tumor cell lines. The strong anti-cancer activity of D. repens leaf methanol extract may be attributed to the corresponding activities of the extract constituents.…”

Section: Resultsmentioning

confidence: 99%

“…Thrombin inhibitory coumarins were isolated from fruits [ 8 ]. The ethyl acetate soluble fraction of D. repens methanol extract showed antioxidant and antiviral activities [ 9 , 10 ]. Triterpenes [ 3 ], flavonoids, steroids, C -alkylated flavonoids [ 11 , 8 ], acetosides [ 10 ] and some alkaloids [ 12 ] were isolated from D. repens (var.…”

Section: Introductionmentioning

confidence: 99%

New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity

et al. 2009

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From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2) were isolated. In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, 1H-, 13C-NMR, 1H-1H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.

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“…cernua [7]. The ethyl acetate fraction of the methanol extract of the whole plant of D. repens showed radical scavenging activity in the 1,1-diphenyl-2-picrylhydrazyl assay [12], antiviral [13], insecticide properties against Aedes aegypti and Attagenus piceus [14], enzyme-inhibitory activity against thrombin [15], and α-glucosidase Inhibitory [16].…”

Section: Introductionmentioning

confidence: 99%

The Phytochemical Screening Hexane and Methanol Extract of Sinyo Nakal (Duranta Repens)

Sugita

Amilia

Budi

et al. 2020

Asian J Pharm Clin Res

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Objective: Phytochemicals are naturally present in every part of plants range from leaves, stem bark, and fruits to roots. The use of plant-based medicine is popular among individuals and communities in developing countries. This study evaluated that the phytochemical profile of Duranta repens fruits was collected from Jombang, East Java, Indonesia. Methods: Air-dried D. repens fruits were macerated by n-hexane and methanol, a separate flask. n-Hexane extract, then underwent saponification to remove fat. Then, the unsaponifiable of n-hexane and methanol extract was tested through phytochemical screening, respectively. Results: The methanol extract showed the presence of alkaloids, flavonoids, tannins, and steroids, but the unsaponifiable fraction only contained steroids. The unsaponifiable fraction was found to be a mixture of hydrocarbons ranging from C13-C20, fatty acids (palmitic and linoleic acid), squalene, and Vitamin E. Conclusion: The phytochemical screening of the plant plays an important role for pharmaceutical studies especially discovering new potential drugs for the treatment of various diseases.

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Phytochemical investigation and antioxidant activity ofDuranta repens

Cited by 31 publications

References 11 publications

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

New Triterpene Saponins from Duranta repens Linn. and Their Cytotoxic Activity

The Phytochemical Screening Hexane and Methanol Extract of Sinyo Nakal (Duranta Repens)

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