Phytochemical Profile of Prunus africana Stem Bark from Kenya

DW, Nyamai; AM, Mawia

doi:10.4172/2472-0992.1000110

“…Due to this, study interests have switched to finding a safer remedy with no/less harmful side effects by means of natural-derived entities found in plants as an alternative to synthetic 5αRis. Plants are constituted of numerous bioactive compounds and are proven to have various powerful medicinal properties that could contribute significantly towards a healthier life (Mohan et al, 2011;Sathishkumar & Baskar, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Traditional plants are known to be in medicinal practices for treatment of various diseases since ancient times (Falodun, 2010;Leroi-Gourhan, 1975;Pan et al, 2014) and the use of medicinal plants in the search of new drugs from nature has increased since then (Savithramma et al, 2011). Plants contain numerous bioactive compounds for treatment of many conditions, including cancer (Mohan et al, 2011). The plant kingdom is comprised of approximately 250,000 plant species and only around 10% have been studied for the treatment of different diseases (Iqbal et al, 2017).…”

Section: Revisedmentioning

confidence: 99%

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Azizi

¹

,

Mumin

²

,

Shafqat

³

2021

F1000Res

0

View full text Add to dashboard Cite

Prostate cancer (CaP) is one of the leading causes of death in men worldwide. Much attention has been given on its prevention and treatment strategies, including targeting the regulation of 5-alpha-Reductase (5αR) enzyme activity, aimed to limit the progression of CaP by inhibiting the conversion of potent androgen dihydrotestosterone from testosterone that is thought to play a role in pathogenesis of CaP, by using the 5-alpha-Reductase inhibitors (5αRis) such as finasteride and dutasteride. However, 5αRis are reported to exhibit numerous adverse side effects, for instance erectile dysfunction, ejaculatory dysfunction and loss of libido. This has led to a surge of interests on plant-derived alternatives that might offer favourable side effects and less toxic profiles. Phytochemicals from plants are shown to exhibit numerous medicinal properties in various studies targeting many major illnesses including CaP. Therefore, in this review, we aim to discuss on the use of phytochemicals namely phytosterols, polyphenols and fatty acids, found in various plants with proven anti-CaP properties, as an alternative herbal CaP medicines as well as to outline their inhibitory activities on 5αRs isozymes based on their structural similarities with current 5αRis as part of CaP treatment approaches.

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“…Traditional plants are known to be in medicinal practices for treatment of various diseases since ancient times (Falodun, 2010;Leroi-Gourhan, 1975;Pan et al, 2014) and the use of medicinal plants in the search of new drugs from nature has increased since then (Savithramma et al, 2011). Plants contain numerous bioactive compounds for treatment of many conditions, including cancer (Mohan et al, 2011). The plant kingdom is comprised of approximately 250,000 plant species and only around 10% have been studied for the treatment of different diseases (Iqbal et al, 2017).…”

Section: A New Table (Now Referred As Tablementioning

confidence: 99%

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Azizi

¹

,

Mumin

²

,

Shafqat

³

2021

View full text Add to dashboard Cite

Prostate cancer (CaP) is one of the leading causes of death in men worldwide. Much attention has been given on its prevention and treatment strategies, including targeting the regulation of 5-alpha-Reductase (5αR) enzyme activity, aimed to limit the progression of CaP by inhibiting the conversion of potent androgen dihydrotestosterone from testosterone that is thought to play a role in pathogenesis of CaP, by using the 5-alpha-Reductase inhibitors (5αRis) such as finasteride and dutasteride. However, 5αRis are reported to exhibit numerous adverse side effects, for instance erectile dysfunction, ejaculatory dysfunction and loss of libido. This has led to a surge of interest on plant-derived alternatives that might offer favourable side effects and less toxic profiles. Phytochemicals from plants are shown to exhibit numerous medicinal properties in various studies targeting many major illnesses including CaP. Therefore, in this review, we aim to discuss the use of phytochemicals namely phytosterols, polyphenols and fatty acids, found in various plants with proven anti-CaP properties, as an alternative herbal CaP medicines as well as to outline their inhibitory activities on 5αRs isozymes based on their structural similarities with current 5αRis as part of CaP treatment approaches.

show abstract

“…Glycine max, Lupinus (Jlan, 2009), (Spagnuolo et al, 2015), (Zhang et al, 2016) et al, 2007), (Nyamai et al, 2015) (Komakech et al, 2017 in different remedies which were used to treat different human diseases (Salvamani et al, 2014). PP exert various pharmacological effects such as anti-oxidant, anti-hypertensive, anti-inflammatory and anti-thrombotic activity that can further help in promoting human health (Hollman et al, 1997;Kleemann et al, 2011;Manach et al, 2005;Vinson et al, 1995).…”

Section: In Vitromentioning

confidence: 99%

“…Another study also demonstrated LNA effects on CaP cell proliferation where it inhibited cell viability in PC-3 and LNCaP cell lines (Eser et al, 2013). Prunus Africana bark extracts, where amongst the major compounds identified are MA, LA and LNA, exhibit a very strong anti-androgenic activity and can prevent proliferation and kill CaP tumour cells (Nyamai et al, 2015). Oils of Cocoz Nucifera and Helianthus annuus contains unsaturated FA, OA, and LNA as their major components (de Lourdes Arruzazabala et al, 2007;Sheeba et al, 2015).…”

Section: Fatty Acidsmentioning

confidence: 99%

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Azizi

¹

,

Mumin

²

,

Shafqat

³

2021

F1000Res

3

0

View full text Add to dashboard Cite

Prostate cancer (CaP) is one of the leading causes of death in men worldwide. Much attention has been given on its prevention and treatment strategies, including targeting the regulation of 5-alpha-Reductase (5αR) enzyme activity, aimed to limit the progression of CaP by inhibiting the conversion of potent androgen dihydrotestosterone from testosterone that is thought to play a role in pathogenesis of CaP, by using the 5-alpha-Reductase inhibitors (5αRis) such as finasteride and dutasteride. However, 5αRis are reported to exhibit numerous adverse side effects, for instance erectile dysfunction, ejaculatory dysfunction and loss of libido. This has led to a surge of interests on plant-derived alternatives that might offer favourable side effects and less toxic profiles. Phytochemicals from plants are shown to exhibit numerous medicinal properties in various studies targeting many major illnesses including CaP. Therefore, in this review, we aim to discuss on the use of phytochemicals namely phytosterols, polyphenols and fatty acids, found in various plants with proven anti-CaP properties, as an alternative herbal CaP medicines as well as to outline their inhibitory activities on 5αRs isozymes based on their structural similarities with current 5αRis as part of CaP treatment approaches.

show abstract

Phytochemical Profile of Prunus africana Stem Bark from Kenya

Cited by 9 publications

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Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

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