Phytochemical investigation on the fruits of Camptotheca acuminata and their chemotaxonomic significance

Molecularly imprinted polymers based on carboxymethylcellulose/graphene oxide composites (CMC/GO@MIPs) were prepared using surface molecular imprinting technology for the adsorption of hydroxycamptothecin (HCPT). Using molecular simulations, methacrylic acid was selected as a suitable monomer via a preliminary green scheme. The structure and adsorption properties of CMC/GO@MIPs were investigated through various characterization methods and adsorption experiments. The adsorption mechanism was examined using an adsorption model. The Langmuir isotherm model and pseudo-second-order kinetic model matched well with the adsorption results, with a maximum adsorption capacity of 62.92 mg/g. Adsorption equilibrium was achieved within 30 min. Further, CMC/GO@MIPs exhibited excellent selectivity for HCPT (imprinting factor of 2.60) and good recyclability; the adsorption capacity decreased by only 10.50% after seven adsorption–desorption cycles. The purity of HCPT was 50.94% after separation in the actual sample. CMC/GO@MIPs prepared in this study are simple and convenient to use and display high specificity, extraction efficiency, stability, and reusability for the separation and enrichment of HCPT. This study provides a method for the separation and purification of HCPT in Camptotheca acuminata Decne and is an important reference for the separation, enrichment, and purification of natural components present in complex plant matrices.

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Molecularly Imprinted Polymer Based on Carboxymethylcellulose/Graphene Oxide Composites for Selective Adsorption of Hydroxycamptothecin

Nie

Ahmad

et al. 2022

ACS Appl. Polym. Mater.

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Plant Pyranocoumarins: Description, Biosynthesis, Application

Ханды

Sofronova

Gorpenchenko

et al. 2022

Plants

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This overview article contains information about pyranocoumarins over the last 55 years. The article is based on the authors’ phytochemical and physiological studies in vivo and in vitro as well as search and analysis of data in literature available on Google Scholar, Web of Science, PubMed, and ScienceDirect before January 2022. Pyranocoumarins are synthesized in plants of the Apiaceae, Rutaceae families, and one species in each of the Cornaceae, Calophyllaceae, and Fabaceae families can synthesize this class of compounds. The physiological role of these compounds in plants is not clear. It has been proven that these substances have a wide range of biological activities: anti-cancer, anti-spasmatic, and anticoagulant, and they also inhibit erythrocyte lysis and accumulation of triacylglycerides. The overview generalizes the modern understanding of the classification, structure, and biological activity of natural pyranocoumarins, and summarizes dispersed data into a unified scheme of biosynthesis. The review analyzes data on the localization and productivity of these substances in individual organs and the whole plant. It discusses a link between the unique structure of these substances and their biological activity, as well as new opportunities for pyranocoumarins in pharmacology. The article evaluates the potential of different plant species as producers of pyranocoumarins and considers the possibilities of cell cultures to obtain the end product.

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Phytochemical investigation on the fruits of Camptotheca acuminata and their chemotaxonomic significance

Cited by 2 publications

References 90 publications

Molecularly Imprinted Polymer Based on Carboxymethylcellulose/Graphene Oxide Composites for Selective Adsorption of Hydroxycamptothecin

Molecularly Imprinted Polymer Based on Carboxymethylcellulose/Graphene Oxide Composites for Selective Adsorption of Hydroxycamptothecin

Plant Pyranocoumarins: Description, Biosynthesis, Application

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