Phytochemical Profile and Qualification of Biological Activity of an Isolated Fraction of Bellis perennis

Marques, Thiago Henrique Costa; Melo, Cássio Herbert Santos de; Carvalho, Rusbene Bruno Fonseca de; Costa, Luciana Muratori; Souza, Alexandre Araújo de; David, Jorge M.; David, Juceni P.; Freitas, Rivelilson Mendes de

doi:10.4067/s0716-97602013000300002

Cited by 21 publications

(14 citation statements)

References 39 publications

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“…Terpenes have been shown to exhibit antioxidant activity in three main ways: through singlet oxygen quenching, through hydrogen transfer, and through electron transfer [48]. The B-ring in flavonoids, which is rich in hydroxyl groups, reacts with superoxide [49]. Some studies have shown that some terpenes regulate the glutamate decarboxylase expression and aspartic and glutamic acid levels in the brain [50] and that the GABA agonist capacity of some flavonoids is related to hydroxyl positions [51].…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Carmona-Aparicio¹,

Cárdenas-Rodríguez²,

Delgado³

et al. 2019

Oxidative Medicine and Cellular Longevity

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Kainic acid (KA) has been used to study the neurotoxicity induced after status epilepticus (SE) due to activation of excitatory amino acids with neuronal damage. Medicinal plants can protect against damage caused by KA-induced SE; in particular, organic extracts of Heterotheca inuloides and its metabolite quercetin display antioxidant activity and act as hepatoprotective agents. However, it is unknown whether these properties can protect against the hyperexcitability underlying the damage caused by KA-induced SE. Our aim was to study the protective effects (with regard to behavior and antioxidant activity) of administration of natural products methanolic (ME) and acetonic (AE) extracts and quercetin (Q) from H. inuloides at doses of 30 mg/kg (ME30, AE30, and Q30 groups), 100 mg/kg (ME100, AE100, and Q100 groups), and 300 mg/kg (ME300, AE300, and Q300 groups) against damage in brain regions of male Wistar rats treated with KA. We found dose-dependent effects on behavioral and biochemical studies in the all-natural product groups vs. the control group, with decreases in seizure severity (Racine’s scale) and increases in seizure latency (p<0.05 in the ME100, AE100, Q100, and Q300 groups and p<0.01 in the AE300 and ME300 groups); on lipid peroxidation and carbonylated proteins in all brain tissues (p<0.0001); and on GPx, GR, CAT, and SOD activities with all the treatments vs. KA (p≤0.001). In addition, there were strong negative correlations between carbonyl levels and latency in the group treated with KA and in the group treated with methanolic extract in the presence of KA (r=‐0.9919, p=0.0084). This evidence suggests that organic extracts and quercetin from H. inuloides exert anticonvulsant effects via direct scavenging of reactive oxygen species (ROS) and modulation of antioxidant enzyme activity.

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Section: Discussionmentioning

confidence: 99%

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Carmona-Aparicio¹,

Cárdenas-Rodríguez²,

Delgado³

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Nitric oxide reacts with various biological molecules and induces oxidizing product, neuronal toxicity, and epileptic attacks [ 22 ]. Substances with NO-scavenging action compete with oxygen, leading to reduced production of nitrite, showing the antioxidant activity [ 14 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

“…The flavonoids and isoflavonoids are probably electron donors. They have B-ring conjugated chemical structures rich in hydroxyl groups, which have potential antioxidant actions by reacting with and inactivating superoxide anions, oxygen lipid peroxide radicals, and/or stabilizing free radicals involved in the oxidative process by hydrogenation or complexing with oxidant species [ 14 ].…”

Section: Flavonoids With Action In the Cnsmentioning

confidence: 99%

“…Experimental evidences have clearly demonstrated that flavonoids exert antiepileptic activity by modulating the GABA A -Cl-channel complex, as they are structurally similar to benzodiazepines [ 13 ]. Thus, flavonoids may have a modulating role in the treatment of neurodegenerative diseases due to their phenolic nature, since they can disrupt cellular oxidative processes in the central nervous system [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Flavonoids on Oxidative Stress in Epilepsy

Diniz

Silva

Lima-Saraiva

et al. 2015

Oxidative Medicine and Cellular Longevity

133

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Backgrounds. Oxidative stress can result from excessive free-radical production and it is likely implicated as a possible mechanism involved in the initiation and progression of epileptogenesis. Flavonoids can protect the brain from oxidative stress. In the central nervous system (CNS) several flavonoids bind to the benzodiazepine site on the GABAA-receptor resulting in anticonvulsive effects. Objective. This review provides an overview about the role of flavonoids in oxidative stress in epilepsy. The mechanism of action of flavonoids and its relation to the chemical structure is also discussed. Results/Conclusions. There is evidence that suggests that flavonoids have potential for neuroprotection in epilepsy.

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“…[70] Experimental studies have shown that, due to their structural similarity with benzodiazepines, flavonoids exhibit antiepileptic effects by modulating the GABA A -Cl-channel complex. [71,72] Overall, avoiding unhealthy diets and adhering to the consumption of flavonoidrich foods can help people have a healthier body. PCs are beneficial nutrients that protect human health by fighting against the free radicals produced in the body cells and preventing oxidative damage.…”

Section: Which Compounds Received More Attention?mentioning

confidence: 99%

Polyphenols and their benefits: A review

Rasouli

Farzaei

Khodarahmi

2017

International Journal of Food Properties

307

259

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Let food be thy medicine and medicine be thy food" was expressed by Hippocrates more than 2000 years ago and the health benefits of natural food products have been considered for different goals since the ancient times. As natural phytochemicals, phenolic compounds (PCs) are a major class of semi-water-soluble compounds (from fruit and vegetable sources) with one or more benzene rings that are generally found in nature as glycosides. According to a review of the literature, food scientists have studied the many health benefits of these compounds against pernicious human diseases (HDs). Today, choosing a healthy diet has become an essential part of healthy living and fitness. Many studies have shown that people who follow a specific diet (especially polyphenol-rich diets) are at a low risk for a range of chronic diseases, such as obesity, diabetes, cancer, heart disease, etc. The present research is a comprehensive review of studies on PCs with a focus on HDs that seeks to find out why some PCs have received such considerable attention all over the world. Data were collected from the Scopus database and a hierarchical cluster analysis was used with Ward's method to analyze the data. The results showed that three countries most involved in research on PCs are USA, China, and India, and also found that quercetin, catechin, and kaempferol are the three most studied PCs. Cardiovascular diseases, cancer, obesity, diabetes, and infectious diseases are the major treatment targets for PCs. The review of the literature showed that these compounds share a common molecular mode of action against HDs. The Journal of Agriculture and Food Chemistry, Food Chemistry, PLOS ONE, and Planta Medica are also the most popular journals for covering original research on PCs. However, this study seeks to facilitate future studies on PCs through its findings.

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Phytochemical Profile and Qualification of Biological Activity of an Isolated Fraction of Bellis perennis

Cited by 21 publications

References 39 publications

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts fromHeterotheca inuloideson Several Rat Tissues following Kainic Acid-InducedStatus Epilepticus

The Role of Flavonoids on Oxidative Stress in Epilepsy

Polyphenols and their benefits: A review

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