Phytochemical screening and in vitro antimicrobial activity of Typha angustifolia Linn leaves extract against pathogenic gram negative micro organisms

Londonkar, Ramesh L; Kattegouga, Umesh Madire; Shivsharanappa, Kirankumar; Hanchinalmath, Jayashree V.

doi:10.1016/j.jopr.2013.02.010

Cited by 26 publications

(25 citation statements)

References 7 publications

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“…In clinic, administration of antibiotics is a frequently used method for prophylaxis and treatment of infections. However, long-term administration of antibiotics easily causes toxic and adverse effects to the human body such as hypersensitivity and immunosuppression; and the abuse of antibiotics has given rise to serious multiple drug resistance of many pathogenic bacteria [4][5][6][7] . Therefore, it is extremely necessary to explore new methods of dealing with the implant-related bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Shuai

Guo

Gao

et al. 2024

IJB

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Bone repair failure caused by implant-related infections is a common and troublesome problem. In this study, an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide (nMgO) to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The results indicated the scaffold exerted high antibacterial activity. The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species (ROS) and direct contact action, respectively, which resulted in the damage of their structures and functions. Besides, nMgO significantly increased the compressive properties of the scaffold including strength and modulus, due to its excellent mechanical properties and uniform dispersion in the PHBV matrix. Moreover, the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold. The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation, as well as osteogenic differentiation. The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. Keywords: Nano magnesium oxide; antibacterial scaffolds; degradation properties; cytocompatibility; mechanical properties

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Section: Introductionmentioning

confidence: 99%

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Shuai

Guo

Gao

et al. 2024

IJB

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“…Clinically significant bacteria like methicillin resistant S. aureus (MRSA), vancomycin resistant enterococci and extended-spectrum β-lactamase (ESBL) producing E. coli are increasing rampantly [1,2]. Also, antibiotics sometimes cause side effects on the host like hypersensitivity, immune-suppression and allergic reactions [3]. This burning problem has generated the colossal need to investigate alternative sources of treatment with fewer side effects to combat the activities of these pathogens [4].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

Padalia¹,

Ch²

2015

Appli Micro Open Access

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Bacteria have evolved numerous defences against antimicrobial agent and drug resistance in pathogen is on rise. This is due to rapid development of multi-drug resistance, limited anti-bacterial spectrum and adverse effects of available anti-microbial agents. This necessitates the search for new antimicrobials with diverse structures and novel mechanism of action. Flowers are mostly used for ornamental purposes and they are not frequently worked out hence marigold flower was selected for the study. The antimicrobial activity of different solvent (Hexane, Toluene, Ethyl acetate, Acetone, Methanol and Aqueous) extracts of marigold flowers were evaluated by agar well diffusion method against a panel of pathogenic microorganisms. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of acetone extract and its fraction were evaluated. B. cereus and K. pneumonia were the most sensitive organisms to acetone extract and minimum inhibitory concentration (MIC) was 78 µg/ml. Synergistic effect of acetone extract and commercial antibiotics (chloroamphenicol and ceftazidime) against pathogenic bacteria was investigated. The best synergistic activity was with combination of acetone extract and ceftazidime against B. subtilis and P. aeruginosa with FIC indices 0.312 and 0.093 respectively. Only the polar solvent acetone extract showed promising antibacterial and synergistic activity. These results indicate that combination between plant extract and the antibiotics could be useful in fighting emerging drug-resistant microorganisms and choice of the solvent plays a prominent role in evaluating antimicrobial activity of medicinal plants. Flowers can be taken as an alternative source of antimicrobial agent against the human pathogens.

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“…This can further be investigated in a wide scale for the purpose of drug development against various deficiencies 24 . Antimicrobial activity: Among the four solvent extracts, maximum inhibition was observed in methanol extract (14-22mm) followed by aqueous (13-19mm), petroleum ether (11)(12)(13)(14)(15)(16)(17) and chloroform extracts (13-16mm) as shown in Fig. 1.…”

Section: Mineral Analysismentioning

confidence: 93%

“…The agar well diffusion method was followed to test different extracts of Pterocarpus marsupium bark for antimicrobial activity 17,18 .The bacterial isolates were grown in nutrient broth for 18 hour and standardized to 0.5 McFarland standards (106 CFU/ml). The fungal isolates grown on Potato dextrose agar (PDA) at 25°C until they are sporulated.…”

Section: Disc Diffusion Methodmentioning

confidence: 99%

Untitled

2017

IJPSR

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Pterocarpus marsupium Roxb. (Fabaceae) is a moderate to large deciduous tree, belonging to family Fabaceae. It is considered as an extremely useful source of unique natural products for development of medicines against various diseases and for industrial product development. The present study includes physicochemical parameters like ash value, extractive value, fluorescence analysis, moisture content and preliminary phytochemical screening along with mineral analysis. Antimicrobial activity was also assessed for this plant. The physicochemical constants obtained were within normal levels prescribed by standards. The phytochemical studies revealed the presence of primary and secondary metabolites in various solvent extracts of Pterocarpus marsupium bark. The estimated mineral composition was in good amounts which would serve as a device for deciding dosage of ayurvedic drug prepared from the plant. Antimicrobial activity by disc diffusion method indicated the zone of inhibition which ranges from 11-22mm for different extracts. Further evaluation of test samples for minimum inhibitory concentration (MIC) using micro dilution method showed that the methanol extract had exhibited significant activity by inhibiting S.typhi, E.faecalis at 12.5μg/ml and A.niger at 25μg/ml. The present paper will provide the data which is helpful in correct identification, standardization of this medicinal plant prior to carrying out further pharmacological evaluation and also help in preventing its adulteration.

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Phytochemical screening and in vitro antimicrobial activity of Typha angustifolia Linn leaves extract against pathogenic gram negative micro organisms

Cited by 26 publications

References 7 publications

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Antimicrobial Efficacy of Different Solvent Extracts of Tagetes erecta L. Flower, Alone and in Combination with Antibiotics

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