Phytochemical Screening and Isolation of New Ent-Clerodane Diterpenoids from Croton guatemalensis Lotsy

Escandón-Rivera, Sonia; Andrade‐Cetto, Adolfo; Rosas-Ramírez, Daniel; Arreguín-Espinosa, Roberto

doi:10.3390/plants11223159

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Regarding the phytochemical composition of ethanol–water extract, the presence of five ent -clerodane diterpenoids (junceic acid, crotoguatenoic acid A, crotoguatenoic acid B, formosin F, and bartsiifolic acid), and three flavonoids (rutin, epicatechin, and quercetin) was reported [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Espinoza-Hernández

Moreno-Vargas

Andrade‐Cetto

2023

Plants

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Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand the potential effects of the Croton genus on several diseases. It has been revealed that these terpenoid-rich species traditionally used to treat gastrointestinal diseases, heal wounds, and relieve pain have a wide range of therapeutic effects; however, those used to treat diabetes, as well as their action mechanisms, have not been reviewed so far. Therefore, the main objective of this review was to compile all Croton species that have shown pharmacological effects against diabetes and describe their action mechanisms. Through a search of the literature, 17 species with hypoglycemic, antihyperglycemic, antilipidemic, antihypertensive, antioxidant, and anti-inflammatory effects were found. Among the mechanisms by which they exerted these effects were the inhibition of α-glucosidases, the promotion of insulin secretion, and the increase in glucose uptake. Interestingly, it was found that some of them may have antihyperglycemic properties, although there were no ethnopharmacological reports that support their traditional use. Moreover, others only presented studies on their hypoglycemic effect in fasting, so further works are encouraged to describe the mechanisms involved in lowering fasting blood glucose levels, such as hepatic glucose production, especially for C. cajucara, C. cuneatus, C. gratissimus var. gratissimus, C. guatemalensis, and C. membranaceus. It is expected that this review contributes to the plant science knowledge of the genus, and it can be used in future references on the identification and development of new molecules/phytomedicines that help in the treatment of diabetes.

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Section: Resultsmentioning

confidence: 99%

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Espinoza-Hernández

Moreno-Vargas

Andrade‐Cetto

2023

Plants

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“…(6) insulated new composites 5,14-dihydroxyrotundone-9-(2)-methybut-(2)-enoate) and (-) 5,14-dihydroxyrotundane-9-benzoate from Croton hirtus using spectroscopic ways. Phytochemical webbing of an ethanol -water excerpt from the dinghy of Croton guatemalensis led to the insulation and identification of eight composites including five entclerodane diterpenoids (junceic acid (1), 6 (s)-acetoxy (16), 14-trien-20-oic acid(crotoguatenoic acid A (2), 6 (s)-hydroxyoxy (16), 14trien-20-oic acid(crotoguatenoic acid B (3), formosin F (4), bartsiifolic acid (5)), and three flavonoids(rutin (6), epicatechin (7), and quercetin ( 8)) [7] .…”

Section: Isolation Of Compounds From Croton Plantmentioning

confidence: 99%

Biological investigation and chemical constituents of Croton nigritanus scott elliot

Abdullahi,

Isyaka,

Suleiman

2024

J Pharmacogn Phytochem

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Croton nigritanus is a member of the Euphorbiaceae family, which has about 1,300 species worldwide and is found in tropical climates. Many of these species have a long history of use as medicines in South America, Asia, and Africa. They have been used to cure a variety of illnesses, including malaria, ulcers, diabetes, constipation, and cancer. In this study, it was determined what new molecular structures were present in the compounds taken from Croton nigritanus leaves from Kaduna, Nigeria. The procedure involves liquid-liquid extraction using n-hexane and dichloromethane as solvents through the partition method, followed by solid-liquid extraction utilizing the maceration method with dichloromethane as the solvent. Thin-layer chromatography and gravity column chromatography (GCC) were used for separation and purification. FTIR and 1HNMR spectroscopy were used to identify the isolated chemical. The present compound was effectively isolated and examined in the investigation. Furthermore, Croton nigritanus crude extract shown action against both Yeast and A. niger, indicating its potential for treating a variety of fungal illnesses that impact living things.

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ISOLATION OF SQUALENE FROM DICHLOROMssETHANE EXTRACT OF CROTON NIGRITANUS LEAF

Abdullahi,

Nkemakonam,

Garba

et al. 2024

FJS

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A precursor of steroids with a variety of biological activities is squalene. The purpose of the study was to identify and describe the industrial/medical chemical found in Croton nigritanus. Using the solvents such as; dichloromethane, ethyl acetate, and n-hexane, the procedure entails a liquid-liquid extraction stage using the partition method and a solid-liquid extraction step using the maceration method. For separation and purification, gravity column chromatography (GCC) and thin-layer chromatography were employed. The isolated chemical's identity was determined using FTIR, 1H NMR and GC-MS spectroscopy. The inquiry successfully extracted and analyzed the major chemical compound which was identified as Squalene.

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Phytochemical Screening and Isolation of New Ent-Clerodane Diterpenoids from Croton guatemalensis Lotsy

Cited by 4 publications

References 40 publications

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Croton Species: A Systematic Review

Biological investigation and chemical constituents of Croton nigritanus scott elliot

ISOLATION OF SQUALENE FROM DICHLOROMssETHANE EXTRACT OF CROTON NIGRITANUS LEAF

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