Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes

Abstract

Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes

Andrographis paniculata (Burm. f.) Wall. ex Nees: An Updated Review of Phytochemistry, Antimicrobial Pharmacology, and Clinical Safety and Efficacy

“…A. paniculata also influences mild to moderately active ulcerative patient. Administration of 1800 mg showed a significant clinical response (rectal bleeding) compared to placebo (p = 0.0183) [61].…”

“…These included 11 controlled clinical trials of the treatment of uncomplicated URTIs (eight studies) [56,[58][59][60][238][239][240]242], viral infections (three studies)influenza (two studies) [55,57] and HIV (1 studies) [54], and one trial focused on the immunity enhancement [241] that prevent the occurrence of the common cold in a rural school-going healthy student (Table 3). The remaining controlled clinical trials are 11 that covered the A. paniculata treatment on the healthy volunteers (three studies)-physiological effects [12], semen quality and fertility [243], pharmacokinetics [244], two studies each for ulcerative colitis [62,63], arthritis pain [66,245], and other studies include one trial each of Familial Mediterranean Fever (FMF) [246], hypertriglyceridemia [64], fatigue [67], type 2 diabetes mellitus [61].…”

“…Our systematic investigation did not reveal any clinical studies conducted from 2010 to now. However, several clinical studies conducted using A. paniculata extracts or pure compounds on the healthy volunteer to check semen quality [243], pharmacokinetics and tolerance ability [244], ulcerative colitis [62,63], arthritis [66,245], fatigue [67], Familial Mediterranean Fever [246], hypertriglyceridemia [64], and type 2 diabetes mellitus [61] (Supplementary Table S3).…”

“…The extracts reported having approximately 4-6% of andrographolide [56,60], responsible for the beneficial effects of the plant extracts. In recent years, there are few more clinical studies conducted [12,[61][62][63][64][65][66][67][68][69][70][71][72][73]. However, to date, Andrographolide or A. paniculata extracts have not achieved the human clinical trial stage.…”

Phytopharmacological Possibilities of Bird Cherry Prunus padus L. and Prunus serotina L. Species and Their Bioactive Phytochemicals

“…Natural products, mainly of plant origin, are gaining interest all over the world. Some of them are already used as a substitute or complementary to unconventional forms of drugs due to the toxicity and side effects of synthetic drugs [ 24 , 25 , 26 , 27 , 28 , 29 ].…”