Phytochemical review of Juncus L. genus (Fam. Juncaceae)

Elshamy, Abdelsamed I.; Abdel-Razek, Ayman F.; Nassar, Mahmoud I.

doi:10.1016/j.arabjc.2012.07.007

Cited by 47 publications

(33 citation statements)

References 23 publications

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“…Juncus species are known to contain secondary metabolites of different classes, namely coumarins, flavonoids, sterols, terpenes, phenolic acids, stilbenes, carotenoids and phenanthrenes [2,31]. The rhizomes of J. acutus are known to contain phenanthrenoids with anti-inflammatory activity [33], while the aerial parts are endowed with phenolic glycosides displaying anti-eczematic activity [13].…”

Section: Resultsmentioning

confidence: 99%

Maritime Halophyte Species from Southern Portugal as Sources of Bioactive Molecules

et al. 2014

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Extracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC50 = 0.1 mg/mL) and J. acutus (IC50 = 0.4 mg/mL), and the ether extracts of J. acutus (IC50 = 0.2 mg/mL) and A. macrostachyum (IC50 = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC50 = 0.4 mg/mL) and H. portulacoides (IC50 = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC50 = 109 µg/mL) and the hexane extract of P. coronopus (IC50 = 98.0 µg/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells.

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Section: Resultsmentioning

confidence: 99%

Maritime Halophyte Species from Southern Portugal as Sources of Bioactive Molecules

et al. 2014

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“…These compounds are biosynthesized by a limited number of botanical families. Orchidaceae and Juncaceae are the main botanical families known to produce this kind of natural product (31,32). Phenanthrenes and 9,10-dihydrophenanthrenes showed a large panel of biological activities, including, among others, cytotoxic, antimicrobial, spasmolytic, and anti-inflammatory activities.…”

Section: Discussionmentioning

confidence: 99%

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus , Is a New Inhibitor of Hepatitis C Virus RNA Replication

Sahuc

Sahli

Rivière

et al. 2019

J Virol

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Recent emergence of direct-acting antivirals (DAAs) targeting hepatitis C virus (HCV) proteins has considerably enhanced the success of antiviral therapy. However, the appearance of DAA-resistant-associated variants is a cause of treatment failure, and the high cost of DAAs renders the therapy not accessible in countries with inadequate medical infrastructures. Therefore, the search for new inhibitors with a lower cost of production should be pursued. In this context, the crude extract of Juncus maritimus Lam. was shown to exhibit high antiviral activity against HCV in cell culture. Bio-guided fractionation allowed the isolation and identification of the active compound, dehydrojuncusol. A time-of-addition assay showed that dehydrojuncusol significantly inhibited HCV infection when added after virus inoculation of HCV genotype 2a (50% effective concentration [EC50] = 1.35 µM). This antiviral activity was confirmed with an HCV subgenomic replicon, and no effect on HCV pseudoparticle entry was observed. Antiviral activity of dehydrojuncusol was also demonstrated in primary human hepatocytes. No in vitro toxicity was observed at active concentrations. Dehydrojuncusol is also efficient on HCV genotype 3a and can be used in combination with sofosbuvir. Interestingly, dehydrojuncusol was able to inhibit RNA replication of two frequent daclatasvir-resistant mutants (L31M or Y93H in NS5A). Finally, mutants resistant to dehydrojuncusol were obtained and showed that the HCV NS5A protein is the target of the molecule. In conclusion, dehydrojuncusol, a natural compound extracted from J. maritimus, inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure. IMPORTANCE Tens of millions of people are infected with hepatitis C virus (HCV) worldwide. Recently marketed direct-acting antivirals (DAAs) targeting HCV proteins have enhanced the efficacy of treatment. However, due to its high cost, this new therapy is not accessible to the vast majority of infected patients. Furthermore, treatment failures have also been reported due to the appearance of viral resistance. Here, we report on the identification of a new HCV inhibitor, dehydrojuncusol, that targets HCV NS5A and is able to inhibit RNA replication of replicons harboring resistance mutations to anti-NS5A DAAs used in current therapy. Dehydrojuncusol is a natural compound isolated from Juncus maritimus, a halophilic plant species that is very common in coastlines worldwide. This molecule might serve as a lead for the development of a new therapy that is more accessible to hepatitis C patients in the future.

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“…In this study it was observed in all three studied areas. It is a plant species with wide distribution in different climatic conditions in the world, from salt marshes, fresh water edges to badly irrigated lands [32]. The presence of this species has been previously reported in wetlands in the Karkamiş District of Gaziantep [33].…”

Section: Discussionmentioning

confidence: 99%

“…Their importance might have also contributed to their distribution in the area. For example, Salsola species are reported to be used in soap and detergent production [20], while Juncus species are reported to be used in mop production, paper industry, cellulose and nitrocellulose production [32]. In pharmaceuticals, Salsola kali L. also is reported to be used as a diuretic, stimulant and in the treatment of obstetrics and edema [20].…”

Section: Discussionmentioning

confidence: 99%

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Halophytic Species in Natural Areas Close to Agricultural Areas of Araban (Gaziantep, Turkey)

Tunç¹,

Tekin²,

Demir³

et al. 2020

JACEN

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As a result of the global warming caused by increasing industrialization, changes in vegetation have occurred on the earth. Halophyte species have been observed in many areas including native vegetation and agricultural land due to increased drought and warming and also over irrigation during formation of secondary vegetation. Soil samples were taken seasonally from selected three areas (Timurlenk, Karapinar and Fakili) in Araban (Gaziantep Turkey) and the pH, electrical conductivity (EC), lime (CaCO 3 ), nitrogen (N), phosphorus (P), potassium (K), sodium (Na) and calcium (Ca) analyzes were performed in this samples. In addition, the presence of taxa known to be halophytes in these areas has been investigated. As a result of the analyses, it was found that there was no seasonal difference (p > 0.05), but there were significant differences between lime (CaCO 3 ), phosphorus (P), potassium (K) and calcium (Ca) among the localities (p < 0.05). Alhagi pseudoalhagi M. Bieb. was found in Timurlenk and Karapinar, Salsola kali spp. ruthenica Iljin was found in Timurlenk and Juncus inflexus L. was found in Timurlenk, Karapinar, Fakili. Although the soil is not salty, the presence of three different taxa that can tolerate the salt in three localities shows that the amount of salt in the soil may increase in time. The information presented in this study contributes to the salinization of soils and their effects on agriculture in the region.

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Phytochemical review of Juncus L. genus (Fam. Juncaceae)

Cited by 47 publications

References 23 publications

Maritime Halophyte Species from Southern Portugal as Sources of Bioactive Molecules

Maritime Halophyte Species from Southern Portugal as Sources of Bioactive Molecules

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus , Is a New Inhibitor of Hepatitis C Virus RNA Replication

Halophytic Species in Natural Areas Close to Agricultural Areas of Araban (Gaziantep, Turkey)

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