Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats

Abstract

Phytochemical screening and antidiabetic effects of fruit rind of Momordica dioica roxb. on streptozocin induced type 2 diabetic rats, HELIYON, https://doi.org/10.1016/j.heliyon.2022.e08771. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Importance of Certain Varieties of Cucurbits in Enhancing Health: A Review

“…In a study comparing the antibacterial and antioxidant activity of the root and fruit extracts of Momordica charantia L. and Momordica dioica Roxb, the antibacterial capacity of the extracts was confirmed, with the antibacterial activity of the fruit extract being greater than that of the root extract for both Gram-negative and Gram-positive bacteria. Additionally, M. charantia and M. dioica inhibited 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals, demonstrating potent antioxidant activity [116]. Treatment with the ethanolic extract of M. dioica in rats with type 2 diabetes modified glycemic and lipidemic conditions, and decreased fasting serum glucose, cholesterol, and triglyceride levels; however, there are no panoptic reports on the primary active phytoconstituents of M. dioica ethanolic extract, so establishing which are responsible for the antidiabetic activity is difficult [117].…”

Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract

“…The Table 3 presents the pre-compression values. According to the USP requirement, all the batches met Angle of repose (25)(26)(27)(28)(29)(30) as Excellent, (31-35) Good, Carr's index (12)(13)(14)(15)(16) as Good, (5-15) Excellent, and Hausner's ratio (1.12-1.18) as Good, (1-1.11) Excellent. So, we draw the conclusion that all of the batches had efficient precompression settings.…”

“…Additionally, several study findings highlighting the potential of M. dioica from diverse angles, such as plant components, animal models, or conventional drugs. 13 Tablets are characterised as solid formulations designed for oral administration and having one or more active components in a single dosage. Compaction is used to create tablets filled with medication and formulation components.…”

Modification with Conventional Surfactants to Improve a Lipid-Based Ionic-Liquid-Associated Transcutaneous Anticancer Vaccine

“…Transcutaneous vaccination is a patient-friendly, effective, and target-specific alternative vaccination/immunization approach because skin contains numerous immunoresponsive antigen-presenting cells (APCs), which are highly efficacious for immunoresponsive diseases such as cancer, anemia, HIV, and diabetes [ 4 , 5 ]. However, the lipidic arrangement of the stratum corneum (SC) hinders the permeation of large and hydrophilic molecules (proteins, peptides, and nucleic acids), which must be transported using a hydrophobic, lipophilic, or oil-based nanocarrier [ 6 , 7 , 8 , 9 ]. Ionic liquids (ILs), which are liquid salts with a melting temperature below 100 °C, can be used as reagents, solvents, and antisolvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs); as solvents, cosolvents, and emulsifiers in drug formulations; as pharmaceuticals (API-ILs) aiming at liquid therapeutics; and in the development and/or improvement of drug-delivery-based systems [ 10 ].…”