Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Balkrishna, Acharya; Thakur, Pooja; Varshney, Anurag

doi:10.3389/fphar.2020.00171

Cited by 36 publications

(26 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The utilization and valorization of phytochemicals have focused on nutraceutical use. Hence, the modes-of-action, pharmacological attributes, and medicinal properties target multiple common therapeutic areas, such as neuroprotective, antioxidant, analgesic, immunomodulatory, antimicrobial, antidiabetic and cardioprotective activities ( Figure 2 ) [ 56 ]. Neuroprotection is attributed to high levels of antioxidants, including tungmadic acid, quercetin, and chlorogenic acid, enabling the scavenging of reactive oxygen species (ROS), e.g., H 2 O 2 , efficiently.…”

Section: Nutraceutical and Pharmacological Mode-of-action Of Key Secondary Metabolites In Halophytesmentioning

confidence: 99%

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

et al. 2021

View full text Add to dashboard Cite

The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.

show abstract

Section: Nutraceutical and Pharmacological Mode-of-action Of Key Secondary Metabolites In Halophytesmentioning

confidence: 99%

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Shankhpushpi, or Convolvulus pluricaulis (Cp), is used for nerve regeneration and for improvement of memory [ 68 , 70 , 91 , 136 ]. The major chemical components include triterpenoids, flavonol glycosides, anthocyanins, and steroids, which are responsible for Cp’s nootropic and memory-enhancing properties [ 67 , 68 , 69 , 137 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Gregory¹,

et al. 2021

View full text Add to dashboard Cite

Background—Alzheimer’s disease (AD) is a multifactorial, progressive, neurodegenerative disease that is characterized by memory loss, personality changes, and a decline in cognitive function. While the exact cause of AD is still unclear, recent studies point to lifestyle, diet, environmental, and genetic factors as contributors to disease progression. The pharmaceutical approaches developed to date do not alter disease progression. More than two hundred promising drug candidates have failed clinical trials in the past decade, suggesting that the disease and its causes may be highly complex. Medicinal plants and herbal remedies are now gaining more interest as complementary and alternative interventions and are a valuable source for developing drug candidates for AD. Indeed, several scientific studies have described the use of various medicinal plants and their principal phytochemicals for the treatment of AD. This article reviews a subset of herbs for their anti-inflammatory, antioxidant, and cognitive-enhancing effects. Methods—This article systematically reviews recent studies that have investigated the role of neuroprotective herbs and their bioactive compounds for dementia associated with Alzheimer’s disease and pre-Alzheimer’s disease. PubMed Central, Scopus, and Google Scholar databases of articles were collected, and abstracts were reviewed for relevance to the subject matter. Conclusions—Medicinal plants have great potential as part of an overall program in the prevention and treatment of cognitive decline associated with AD. It is hoped that these medicinal plants can be used in drug discovery programs for identifying safe and efficacious small molecules for AD.

show abstract

“…Convolvulus pluricaulis extract is one of the most widely used neuropharmacological agent that significantly improved learning and memory in experimental models 34,51,52 . It has been employed in treatment of dementia, phobias and insomnia, and successfully tried in PD cases 53 . C. pluricaulis also has been found to ameliorate tau induced neurotoxicity in Alzheimer's disease 54 .…”

Section: Discussionmentioning

confidence: 99%

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

et al. 2020

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a neuromotor disorder, primarily manifested by motor anomalies due to progressive loss of dopaminergic neurons. Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis. Involvement of oxidative stress in PD is further substantiated through ROS induced Parkinsonian models and elevated oxidative markers in clinical PD samples; thereby, making modulation of neuronal oxidative load as one of the major approaches in management of PD. Here we have found a potent antioxidant moiety Scopoletin (Sp), a common derivative in most of the nootropic herbs, with robust neuroprotective ability. Sp increased cellular resistance to ROS through efficient recycling of GSH to prevent oxidative damage. The Sp treated cells showed higher loads of reduced glutathione making them resistant to perturbation of antioxidant machinery or neurotoxin MPP+. Sp could restore the redox balance, mitochondrial function, and prevented oxidative damage, leading to recovery of dopaminergic neural networks and motion abilities in Drosophila genetic model of PD. Our data also suggest that Sp, in combination increases the therapeutic potency of L-DOPA by mitigating its chronic toxicity. Together, we highlight the possible ability of Sp in preventing oxidative stress mediated loss of dopaminergic neurons and at the same time enhance the efficacy of dopamine recharging regimens.

show abstract

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Cited by 36 publications

References 72 publications

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

Contact Info

Product

Resources

About