Phytochemical profiling and ameliorative effects of Achillea cretica L. on rat model of endometriosis

Bina, Fatemeh; Daglia, Maria; Santarcangelo, Cristina; Baeeri, Maryam; Abdollahi, Mohammad; Nabavi, Seyed Mohammad; Tabarrai, Malihe; Rahimi, Roja

doi:10.1016/j.jep.2020.112747

Cited by 11 publications

(14 citation statements)

References 58 publications

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“…A. millefolium has been used in folk medicine in Pakistan and Iran for wound healing. In Italy and Turkey not only A. millefolium but several other Achillea species extracts were traditionally administered as wound healing agents [ 13 , 14 ]. Unani, medicine of India, concerned the activity of A. millefolium and described its significant role in traditional medicine and a successful administration in the treatment of inflammatory conditions and pain (wounds, cuts, and abrasions) that could be relieved by the application of lotions or ointments containing common yarrow extracts [ 7 , 15 ].…”

Section: Traditional Application Of Achillea Spmentioning

confidence: 99%

Achillea Species as Sources of Active Phytochemicals for Dermatological and Cosmetic Applications

Strzępek-Gomółka

Gaweł-Bęben

Kukuła-Koch

2021

Oxidative Medicine and Cellular Longevity

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Achillea spp. is well known for its broad range of applications and long history of use in traditional medicine around the world. Health benefits of Achillea extracts result from the multitude of secondary metabolites identified in the plants from this genus that include flavonoids, phenolic acids, terpenes, guaianolides, phytosterols, fatty acids, and organic acids. The properties of several Achillea extracts meet also the expectations of a vividly developing cosmetic market. An increasing number of studies on the dermatological properties of Achillea spp. are observed in the recent years, with Achillea millefolium L. being the most studied and used representative of the genus. There is strong scientific evidence showing that also other yarrow species might be rich sources of effective cosmetic ingredients, with skin calming and rejuvenating properties, wound healing activity, and anti-inflammatory potential. Several Achillea extracts and isolated compounds were also shown to display significant tyrosinase inhibitory, antioxidant, and antimicrobial properties and thus are interesting candidates for active ingredients of medications and cosmetic products protecting the skin from the harmful impact of environmental stressors. The aim of this review is to collect the current information on the composition and cosmeceutical significance of different Achillea species.

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Section: Traditional Application Of Achillea Spmentioning

confidence: 99%

Achillea Species as Sources of Active Phytochemicals for Dermatological and Cosmetic Applications

Strzępek-Gomółka

Gaweł-Bęben

Kukuła-Koch

2021

Oxidative Medicine and Cellular Longevity

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“…A total of 286 studies were initially identified by the search criteria. After applying the selection criteria, a total of 60 trials were included in the systematic review [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ,…”

Section: Resultsmentioning

confidence: 99%

“…Oral isoliquiriteginin (ISL), a flavonoid found in liquorice, has been found not only to decrease lesion volume but also to reduce serum and tissue VEGF, IL1β and IL-6 and to increase Bax, Bcl-2 and E-cadherin [ 72 ]. Other authors have investigated the effect of a daidzein-rich isoflavone aglycones diet [ 57 ] or of extract of different plants known to contain several PE such as Achileea bierbersteinii [ 39 ], Urtica dioica and Anthemis austriaca [ 62 , 63 ], Melilotus officinalis [ 73 ] and Achillea critica [ 70 ] on endometriosis lesions. All of them have been found to decrease the volume of lesion and adhesion scores.…”

Section: Resultsmentioning

confidence: 99%

“…All of them have been found to decrease the volume of lesion and adhesion scores. Also, decreased concentration TNF-α were observed both in peritoneal [ 62 , 63 ] and in serum and tissue samples [ 70 ]. Moreover, Urtica dioica, Anthemis austriaca, Melilotus officinalis and Achillea critica (AC) extract were able to reduce peritoneal VEGF and IL-6 compared to controls.…”

Section: Resultsmentioning

confidence: 99%

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Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review

et al. 2021

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The aim of this systematic review was to provide comprehensive and available data on the possible role of phytoestrogens (PE) for the treatment of endometriosis. We conducted an advanced, systematic search of online medical databases PubMed and Medline. Only full-length manuscripts written in English up to September 2020 were considered. A total of 60 studies were included in the systematic review. According to in vitro findings, 19 out of 22 studies reported the ability of PE in inducing anti-proliferative, anti-inflammatory and proapoptotic effects on cultured cells. Various mechanisms have been proposed to explain this in vitro action including the alteration of cell cycle proteins, the activation/inactivation of regulatory pathways, and modification of radical oxidative species levels. Thirty-eight articles on the effects of phytoestrogens on the development of endometriotic lesions in in vivo experimental animal models of endometriosis have been included. In line with in vitro findings, results also derived from animal models of endometriosis generally supported a beneficial effect of the compounds in reducing lesion growth and development. Finally, only seven studies investigated the effects of phytoestrogens intake on endometriosis in humans. The huge amount of in vitro and in vivo animal findings did not correspond to a consistent literature in the women affected. Therefore, whether the experimental findings can be translated in women is currently unknown.

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“…The total phenolic content was determined by using the Folin-Ciocalteu assay and was expressed as mg Gallic acid Equivalents (GAE). Total flavonoid content was measured by the aluminium chloride colorimetric assay and was expressed as mg quercetin equivalents (QE) [ 12 ]. Total phenolic and flavonoid contents of each ml of syrup were estimated to be equivalent to 185.22 ± 0.71 mg gallic acid and 103.64 ± 1.32 mg quercetin, respectively.…”

Section: Main Textmentioning

confidence: 99%

The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial

et al. 2021

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Objective Psoriasis is an immune-mediated inflammatory skin disease. It can involve any body skin area, particularly the scalp, lower back, elbows, and knees. There are several topical and systemic therapies for the treatment. Nowadays, herbal medicines are popular treatments for dermatologic conditions. This two-arm parallel, randomized placebo-controlled clinical trial was conducted to examine the hypothesis of the efficacy of Melissa officinalis syrup on patients with mild-to-moderate Plaque psoriasis. Result Among 100 patients, 95 participants completed the trial and five of them withdrew. The mean pruritus intensity and PASI scores decreased significantly in the intervention group compared to the placebo group (P < 0.001). The DLQI score in the intervention group increased post-treatment compared to pre-treatment (P = 0.029); however, there was no significant difference between the intervention and control group at the end of the study (0.065). Trial registration: The trial was registered in the Iranian registry of clinical trials on November 9th, 2019 (https://www.irct.ir/trial/43434; registration number: IRCT20191104045326N1).

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Phytochemical profiling and ameliorative effects of Achillea cretica L. on rat model of endometriosis

Cited by 11 publications

References 58 publications

Achillea Species as Sources of Active Phytochemicals for Dermatological and Cosmetic Applications

Achillea Species as Sources of Active Phytochemicals for Dermatological and Cosmetic Applications

Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review

The effect of Melissa officinalis syrup on patients with mild to moderate psoriasis: a randomized, double-blind placebo-controlled clinical trial

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