Phytochemical Screening, Antimalarial, Antioxidant, Anti-inflammatory, and Antimicrobial Potential of Ananas comosus Extract

Kumar, G Vijay; Deep, Aakash; Kumar, Shashank; Nandal, Rimmy; Singh, Inderbir; Kaushik, Meenakshi; Hoti, S.L.; Rakesh, K. Marwaha; Arun, K.; Wadhwa, Deepak

doi:10.2174/2211352518999200429110222

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Additionally, the anti-inflammatory activity of the formulation at various concentrations (ranging from 10 to 50 µL) and diclofenac sodium was evaluated using this assay. The assay followed the methodology outlined by Kumar et al [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Antioxidant, Anti-inflammatory, and Antimicrobial Activity of the Kalanchoe pinnata and Piper longum Formulation Against Oral Pathogens

Anandan,

Shanmugam

2024

Cureus

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Background Dental caries stands out as a significant global infectious disease, with oral diseases posing substantial health concerns primarily due to bacterial, fungal, and yeast infections. Kalanchoe pinnata demonstrates antimicrobial, anticancer, antiparasitic, and hepatoprotective properties, with applications in various ailments. Piper longum exhibits potent antimicrobial effects against bacterial and viral pathogens due to the bioactive compounds within the plant. This study aims to assess the antimicrobial efficacy of P. longum and K. pinnata formulation against oral pathogens and evaluate its other biomedical potential. Methodology The agar well diffusion method was employed to assess the antimicrobial activity of the formulation containing P. longum and K. pinnata against oral pathogens. The protein leakage assay was employed to assess the ability of the prepared formulation to cause protein release from oral pathogens. The other biomedical potentials of the prepared formulation including cytotoxic effects, antioxidant, and anti-inflammatory properties were investigated using in vitro assays. Results The prepared P. longum and K. pinnata formulation demonstrated significant antimicrobial activity against tested oral pathogens, with inhibition zones observed for Staphylococcus aureus (32 mm), Streptococcus mutans (22 mm), and Candida albicans (12 mm). However, no inhibition was observed on Enterococcus faecalis at the highest concentration of 100 μL. Additionally, the formulation demonstrated significant antioxidant activity with percentages of 89.22%, 84.4%, and 86.93% in 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H 2 O 2 ), and ferric (Fe 3+ )-reducing antioxidant power assays, respectively, at the maximum concentration of 50 μL. Furthermore, the formulation exhibited potential anti-inflammatory activity, as evidenced by 79% inhibition in bovine serum albumin (BSA) denaturation assay and 77% inhibition in egg albumin (EA) denaturation assay at the highest concentration of 50 μL. Additionally, the formulation displayed low cytotoxic effects, even at the highest concentration of 80 μL. Conclusion K. pinnata and P. longum formulation demonstrated potential antimicrobial efficacy against oral pathogens and exhibited diverse therapeutic potentials. Thus, the developed formulation could be used as a potential alternative for pharmaceutical drugs against oral pathogens.

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Section: Methodsmentioning

confidence: 99%

Antioxidant, Anti-inflammatory, and Antimicrobial Activity of the Kalanchoe pinnata and Piper longum Formulation Against Oral Pathogens

Anandan,

Shanmugam

2024

Cureus

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“…Various scientific studies reported that those ingredients in ALLURA™ possess antioxidant and anti-inflammatory activities. [3][4][5][6][7][8] Although the individual ingredient used in making ALLURA™ have been proven to possess therapeutic properties, the present study need to be conducted to validate the traditional claims, to justify its possible effectiveness thus supporting the scientifically validated knowledge of ALLURA™ ingredients.…”

Section: Introductionmentioning

confidence: 98%

In vitro and In vivo Assessments on Nutraceutical and Safety of Herb-Fruit Based Drink on Female Wistar Rats

Hamid

Zakaria

Majid

et al. 2023

imjm

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INTRODUCTION: The study aimed to assess the safety and nutraceutical properties of ALLURATM related to women’s health and skin beautification. MATERIALS AND METHODS: Determinations of total phenolic (TPC) and flavonoid contents (TFC) were done using the colorimetric method, followed by the identification of gallic acid via highperformance liquid chromatography (HPLC). Antioxidant activity was analyzed using 2,2 -diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radicals while its anti-inflammatory activity was measured using enzymelinked immunosorbent assay (ELISA). Anti-aging and whitening effects were determined by porcine elastase and mushroom tyrosinase activities, respectively. Skin cell growth promotion and rejuvenation were evaluated using in vitro scratch assay. Cytotoxicity assay was done using HSF1184 and 3T3 BALB/c cell lines. While, acute toxicity test was done on two groups (control and treatment) of six Wistar rats each. The nutraceutical properties were evaluated based on proximate analysis. RESULTS: ALLURATM exhibited DPPH-IC50 values of 180.40 µg/mL and ABTS-IC50 value of 174.40 µg/mL. TPC and TFC were 67.31 mg GAE/g extract and 43.21 mg CE/g extract, respectively while 10.98 mg/g of gallic acid were quantified. ALLURATM reduced pro-inflammatory cytokines of TNF-α and IL-6 and showed anti-aging (IC50-162.40 µg/mL) and whitening effects (IC50- 167.70 µg/mL). ALLURA™ also increased the proliferation of HSF1184 (≤ 1000 µg/ mL), producing significant secretion of epidermal growth factor (EGF) and shown to be non-cytotoxic. No mortality was observed at the highest dose of 2000 mg/kg b.w.t. nor the behavioral and morphological changes in rats. The proximate analysis resulted in high content of moisture and low calories. CONCLUSION: These findings provided preliminary reports for the first time on the functionality of ALLURA™ for its anti-inflammatory, antioxidant, and nutraceutical properties.

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“…antimalarial [8],anti-inflammatory [9], antidiabetic [10], anti-oxidant [11], anticancer [12] activities among others.This means that pineapple could be a valuable source of important bioactive compounds that have countlessbeneficial for therapeutic application.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical constituents and proximate analysis of dry pineapple peels

Owoeye

Akinlabu

Ajayi

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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The pineapple and its skin contain a lot of vitamin C, which helps to prevent and fight illnesses. Dry pineapple peel phytochemicals and proximate analysis were investigated in this study. Oil derived from ripe pineapple peels was tested for phytochemical constituents and proximate analysis of dry peel pineapple using a conventional method.Moisture content was 5.10±0.07%, the ash content was 3.78±0.05%, the fat content was 5.57±0.08%, the protein content was 5.78±0.10%, the crude fiber content was 4.10±0.06%, and the carbohydrate content was 75.68±0.86%. Alkaloid phenol, tannin, flavonoid, and saponin were identified as phytochemical components from the result of phytochemical screening.The presence of secondary metabolites in pineapple peel oil is a positive indicator that if thoroughly investigated, bioactive chemicals with significant biological activity may be extracted. As a result, it's plausible to believe that nutraceutical advantages can be derived from this waste (pineapple peel), potentially boosting humanity's prosperity, health and well-being.

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Phytochemical Screening, Antimalarial, Antioxidant, Anti-inflammatory, and Antimicrobial Potential of Ananas comosus Extract

Cited by 3 publications

References 8 publications

Antioxidant, Anti-inflammatory, and Antimicrobial Activity of the Kalanchoe pinnata and Piper longum Formulation Against Oral Pathogens

Antioxidant, Anti-inflammatory, and Antimicrobial Activity of the Kalanchoe pinnata and Piper longum Formulation Against Oral Pathogens

In vitro and In vivo Assessments on Nutraceutical and Safety of Herb-Fruit Based Drink on Female Wistar Rats

Phytochemical constituents and proximate analysis of dry pineapple peels

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