Phytochemical, Pharmacological and Biological Profiles of Tragia Species (Family: Euphorbiaceae)

Reddy, Bonam Srinivasa; Rao, N. Rama; Vijeepallam, Kamini; Pandy, Vijayapandi

doi:10.21010/ajtcam.v14i3.11

Cited by 29 publications

(18 citation statements)

References 22 publications

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“…These results could allot to the presence of phenolic compounds, which play an efficient role as a hydrogen donator, reducing agents, and singlet oxygen quenchers [ 20 , 21 ]. Many plants from the family Euphorbiaceae were used in traditional, complementary, and alternative medicine [ 22 ]. Melo et al (2011) analyzed other species Euphorbiaceae , such as Croton blanchetianus Baill and Jatropha mollissima (Pohl) Baill, finding an IC50 of 94.0 and 55.0 μg/mL, respectively [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Cường

Thinh

et al. 2021

Molecules

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Euphorbia tirucalli is a medicine plant possessing many bioactive properties. This paper focused on phytochemical screening (alkaloid, flavonoid, saponin, tannin, and anthraquinone), quantification of polyphenol and flavonoids, and activating evaluation of antioxidants and antimicrobial properties against Xanthomonas axonopodis of different extracts from Euphorbia tirucalli grown in Binh Thuan, Vietnam. The best activity fraction was used for purification and determining bioactive ingredients. The results showed that the phytochemical study revealed the presence of alkaloids, flavonoids, tannins, and terpenoids in the ethyl acetate fraction. Saponin and anthraquinone did not present in all extracts. The content of polyphenol and flavonoid of Euphorbia tirucalli stem was in the range of 16.65–106.32 mg EqAG/g and 97.97–450.83 μg QE/g. The ethyl acetate fraction showed higher amounts of polyphenol and flavonoids and antimicrobial activity against X. axonopodis than other fractions. The antioxidant (SC50) activity of Euphorbia tirucalli stem was in the range of 12.91 ± 0.70 and 528.33 ± 25.15 μg/mL. At concentrations of 5.0 and 7.5 mg/mL, the diameter of inhibition of the ethyl acetate fraction was 14.33 ± 0.76 mm and 17.87 ± 0.57 mm, respectively. The MIC (minimum inhibitory concentration) was 0.156 mg/mL. Scopoletin, gallic acid, and piperic acid got MICs corresponding to 78, 312, and 312 μg/mL, respectively. Scopoletin, gallic acid, and piperic acid were found in the ethyl acetate fraction of Euphorbia tirucalli and exhibited the treatment of citrus bacteria canker and plant diseases.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Cường

Thinh

et al. 2021

Molecules

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“…We have created a library of 586 bioactive phytochemicals having antiviral properties from 47 medicinal plants from the literature ( Supplementary Table 1 ). 21 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 The 3D.sdf structures of all the selected phytochemicals were obtained from the PubChem database ( https://pubchem.ncbi.nlm.nih.gov/ ).…”

Section: Methodsmentioning

confidence: 99%

The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins

Singh

Chauhan

Pandit

et al. 2022

Journal of Traditional and Complementary Medicine

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Background The severe acute respiratory syndrome-2019 has affected more than 190 million people around the world and caused severe crises throughout the globe. Due to rapid mutation in the viral genome, it became important to simultaneously improvise the host immunity while targeting the viral protein to reduce the severity of the infection. Aim The current computational work focuses on multi-level rigorous screening of 47 medicinal plant-based phytochemicals for discovering effective phytochemical inhibitors against the host and viral targets. Experimental procedure A total of 586 phytochemicals were analyzed in detail based on their drug-likeness, pharmacological properties, and structure-based activity against the viral proteins (Spike glycoprotein, Papain-like protease, and Main protease) and host proteins (ACE2, Importin-subunit α-5, and β-1). Phytochemicals showing higher binding affinity with the dual capacity to target both the categories of proteins were further analyzed by profiling their chemical reactivity using Density-functional theory (DFT) based quantum chemical methods. Finally, detailed molecular dynamics simulations were performed to analyze the interactions of the complexes. Results and conclusion The results revealed that the selected phytochemicals from Andrographis paniculata , Aconitum heterophyllum , Costus speciosus and Inula racemosa may have the capacity to act with prominent affinity towards the host and viral proteins. Therefore, The Combination of active phytochemicals of these plants may prove to be more beneficial and can be used for developing the potential phytotherapeutic intervention.

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“…The detailed phytochemical and pharmacological properties of these species were reviewed and reported elsewhere. 12 Briefly, the different solvent extracts of different parts of Tragia plukenetii (TP) have been reported for antiulcer, 13 antioxidant and antitumor, 14 wound healing, antimicrobial, [15][16][17] antipyretic, diuretic, antiasthmatic, antispasmodic, 18 antidiabetic, treatment in polio, male impotency and elephantiasis, 19 treatment of uterine complaints and skin irritation, 20 antinociceptive 21 and treatment of gastroenteritis, stomach ache, gonorrhea and tapeworm infestation. 22,23 The above-mentioned virtues are due to the presence of valuable phytochemicals such as sterols, alkaloids, flavonoids, glycosides, saponins and tannins.…”

Section: Phytochemical In Vitro Antioxidant and In Vivo Safety Evalumentioning

confidence: 99%

Phytochemical, in vitro Antioxidant and in vivo Safety Evaluation of Leaf Extracts of Tragia plukenetii

Bonam¹,

Manoharan²,

Pandy³

et al. 2019

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Objective: To investigate the phytochemical properties, in vitro antioxidant and in vivo safety profile of leaf extracts of Tragia plukenetii (TP). Methods: TP leaves were obtained from the south part of India (Guntur District, Andhra Pradesh) and it was extracted with different solvents (Benzene Extract (BE), Chloroform Extract (CE) and methanolic extract (ME)). These TP extracts were analyzed for the in vitro antioxidant activity by DPPH reducing power, β-carotene-linoleic acid complex and iron chelation assays followed by in vivo acute oral and dermal toxicities using Swiss mice and Wistar rats respectively. Results: The present study results revealed ME exhibited an effective and powerful antioxidant activity when compared to a standard antioxidant, Butylated hydroxytoluene (BHT). ME was found to be effective in DPPH, β-carotene-linoleic acid complex and iron chelation assays respectively. In vivo acute oral toxicity study revealed that mice treated with up to 5000 mg/kg of BE, CE and ME did not show any signs of toxicity. Furthermore, similarly, acute dermal toxicity study demonstrated that BE, CE and ME did not exhibit any signs of dermal toxicity up to 1000 mg/kg in rats. Conclusion: TP extracts possess an excellent antioxidant activity with a devoid of any signs of acute oral and dermal toxicities.

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Phytochemical, Pharmacological and Biological Profiles of Tragia Species (Family: Euphorbiaceae)

Cited by 29 publications

References 22 publications

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

Phytochemical Screening and Evaluation of Antioxidant Properties and Antimicrobial Activity against Xanthomonas axonopodis of Euphorbia tirucalli Extracts in Binh Thuan Province, Vietnam

The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins

Phytochemical, in vitro Antioxidant and in vivo Safety Evaluation of Leaf Extracts of Tragia plukenetii

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