Phytochemical profiling of methanolic extract of Periploca aphylla Decne. using GC-MS analysis

Rashid, Umer; Khan, Muhammad Rashid; Bokhari, Jasia; Jan, Shumaila; Shah, Naseer Ali

doi:10.30574/wjarr.2022.16.1.0965

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Various constituents separated from P. aphylla have exhibited inhibitory effects against α-glucosidase type VI. 17 Researchers are currently investigating and reporting 18,19 different phytochemicals and biological attributes of P. aphylla. However, a comprehensive study is still needed to bridge existing gaps in knowledge.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Biological Activity and Pharmacological Attributes of Pariploca aphylla: Potential Source of Functional Food and Nutraceuticals

YOUNAS,

IQBAL,

SALEEM

et al. 2023

Rev.Roum.Chim.

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Functional foods and nutraceuticals are gaining popularity as they are being developed and commercialized with the aim of reducing the risk of various diseases and their treatment. In this study, antiradical activity guided fractionation of Pariploca aphylla (P. aphylla) crude extract was conducted. A crude methanolic extract of P. aphylla was prepared and then fractionated using different solvents, including hexane, chloroform, ethyl acetate, butanol, and water. This approach allowed for the isolation and characterization of different fractions of P. aphylla with potential antioxidant activity. These fractions were tested for the determination of total phenolic content, antiradical (DPPH• and ABTS•+) potential and HPLC quantification of phenolic acids. Among all the tested fractions, butanol fraction exhibited highest phenolic content and significant antiradical potential. Butanol faction was further sub-fractionated using a silica gel-loaded column and 18 sub-fractions were obtained. Antiradical potential of all 18 sub-fractions was determined and sub-fraction 12 was found having highest radical scavenging potential. Structures of compounds in sub-fraction 12 were identified and quantified using GC-MS. Among all the identified compounds, 7-Trimethylsilyloxytridecane (C16H36OSi) and 1,2-bis(trimethylsiloxy)ethane (C8H22O2Si2) were found in highest ratio. All of the compounds can be declared having high anti-radical potential that can be extracted or synthesized for possible exploitation as functional food or nutraceuticals.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Biological Activity and Pharmacological Attributes of Pariploca aphylla: Potential Source of Functional Food and Nutraceuticals

YOUNAS,

IQBAL,

SALEEM

et al. 2023

Rev.Roum.Chim.

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Exploration of Medicinal Properties and Metabolite Diversity Between Different Petiole Types of Simarouba Glauca: A Nontargeted Metabolomics Approach

Kandaswamy,

Kannathasan,

Selvakumar

et al. 2024

Environmental Quality Mgmt

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Comparative metabolomics is a powerful technique to unveil variabilities in metabolic composition between different plant types of the same species. Thus, unveiling the unique and common metabolites between plant types and unique medicinal properties has the potential to utilize the specific plant type in modern medicine. However, up to date, no study reports metabolite composition and medicinal properties of different color petiole types of Simarouba glauca (S. glauca), which is known for its potential pharmaceutical properties. In this study, we aimed to perform a metabolomic investigation on two different petiole types of S. glauca to unveil the unique and common metabolites and their therapeutic properties between these petiole plant types. In specific, we conducted a comprehensive metabolomic analysis of the green petiole (GP) and red petiole (RP) of S. glauca, that revealed 43 unique metabolites between both petiole types. The differentially accumulated metabolite analysis disclosed five differentially accumulated metabolites between RP and GP, in which two are highly accumulated in GP (4‐Amino‐1,5‐pentandioic acid and 2‐Myristynoyl pantetheine), and one (5‐Hydroxymethylfurfural) in RP. Furthermore, the chemical classification of identified metabolites resulted in 27 distinct chemical classes, with fatty acids and amino acids being notably enriched. Functional annotation highlighted the wound healing and antibacterial attributes of GP and the antipruritic and antiviral properties of RP. The pathway enrichment analysis revealed the involvement of the identified metabolites in cutin, suberin, and wax biosynthesis, along with fatty acid biosynthesis. Moreover, RP exhibited a higher abundance of anticancer metabolites compared to GP. Overall, the findings of this study offer valuable insights into the metabolic disparities, metabolite role in color variation, and medicinal potentials of different petiole types of S. glauca and underscore their promising pharmaceutical applications.

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Phytochemical profiling of methanolic extract of Periploca aphylla Decne. using GC-MS analysis

Cited by 2 publications

References 25 publications

Evaluation of Biological Activity and Pharmacological Attributes of Pariploca aphylla: Potential Source of Functional Food and Nutraceuticals

Evaluation of Biological Activity and Pharmacological Attributes of Pariploca aphylla: Potential Source of Functional Food and Nutraceuticals

Exploration of Medicinal Properties and Metabolite Diversity Between Different Petiole Types of Simarouba Glauca: A Nontargeted Metabolomics Approach

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