Phytochemical Profile, Antilipase, Hemoglobin Antiglycation, Antihyperglycemic, and Anti-Inflammatory Activities of Solanum elaeagnifolium Cav.

Abstract

In the present investigation, the phenolic compounds of Solanum elaeagnifolium were identified, and the plant’s anti-lipase and anti-glycation effects on hemoglobin were discovered through in vitro experiments, as well as its short-term antihyperglycemic and anti-inflammatory effects. The chemical compound composition was detected using HPLC-DAD, the anti-lipase activity was tested in vitro using 4-nitrophenyl butyrate as a substrate, and the antiglycation activity of the plant extracts was also tested in vitro using a haemoglobin model. The antihyperglycemic effect was determined by inhibiting pancreatic α-amylase and α-glycosidase activity and performing an in vivo glucose tolerance test on normal rats, and the anti-inflammatory activity was determined by inducing paw inflammation with carrageenan. In both the SEFR (fruit) and SEFE (leaf) extracts, chromatographic analysis revealed the presence of quercetin 3-O-β-D-glucoside, rutin, and quercetin. SEFR inhibited the pancreatic lipase enzyme more effectively, with an IC50 of 0.106 ± 0.00 mg/mL. S. elaeagnifolium extracts demonstrated significant antiglycation activity, with 3.990 ± 0.23 mg/mL of SEFE and 3.997 ± 0.14 mg/mL of SEFR. When compared to positive and negative controls, plant extracts had very significant anti-diabetic and anti-inflammatory effects. The findings in this study and previous research on this plant encourage us to investigate other pharmacological activities of this plant besides its duiretic, cictrisant, and anti-ulcer activity.

Unveiling the Antianemic Activity, Physicochemical Aspects, Antioxidant Properties, and Mineral Profile of Petroselinum crispum L

“…The analysis was done by gradient mode, and the flow was maintained to 0.8 mL/min for 26 min. Extracts (20 μL) were injected, and compounds were identified using a diode array detector on 280 and 360 nm interval . The compounds were characterized based on comparing chromatogram retention time and λ max with standards …”

“…It is a rich source of natural antioxidants. 13 Antioxidant, 14 antibiotic, 15 antifungal, 16 neuroprotective, 17 nephroprotective, 18 antidiabetic, 19 analgesic, 20 spasmolytic, 21 antiplatelet, 22 laxative, 21 diuretic, 23 and aphrodisiac 24 are just a few of the pharmacological effects linked to parsley. Despite the extensive utilization of parsley in traditional medicine, this study was the first attempt to assess the antianemic effects of P. crispum .…”