Phytochemical Investigation of Virola peruviana, A New Hallucinogenic Plant

Lai, Alice; Tin‐Wa, M.; Mika, Edward S.; Persinos, Georgia J.; Farnsworth, Norman R.

doi:10.1002/jps.2600620945

Cited by 16 publications

(3 citation statements)

References 11 publications

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“…[3] Specifically, V. elongata grows in Panama to Brazil; V. sebifera, from Honduras to Brazil; both of them are very common in South America [3]. On the other hand, the species V. pavonis and V. peruviana are located in the Peruvian Amazon [12,13]. V. venosa is found in the Colombian Amazon region [14] and Brazil [15].…”

Section: Geographic Distributionmentioning

confidence: 99%

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Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity

et al. 2021

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Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk medicine for the treatment of several ailments, such as rheumatic pain, bronchial asthma, tumors in the joints, intestinal worms, halitosis, ulcers, and multiple infections, due to their pharmacological activity. This review presents an updated and comprehensive summary of Virola species, particularly their ethnomedicinal uses, phytochemistry, and biological activity, to support the safe medicinal use of plant extracts and provide guidance for future research. The Virola spp.’s ethnopharmacology, including in the treatment of stomach pain and gastric ulcers, as well as antimicrobial and tryponosomicidal activities, is attributable to the presence of a myriad of phytoconstituents, such as flavonoids, tannins, phenolic acids, lignans, arylalkanones, and sitosterol. Hence, such species yield potential leads or molecular scaffolds for the development of new pharmaceutical formulations, encouraging the elucidation of not-yet-understood action mechanisms and ascertaining their safety for humans.

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Section: Geographic Distributionmentioning

confidence: 99%

“…The isolation of 5-methoxy-N,N-dimethyltryptamine as well as the identification of N,N-dimethyltryptamine and 5-methoxytryptamine in V. peruviana has shown that the compounds may have hallucinogenic effects [12].…”

Section: Phytochemistrymentioning

confidence: 99%

Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity

et al. 2021

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“…Populações indígenas de regiões amazônicas fazem uso das cascas de várias espécies de Virola em preparações consumidas em rituais religiosos. O efeito alucinógeno atribuído a essas preparações é conseqüência da presença de alcalóides indólicos triptaminérgicos (Agurrel et al, 1969;Lai et al, 1973;Lopes et al, 1982). Foram identifi cados nas cascas da Virola sebifera alguns alcalóides como a N,N-dimetiltriptamina e derivados, além de -carbolinas (Corothie;Nakano, 1969;Hashimoto, 1987).…”

Section: Introductionunclassified

Atividade antiproliferativa dos extratos e da fração orgânica obtidos das folhas de Virola sebifera Aubl. (Myristicaceae)

Denny

Zacharias

Kohn

et al. 2007

Rev. bras. farmacogn.

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RESUMO:As cascas de Virola sebifera (Myristicaceae) são utilizadas por populações indígenas amazônicas em preparações alucinógenas, nas quais foram encontrados alcalóides como a dimetiltriptamina e seus derivados. Considerando a enorme importância dos alcalóides isolados de plantas na terapêutica do câncer e a presença desses compostos em espécies de Virola, o presente trabalho teve por objetivo o estudo da atividade antiproliferativa em cultura de células tumorais humanas de extratos e da fração orgânica, obtidos das folhas de Virola sebifera. O extrato bruto diclorometânico (EBD) foi considerado o mais ativo, com seletividade principalmente para a linhagem de pulmão (NCI-460) -IC 50 : 4,46 g/mL e para a fração orgânica (FO) obtida por extração ácido-base -IC 50 ; 6,91 g/mL. A atividade observada possivelmente pode ser atribuída a alcalóides ou compostos nitrogenados que foram evidenciados pelo corante Dragendorff. Assim, a purifi cação da FO será necessária a fi m de comprovar a presença de compostos nitrogenados, através de isolamento e determinação estrutural, bem como a participação desses compostos na atividade antiproliferativa observada.Unitermos: Virola sebifera, Myristicaceae, atividade antiproliferativa, células tumorais, alcalóides.ABSTRACT: "Antiproliferative activity of extracts and fractions from Virola sebifera Aubl. leaves (Myristicaceae)". Barks of Virola sebifera (Myristicaceae) used by Amazonian Indian communities in hallucinogenic snuff preparations have yielded dimethyltryptamine and derivatives. Considering the importance of the alkaloids isolated from plants for the development of chemotherapy, and the presence of these compounds in several Virola species, the scope of this work was to evaluate the antiproliferative activity of the extracts and the organic fraction from Virola sebifera leaves. The crude dichloromethane extract was the most active with selectivity for lung line (NCI-460) -IC 50 : 4.46 g/mL, as well as the organic fraction (OF) -IC 50 : 6.91 g/mL. The observed activity could probably be attributed to alkaloids or nitrogen compounds that were evidenced by the Dragendorff reagent. However, the future purifi cation of OF will be necessary to prove the presence of alkaloids and their role in the antiproliferative activity in human cells as well as isolating and identifying these compounds.

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Psilocin analogs. III. Synthesis of 5‐methoxy‐ and 5‐hydroxy‐1,2,3,4‐tetrahydro‐9H‐pyrido[3,4‐b]indoles

Repke¹,

Ferguson²

1982

Journal of Heterocyclic Chem

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Phytochemical Investigation of Virola peruviana, A New Hallucinogenic Plant

Cited by 16 publications

References 11 publications

Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity

Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity

Atividade antiproliferativa dos extratos e da fração orgânica obtidos das folhas de Virola sebifera Aubl. (Myristicaceae)

Psilocin analogs. III. Synthesis of 5‐methoxy‐ and 5‐hydroxy‐1,2,3,4‐tetrahydro‐9H‐pyrido[3,4‐b]indoles

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