Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats

Juárez-Rojop, Isela; Tovilla-Zárate, Carlos Alfonso; Aguilar-Domínguez, Dora E.; Roa, Luis F.; Lobato‐García, Carlos E.; Blé-Castillo, Jorge L.; López‐Meraz, María Leonor; Díaz-Zagoya, Juan C.; Bermúdez-Ocaña, Deysi Y.

doi:10.1016/j.bjp.2014.07.012

Cited by 73 publications

(48 citation statements)

References 30 publications

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“…The lowering of plasma total cholesterol, triglyceride and low density lipoprotein-cholesterol levels and significant increase in high density lipoprotein-cholesterol level in the treated animals clearly confirmed the presence of hypolipidemic agents in the extracts of P. glaucus and standard drug gibenclamide compared to untreated diabetic rats could be inactiva-ting HMG-CoA reductase. The presence of secondary metabolites such as polyphenols, alkaloids, flavonoid, tannins and terpenoidin P. glaucus extract may contri-bute in protecting the ß cells of pancreas and thus producing hypoglycemic and hypolipidemic activity (Juárez-Rojop et al, 2014). The ability of the extracts to manage hyperlipidemia is a potential beneficial effect on cardiovascular risk factors which is a major cause of death in diabetes mellitus .…”

Section: Discussionmentioning

confidence: 99%

Effect of <i>Pericampylus glaucus</i> on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

Kifayatullah

Sengupta

2016

Bangladesh J Pharmacol

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Research Article Effect of Effect of Effect of Pericampylus glaucusPericampylus glaucus Pericampylus glaucus on on on plasma glucose concentration and plasma glucose concentration and plasma glucose concentration and lipid profile in streptozotocin lipid profile in streptozotocin lipid profile in streptozotocin---induced diabetic rats induced diabetic rats induced diabetic rats BJP IntroductionAccording to statistical report around, 382 million people suffered from diabetes mellitus worldwide. It is a chronic metabolic disorder characterized with biochemical alterations of glucose, urine excretion and lipid metabolism (Kamboj et al., 2013). Two main types of diabetes mellitus reported, Type I is commonly known as insulin dependent diabetes mellitus (IDDM) and Type II, is called non-insulin dependent diabetes mellitus (NIDDM) (Patel et al., 2011). A number of side effects have been observed with the use synthetic antidiabetic drugs. The use of natural remedies for the treatment of diabetes has long history. The genus Pericampylus glaucus Lam Merr belongs to the family of Menispermaceae, commonly found in Malaysia (Wiart, 2006). The roots are claimed to be effective against lowering high lipid level and diabetes in Malaysia (Ong et al., 2011). The stems and roots effectively to stops bleeding, arthritis, sore throat, productive cough, colds, headache, abdominal pain, and abdominal distention (Li, 2006).The whole plant, fruits, stem and leaves are also connected for various ailments like for the relief of loss of movement tongue, fever, joint pain, muscles pain, diabetes, constipation, snake biting and edema (Jahan et al., 2010, Azad et al., 2014.Therefore, the present study was aim to determine the effect of P. glaucus on plasma glucose concentration and lipid profiles in streptozotocin-induced diabetic rats. Materials and Methods Collection of plants and ethanol extraction AbstractThe purpose of this study was to evaluate the effects of Pericampylus glaucus extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. The ethanolic extract were administered orally at three different doses (400, 600 and 800 mg/kg) and glibenclamide (20 mg/kg p.o.) for 21 days after 72 hours of streptozotocin injection. During the short-and long-term studies, the extract was found to possess significant (p<0.01, p<0.001) anti-diabetic activity in normal and diabetic rats compared with untreated normal and untreated diabetic group. It also caused reduction in the level of total cholesterol, triglyceride, and LDL etc. and improvement in the HDL level compared with untreated diabetic rats. Reduction in the fasting blood sugar, cholesterol, triglyceride, urea, LDL, creatinine levels and improvement in the HDL by P. glaucus indicates that plant has anti-diabetic activity along with anti hyperlipidemic efficacy and provides a scientific rationale for the use. Article Info

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Section: Discussionmentioning

confidence: 99%

Effect of <i>Pericampylus glaucus</i> on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

Kifayatullah

Sengupta

2016

Bangladesh J Pharmacol

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“…Carica papaya (papaya) originated from the tropical regions of Mexico and America but is now widely distributed throughout the tropics and subtropics of the world [1]. The C. papaya is a fast growing, erect and typically unbranched herbaceous tree, with hollow trunk of about 20 cm in diameter [2].…”

Section: Introductionmentioning

confidence: 99%

“…The ripe or unripe fruit as well as other different parts of C. papaya have been reported to possessing wide range of biological applications [1,[19][20][21][22]. The present study was aimed to identify the phytocomponents of Aqueous Extract of Unripe Fruit (AqEUF) of C. papaya that are likely responsible for its biologic activity using GC-MS analytical protocols.…”

Section: Introductionmentioning

confidence: 99%

GC–MS Analysis of Aqueous Extract of Unripe Fruit of Carica papaya

Ezekwe¹,

Chikezie²

2017

J Nutr Food Sci

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The present study was aimed to identify the likely phytocomponents present in Aqueous Extract of Unripe Fruit (AqEUF) of Carica papaya. The phytocomponents present in AqEUF of C. papaya was identified using GC-MS detection system. The results showed the presence of fifteen phytocomponents in AqEUF of C. papaya. The major phytocomponents present in AqEUF of C. papaya in terms of their relative abundance were octadecanoic acid, hexadecenoic acid, Z-11 and hexadecanoic acid, methyl ester, which corresponded to 23.84%, 19.17% and 18.25% respectively. The relative abundance of minor phytocomponents present in AqEUF of C. papaya was within a narrow range of 0.78-5.38%. The present investigation revealed that AqEUF of C. papaya was composed of variety of metabolites and therapeutic active substances as well as novel substances. These substances could be isolated and further empirically evaluated to confirm their biologic and medicinal activities as well as investigate their mechanism of action.

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“…The flesh part of ripe papaya fruit has sweet and delicate taste, rich with multiple vitamins (C, E and A) and contains an excellent source of folic acid, potassium, copper, phosphorous and iron. Many published clinical evidence had shown the presence of phytochemicals in papaya leaves contributes to its multiple functional role as a remedy for diabetes treatment (Juárez-Rojop et al, 2014), anti-inflammatory effect (Owoyele et al, 2008), immunomodulatory effects (Otsuki et al, 2010), chemopreventive effects (Tan et al, 2014), antiplasmodial effect (Ahmad et al, 2011) and analgetic activity (Hasimun et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Potential of fermented papaya beverage in the prevention of foodborne illness incidence

Koh¹,

Aziz²,

Sharifudin³

et al. 2017

Food Res.

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Foodborne illness is recognized as an emerging infectious disease. The incidence of foodborne infections is common and the majority cases are undiagnosed or unreported. Apart from some diarrhea or minor gastrointestinal problem, some foodborne pathogenic microbes may cause death, particularly to those people with weakened immune system. In this study, we have developed a new fermented papaya beverage using symbiotic culture of yeast and acetic acid bacteria under controlled biofermentation process. An in-vitro assessment of fermented papaya beverage against few foodborne pathogenic microorganism was conducted to determine its minimum bactericidal concentration (MBC >99 ). Three types of foodborne pathogen: Escherichia coli O157, Salmonella enterica serovar Typhimurium ATCC 53648, Salmonella enterica serovar Enteritidis (isolated from infectious chicken) were selected. From minimum bactericidal concentration (MBC >99 ) assay, both fermented papaya pulp and leaves beverages have shown 100% killing rate against three selected foodborne pathogenic microbes. Inversely, non-fermented papaya pulp and leaves beverages indicated no inhibition at all. In fact, further dilution of fermented papaya pulp and leaves beverages demonstrated different degree of MBC >99 and brix value, but the pH value remained less than 3.5. These findings indicated the combination of soluble solid compounds presents in both fermented papaya beverage and product acidity play an important role in the inhibition of pathogenic microorganisms. The preliminary promising results of this work have shown that the great potential of fermented papaya beverages as a preventive measure to reduce the incidence of foodborne illness.

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Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats

Cited by 73 publications

References 30 publications

Effect of <i>Pericampylus glaucus</i> on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

Effect of <i>Pericampylus glaucus</i> on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

GC–MS Analysis of Aqueous Extract of Unripe Fruit of Carica papaya

Potential of fermented papaya beverage in the prevention of foodborne illness incidence

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