Phytochemical profile, in vivo anti-inflammatory and wound healing activities of the aqueous extract from aerial parts of Cistus ladanifer L

Adadi, Imad; Ayadi, Rachida El; Bentayeb, Amar; Aaziz, Hicham; Bouymajane, Aziz; Altemimi, Ammar B.; Cacciola, Francesco; Ibaoui, Hamid El

doi:10.1016/j.jpba.2022.114960

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Moreover, Adadietal. [ 71 ] reported that the aqueous extracts of Cistus ladanifer were incorporated into a neutral Vaseline cream at 10% and 5%. In this study, sexually mature male rats were used by the carrageenan-induced paw edema and burn wound models.…”

Section: In Vivo Studies On the Effect Of Natural Products On The Wou...mentioning

confidence: 99%

“…The oral administration of the aqueous extract showed anti-inflammatory properties at a concentration of 500 mg/kg, compared to the control drug. Furthermore, the cream with the extract had a healing effect on the burn wound of rats by significatively decreasing the circumference of the edema paw [ 71 ].…”

Section: In Vivo Studies On the Effect Of Natural Products On The Wou...mentioning

confidence: 99%

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Wound Healing Properties of Natural Products: Mechanisms of Action

et al. 2023

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A wound is the loss of the normal integrity, structure, and functions of the skin due to a physical, chemical, or mechanical agent. Wound repair consists of an orderly and complex process divided into four phases: coagulation, inflammation, proliferation, and remodeling. The potential of natural products in the treatment of wounds has been reported in numerous studies, emphasizing those with antioxidant, anti-inflammatory, and antimicrobial properties, e.g., alkaloids, saponins, terpenes, essential oils, and polyphenols from different plant sources, since these compounds can interact in the various stages of the wound healing process. This review addresses the most current in vitro and in vivo studies on the wound healing potential of natural products, as well as the main mechanisms involved in this activity. We observed sufficient evidence of the activity of these compounds in the treatment of wounds; however, we also found that there is no consensus on the effective concentrations in which the natural products exert this activity. For this reason, it is important to work on establishing optimal treatment doses, as well as an appropriate route of administration. In addition, more research should be carried out to discover the possible side effects and the behavior of natural products in clinical trials.

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Section: In Vivo Studies On the Effect Of Natural Products On The Wou...mentioning

confidence: 99%

Section: In Vivo Studies On the Effect Of Natural Products On The Wou...mentioning

confidence: 99%

Wound Healing Properties of Natural Products: Mechanisms of Action

et al. 2023

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“…Natural products have shown promising properties in the wound healing process through diferent mechanisms of action [4]. Extracts [5][6][7][8], essential oils [9,10], and secondary metabolites [11] isolated from medicinal plants were found to be efective.…”

Section: Introductionmentioning

confidence: 99%

Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties

Rastegari

Manayi

Akbarzadeh

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Objective. Cedrus deodara (Roxb. Ex Lamb.) G. Don possesses various biological activities, which have been documented in modern and traditional medicine. In this study, burn wound healing activity of the methanol extract of C. deodara wood was evaluated via a burn wound model in Wistar rats. Methods. The methanol extract of C. deodara was evaluated for the contents of phenolic compounds, flavonoids, and tannins. Also, its antioxidant activity was determined using the DPPH assay. Then, a topical ointment containing the methanol extract of C. deodara (10%) was used to evaluate the healing effects on a model of second-degree thermal burn in 4 groups of 7 rats within 21 days. In this respect, average wound surface area, wound closure, and various histological features were examined. Results. Our findings revealed that the wounds treated with the methanol extract of C. deodara showed higher wound contraction (33.6, 87.1, and 93.4% on days 7, 14, and 21, respectively) compared with the positive control (27.6, 80.7, and 88.3% on days 7, 14, and 21, respectively) and the negative control (20.1, 77.9, and 80.2% on days 7, 14, and 21, respectively). According to the results from epitheliogenesis score, the number of inflammatory cells, neovascularization, and collagen density, good burn wound healing activity of the methanol extract of C. deodarawas demonstrated. Conclusion. Using the methanol extract of C. deodara in an ointment formulation can be developed to prevent or reduce burn injury progression.

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Optimization of the Ultrasound‐Assisted Extraction of Phenolic Antioxidants from Cistus Salvifolius L. Using Response Surface Methodology

Christou,

Nikola,

Goulas

2024

Chemistry & Biodiversity

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The current work aims to optimize the ultrasound‐assisted extraction (UAE) of Cistus salviifolius L. (aerial parts) antioxidative phenolic compounds using response surface methodology. A Box–Behnken design has been conducted to investigate the effect of four factors, namely: (i) percentage of ethanol (50‐90%, v/v), (ii) temperature (40‐80°C), (iii) solvent‐solid ratio (10‐50 mL g‐1) and (iv) extraction time (5‐25min) on four responses, namely: total phenolic content (TPC), total flavonoid content (TFC) 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical inhibition, and ferric reducing antioxidant power (FRAP). Based on the desirability index, UAE with 50% (v/v) ethanol, at 80 oC, using a solvent‐solid ratio of 32.24 mL g‐1, for 21 min resulted in the maximum recovery of phenolic antioxidants. Under optimum conditions, the experimental values of TPC, TFC, % DPPH scavenging activity, and FRAP were 171.67 ± 4.69 mg GAE g‐1, 26.87 ± 0.78 mg CE g‐1, 81.31 ± 0.16%, and 1038.22 ± 7.69 μmol TE g‐1, respectively. Results highlight that the developed eco‐friendly method is appropriate for the improved recovery of phenolic antioxidants from C. salviifolius L.

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Phytochemical profile, in vivo anti-inflammatory and wound healing activities of the aqueous extract from aerial parts of Cistus ladanifer L

Cited by 5 publications

References 31 publications

Wound Healing Properties of Natural Products: Mechanisms of Action

Wound Healing Properties of Natural Products: Mechanisms of Action

Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties

Optimization of the Ultrasound‐Assisted Extraction of Phenolic Antioxidants from Cistus Salvifolius L. Using Response Surface Methodology

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