Phytochemical profiles, antioxidant and antimicrobial activity of Actinidia polygama and A. arguta fruits and leaves

Хромых, Н. О.; Lykholat, Y. V.; Дідур, О. О.; Sklyar, Т. V.; Davydov, V. R.; Lavrentievа, K. V.; Lykholat, T. Y.

doi:10.15421/012205

Cited by 13 publications

(6 citation statements)

References 43 publications

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“…The primary raw material from Acnitidia shrubs is its fruits, which are rich in polyphenols and vitamin C [24]. However, it should be noted that in most cases, secondary metabolites with biological activity in plants are stored in all parts.…”

Section: Resultsmentioning

confidence: 99%

Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves

et al. 2022

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Five varieties of Actinidia leaves (Geneva, Jumbo, Ken’s Red, Kijivska Hibridna, and Sentyabraskaya) were analyzed. The profiles of active compounds were determined, namely quercetin, rutin, epicatechin, chlorogenic acid, and kaempferol, in the raw material. Suspecting that the raw material might prove important in the treatment of diabetes, the authors assessed the antioxidant activity and the ability to inhibit enzymes responsible for the development of diabetes (α-glucosidase and α-amylase). As a result of the conducted analysis, the Ken’s Red variety was indicated as having the highest biological activity (DPPH IC50 = 0.332 ± 0.048; FRAP IC0.5 = 0.064 ± 0.005; α-glucosidase inhibition IC50 = 0.098 ± 0.007; α-amylase inhibition IC50 = 0.083 ± 0.004). In order to increase the efficiency of the extraction of active compounds from Ken’s Red variety leaves, cyclodextrins (α-CD, β-CD, and γ-CD) were used as extraction process enhancers. The obtained results showed a significant increase in the contents of extracted active compounds. In addition, the type of CD used enhanced the extraction of selected compounds (quercetin, kaempferol, rutin, chlorogenic acid, and epicatechin. This study shows that the application of cyclodextrin-based extraction significantly improved the leaf activity of the Ken’s Red variety (DPPH IC50 = 0.160 ± 0.019; FRAP IC0.5 = 0.008 ± 0.001; α-glucosidase inhibition IC50 = 0.040 ± 0.002; α-amylase inhibition IC50 = 0.012 ± 0.003).

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Section: Resultsmentioning

confidence: 99%

Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves

et al. 2022

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“…The crude extracts of A. arguta fruit and leaves notably inhibited clinical strains of Pseudomonas aeruginosa and Escherichia coli, which were resistant to the action of ofloxacin. The inhibitory effects of the plant extracts on clinical strains of Klebsiella pneumoniae and Acinetobacter baumannii were comparable with the effect of ofloxacin [70]. In addition, Macedo et al (2023) studied an extract of A. arguta, which displayed antimicrobial activities against Staphylococcus aureus (MIC = 32 mg/mL) and Pseudomonas gingivalis (MIC = 64 mg/mL) and reduced the growth rate of Escherichia coli [71].…”

Section: Other Pharmacological Effectsmentioning

confidence: 91%

“…Khromykh et al (2022) studied the antioxidant activities of components such as polyphenols in the peels and pulps of A. arguta. The results indicated that the peels had stronger reducing power and total antioxidant capacity compared with the pulps [70]. The best processing extract of A. arguta exhibited exceptional antioxidant and antiradical activities, including ABTS, ferric-reducing antioxidant power (FRAP), superoxide anion radical, hypochlorous acid, and peroxyl radical scavenging [71].…”

Section: Antioxidant Activitymentioning

confidence: 98%

Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq.: A Review of Phytochemistry and Pharmacology

Zhang,

Teng,

Zang

2023

Molecules

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Actinidia arguta (Siebold & Zucc.) Planch ex Miq. (A. arguta) is a highly valued vine plant belonging to the Actinidia lindl genus. It is extensively utilized for its edible and medicinal properties. The various parts of A. arguta serve diverse purposes. The fruit is rich in vitamins, amino acids, and vitamin C, making it a nutritious and flavorful raw material for producing jam, canned food, and wine. The flowers yield volatile oils suitable for essential oil extraction. The leaves contain phenolic compounds and can be used for tea production. Additionally, the roots, stems, and leaves of A. arguta possess significant medicinal value, as they contain a wide array of active ingredients that exert multiple pharmacological and therapeutic effects. These effects include quenching thirst, relieving heat, stopping bleeding, promoting blood circulation, reducing swelling, dispelling wind, and alleviating dampness. Comprehensive information on A. arguta was collected from scientific databases covering the period from 1970 to 2023. The databases used for this review included Web of Science, PubMed, ProQuest, and CNKI. The objective of this review was to provide a detailed explanation of A. arguta from multiple perspectives, such as phytochemistry and pharmacological effects. By doing so, it aimed to establish a solid foundation and propose new research ideas for further exploration of the plant’s potential applications and industrial development. To date, a total of 539 compounds have been isolated and identified from A. arguta. These compounds include terpenoids, flavonoids, phenolics, phenylpropanoids, lignin, organic acids, volatile components, alkanes, coumarins, anthraquinones, alkaloids, polysaccharides, and inorganic elements. Flavonoids, phenolics, alkaloids, and polysaccharides are the key bioactive constituents of A. arguta. Moreover, phenolics and flavonoids in A. arguta exhibit remarkable antioxidant, anti-inflammatory, and anti-tumor properties. Additionally, they show promising potential in improving glucose metabolism, combating aging, reducing fatigue, and regulating the immune system. While some fundamental studies on A. arguta have been conducted, further research is necessary to enhance our understanding of its mechanism of action, quality evaluation, and compatibility mechanisms. A more comprehensive investigation is highly warranted to explore the mechanism of action and expand the range of drug resources associated with A. arguta. This will contribute to the current hot topics of anti-aging and anti-tumor drug research and development, thereby promoting its further development and utilization.

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“…За дії полютантів різного походження на живі організми проявляються неспецифічні реакції, однією з яких є посилення вільно-радикальних процесів та підвищення активності антиоксидантних ферментів, зокрема супероксиддисмутази (Lykholat & Chernaya, 1999;Ahmad et al, 2010;Boran & Ugur, 2017;Hasanuzzaman at al., 2017;Lykholat et al, 2019;Li et al, 2020;Jadczak Sanna et al, 2020;Khromykh et al, 2022;Sanna et al, 2022).…”

Section: вступunclassified

Dynamics of SOD activity and accumulation of TBA-active products in the process of ontogeny of some sod-forming plants in a megalopolis

Boroday,

Lykholat,

Lykholat

2023

ean

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In the conditions of a modern metropolis, green spaces are an integral planning structure, which the issues of not only improving the aesthetics of the city's architecture, but also improving the environmental safety of the population are solved. Lawn grasses play a significant role in improving the microclimate of urban areas; the harmful concentration of gases in the air decreases, the regulation of the thermal regime and humidity is observed. Since almost half of the urban area is occupied by sod-forming plants, it is relevant to study the resistance of these species to anthropogenic impact in an urbanized environment. The aim of the work was to assess the state of the antioxidant system, namely the activity of superoxide dismutase (EC 1.15.1.11), and the accumulation of TBA-active products in the process of ontogeny of sod-forming plants growing in a metropolis. The objects of the study were Setaria viridis (L.) Beauv.) and Elytrígia répens (L.) Nevski.). It has been established that due to oxidative stress caused by vehicle emissions and industrial aeropollutants, there is an intensification of lipid peroxidation processes in the vegetative organs of Setaria viridis, Elytrigia repens during all phases of ontogeny. According to the results of the research, it was found that Elytrigia repens was more stable in terms of the content of TBA-active products (the level of the indicator in leaves was 30–50 %, roots – 20–44 % higher than the control indices) compared to Setaria viridis, for which the excess was 50–70 % (leaves) and 40–62 % (roots). SOD activity is an indicator of resilience to stressors and varies with the duration and intensity of stressors. The obtained results indicate that the enzyme activity of experimental plants in the generative state (increase in enzyme activity by 47.5–38 % in Elytrigia repens, by 74–62.5 % in Setaria viridis) in contaminated areas was higher than in virginile individuals (SOD activity levels: Elytrigia repens (37.5–26.5 %), Setaria viridis (60–50 %). The presence of close correlations between the activity of SOD and the content of TBA-active products characterizing the adaptive potential of plant organisms in the vegetative organs of the studied species was established.

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Phytochemical profiles, antioxidant and antimicrobial activity of Actinidia polygama and A. arguta fruits and leaves

Cited by 13 publications

References 43 publications

Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves

Assisted Extraction with Cyclodextrins as a Way of Improving the Antidiabetic Activity of Actinidia Leaves

Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq.: A Review of Phytochemistry and Pharmacology

Dynamics of SOD activity and accumulation of TBA-active products in the process of ontogeny of some sod-forming plants in a megalopolis

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