Phytochemical, pharmacological and tissue culture applications of Wedelia spp. – A review

Abstract

Abstract. Wedelia spp. belonging to the family asteraceae whereby most of the species such as W. chinensis (Osbeck) Merr., W. paludosa (Blume), W. trilobata (L.) Hitchc, W. calendulacea (L.) Less., W. prostrata Dalzell & A. Gibson etc. had been traditionally used by the ancient people for medicinal purposes. Due to that, extensive studies regarding the phytochemical and pharmacological aspects of this genus have been carried out for six decades. Most of the studies indicated that the plants from this genus have potential as medicinal herbs to treat diseases such as cancer, diabetes, heart and liver failure, etc. In this paper the phytochemical and pharmacological aspects of some plants of Wedelia genus are reviewed. Tissue culture applications of this genus are not extensively studied, thus in the present review some in vitro results from these investigations are also presented.

Anticancer Activity of N-Hexane Extract from Sphagneticola trilobata (L.) J.F Pruski Against MCF-7 Breast Cancer Cell

“…The higher concentration of n-hexane extract from S.trilobata toward MCF-7 cells would produce a greater mortality percentage of MCF-7. This might be influenced by the presence of secondary metabolites in S. trilobata extract as explained by Ahmed et al (2019) that Wedelia trilobata (L.) Hitchc, consisting of. 3α-tigloyloxypterokaurene L3, ent-17-hydroxy-kaura-9 (11), 15-dien-19-oic acid, wedelobatins A and wedelobatins B which have toxic effects on cancer cells.…”

Antioxidant and cytotoxic activities of the ethyl acetate extract of Sphagneticola trilobata (L.) J.F. Pruski on MCF-7 breast cancer cell

“…[ 29 ] and Ahmed et al . [ 11 ] that reported S. trilobata (the previous name is W. trilobata ) consists of 3α-tigloyloxypterokaurene L3, wedelobatins A and wedelobatins B, sesquiterpene lactones, trilobed-6-O-isobutyrate, kaurenoic acid, eudesmanolidelactones, and luteolin.…”

“…[ 7 ] It is known as “ Wedelia ” in the Pacific, Singapore daisy in Australia,[ 8 ] creeping daisy in English,[ 9 ] Seruni/Sernai in Indonesia, and Wedelia kuning in Malaysia. [ 10 ] For six decades ago, some species of this family ( Wedelia chinensis , Wedelia paludosa , Wedelia calendulaceae , Wedelia prostrata , Wedelia spp., and Wedelia trilobata ) have been great interest in the pharmaceutical therapy[ 11 ] since they exhibited biological activities including antibacterial, antifungal, anti-plasmodium, antidiabetic, hepatoprotective, antipyretic–analgesic, and anticancer activities. [ 4 8 12 13 14 15 ] Nevertheless, the available current literature has not documented yet about the evaluation of antioxidant and cytotoxic properties of the ethyl acetate extract from S. trilobata leaves against MCF-7 cell line, especially the sample from Aceh-Indonesia.…”

Biogenic synthesis of silver nanoparticle from flower extract of Wedelia chinensis and their antibacterial and antioxidant activity

“…As activities of plant mediated nanoparticles differ with plant materials, so there is need to extend phytonanotechnology to more plant materials for their wider applications. Plants of genus Wedelia of Asteraceae are being used in traditional medicines and they have shown significant antidiabetic, anticancer, hepato-protective and other activities (Nomani et al 2013, Ahmed et al 2019. Wedelia chinensis commonly known as pilabringraj is a medicinal herb distributed in different parts of India, Japan and China.…”