Phytochemical investigations and bioactivity evaluation of liverworts as a function of anti-inflammatory and antinociceptive properties in animal models

Tosun, Alev; Akkol, Esra Küpeli; Süntar, İpek; Kiremit, Hatice Özenoğlu; Asakawa, Yoshinori

doi:10.3109/13880209.2013.774028

Cited by 18 publications

(21 citation statements)

References 22 publications

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“…Corsifuran A (9) is isolated from the Mediterranean liverwort Corsinia coriandrina, and exhibits promising antinociceptive effect in mice (Scheme 4 B). [13] OKR of rac-9 proceeded, and remaining (S)-9 was isolated in 45 % yield with 91 % ee (K rel = 21.2).…”

Section: Angewandte Chemiementioning

confidence: 99%

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

Sun

Liu

et al. 2020

Angew Chem Int Ed

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A manganese-catalyzed oxidative kinetic resolution of cyclic benzylic ethers through asymmetric C(sp 3) À H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the a position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.

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Section: Angewandte Chemiementioning

confidence: 99%

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

Sun

Liu

et al. 2020

Angew Chem Int Ed

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“…Corsifuran A ( 9 ) is isolated from the Mediterranean liverwort Corsinia coriandrina , and exhibits promising antinociceptive effect in mice (Scheme 4 B). [13] OKR of rac‐ 9 proceeded, and remaining ( S )‐ 9 was isolated in 45 % yield with 91 % ee ( K rel =21.2) [12c] . A gram‐scale reaction proceeded without obvious loss of selectivity factor, as demonstrated by recovery of ( R )‐ 5 j in 47 % yield with 97 % ee (Scheme 4 C).…”

Section: Entry Catalyst Conv [%][B] Ee [%][C] Krelmentioning

confidence: 99%

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

Sun

Liu

et al. 2020

Angewandte Chemie

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“…80 Some non-local species have been studied for their antioxidant 81 and anti-inflammatory activities. 82 The case of Colchicacea family is one of the strangest and most interesting. Israel and Palestine is home to 12 very beautiful plant species of this family, but none of them was studied for anti-inflammatory or antioxidant activity.…”

Section: Plant Materials Preparation Extractionmentioning

confidence: 99%

“…As for nonlocal plants, Riccia fluitans and some others, have been extensively studied. 106,107 Contrary to the ordinary look of Marchantiophyta, the flowers of the Orchidaceae family are among the most spectacular in nature. Yet, the local plants of this family (31) have been totally ignored in terms of antioxidant and anti-inflammatory research, so far.…”

Section: Plant Materials Preparation Extractionmentioning

confidence: 99%

Antioxidant and Anti-inflammatory Activities of Plants Extracts of Israel and Palestine. Unexplored Paradise

Azab

2019

ECB

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Antioxidant and anti-inflammatory activities are among the most important properties of plant materials used by humans. For many medicinal plants and other natural products sources, there is clear relationship between these properties. Despite the fact that some approved, commercial drugs were developed from natural products that possess these properties, published literature scan reveals a disappointing image, in some geographical regions, with rich flora, the vast majority of these plants were never studied for antioxidant and/or anti-inflammatory activities. Expectedly, some plant families were extensively studied, while others, with some of the most common and widespread plant species, were almost totally ignored. In this review, we will introduce the current situation of studying medicinal properties of plants, especially antioxidant and anti-inflammatory activities, on the central part of the Eastern region of the Mediterranean basin. We will also present an overall view of future research opportunities and scientific collaborations. These opportunities and collaborations must be based on systematic mapping of current knowledge.

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Phytochemical investigations and bioactivity evaluation of liverworts as a function of anti-inflammatory and antinociceptive properties in animal models

Abstract: The present study confirms the claimed anti-inflammatory activity of liverworts in a scientific platform.

Cited by 18 publications

References 22 publications

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

Oxidative Kinetic Resolution of Cyclic Benzylic Ethers

Antioxidant and Anti-inflammatory Activities of Plants Extracts of Israel and Palestine. Unexplored Paradise

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