Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

Lima, Gabrielle Mendes; Quintans‐Júnior, Lucindo José; Thomazzi, Sara Maria; Almeida, Emyle Mayra Santana Alves; Melo, Mônica Santos de Souza; Serafini, Mairim Russo; Cavalcanti, Sócrates Cabral de Holanda; Gelain, Daniel Pens; Santos, João Paulo Almeida dos; Blank, Arie Fitzgerald; Alves, Péricles Barreto; Neta, Paulina Marques de Oliveira; Lima, Julianeli Tolentino de; Rocha, Ricardo Fagundes da; Moreira, José Cláudio Fonseca; Araújo, Adriano Antunes de Souza

doi:10.1590/s0102-695x2012005000002

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…beta eudesmol were identified. Similar findings were reported earlier in the essential oil of C. zizanioides (10)(11)(12). But the methodology followed in this study is simpler and cheaper than other distillation methods followed (13).…”

Section: Discussionsupporting

confidence: 89%

GC-MS analysis and in silico activity prediction of phytocompounds in the roots of Chrysopogon zizanioides (L.) Roberty

Shanti

Neerakkal

2021

Plant Sci. Today

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Chrysopogon zizanioides (L.) Roberty (Poaceae) commonly known as Ramachamis an aromatic, vigorous growing perennial grass with medicinal properties. The plant is tolerant to extreme soil and climatic conditions and is known for its cooling properties. Roots of the plant are widely used as body scrubber and is suggested for skin diseases in Ayurveda. The present work aims to identify the components in the crude methanolic root extract of C. zizanioides using GC-MS and also to predict the pharmacokinetic behaviour of selected compounds in silico using Swiss ADME online server . 41 compounds were identified of which sesquiterpenes formed the major group. Sesquiterpene Vetivenic acid was the compound with a maximum peak area of 38.9%. Components identified is reported to possess a range of biological activities like anti oxidant, antibacterial, anti cancer, anti inflammatory, anti ulcer, analgesic and insecticidal activities. Compounds with higher peak area like Vetivenic acid, beta vatirenene, beta.-Cedren-9-.alpha.-ol, D Viridiflorol, Gamma muurolene, (Z,E)-alpha-farnesene, Nootkatone, Aromadendrene oxide-(2), 7-Acetyl-2-hydroxy-2methyl-5isopropylbicyclo[4.3.0] nonane, Rosifoliol, 9,10-dehydro isolongifolene, Ylangenol, 4,7,10,13,16,19-Docosahexaenoic acid methyl ester, Carbonic acid, propargyl 2,2,2-tri chloroethyl ester, Oxacyclotetradeca-4,11-diyne, beta eudesmol and longifolene were evaluated in silico. All these compounds proved to obey Lipinski's rule-of-five and were water soluble. Vetivenic acid showed a good bioavailability score of 85% while the others showed 55%. None of the compounds were substrates to P glycoprotein. The values predicted may be used for preliminary evaluation of pharmacological properties of C. zizanioides and also as monographs for the development of potential semisynthetic or synthetic drugs.

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Section: Discussionsupporting

confidence: 89%

GC-MS analysis and in silico activity prediction of phytocompounds in the roots of Chrysopogon zizanioides (L.) Roberty

Shanti

Neerakkal

2021

Plant Sci. Today

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“…According to Lima and colleagues [28], an excellent indicator of anti-inflammatory activity of new compounds is the peritoneal cell migration inhibition in acute inflammation models. In the present study, it was verified that F2.0v polysaccharide is be able to inhibit the migration of leukocytes into the mice peritoneal cavity after stimulation with peptone in all tested concentrations (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

et al. 2013

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Fucan is a term that defines a family of homo- and hetero-polysaccharides containing sulfated l-fucose in its structure. In this work, a heterofucan (F2.0v) from the seaweed, Dictyota menstrualis, was evaluated as an antinociceptive and anti-inflammatory agent. F2.0v (20.0 mg/kg) inhibits 100% of leukocyte migration into the peritoneal cavity after chemical stimulation. However, F2.0v does not alter the expression of interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), as well as tumor necrosis factor alpha (TNF-α). F2.0v (20.0 mg/kg) has peripheral antinociceptive activity with potency similar to dipyrone. On the other hand, it had no effect on pain response on the hot plate test. Confocal microscopy analysis and flow cytometry showed that F2.0v binds to the surface of leucocytes, which leads us to suggest that the mechanism of action of anti-inflammatory and antinociceptive F2.0v is related to its ability to inhibit the migration of leukocytes to the site of tissue injury. In summary, the data show that F2.0v compound has great potential as an antinociceptive and anti-inflammatory, and future studies will be performed to further characterize the mechanism of action of F2.0v.

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“…It also reduced the number of writhings in a dose-dependent manner but did not display activity on thermal hyperalgesia ( Lee et al, 2019 ). In the study by Lima et al (2012) the EO of Chrysopogon zizanioides L (Roberty, Poaceae) produced antinociception similar to morphine in the acetic acid test, and this effect was partially reversed by naloxone. Moreover, it reduced the licking time in the second phase of the formalin test, but it did not demonstrate any effects in the Hargreaves’ test.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of the two items regarding selection bias, no study reported the method of allocation and, even though they conducted baseline measures, none of the studies describe how experimental groups were composed to ensure homogeneity and consistency. Only the study by Lima and collaborators (Lima et al, 2012) in which mice with baseline latencies of more than 10 s, and studies by de Oliveira Júnior and colleagues (de Oliveira Júnior et al, 2017;de Oliveira et al, 2018) of more than 20 s, at the hot-plate were excluded from the experiments.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…As reported in Table 1, five studies (Guimaraes et al, 2009;Andrade et al, 2012;Lima et al, 2012;de Oliveira Júnior et al, 2017;de Oliveira et al, 2018) adopted random housing of mice. The paper by Khodabakhsh et al reported no randomization of mice but only of rats, which are not included in this systematic review and meta-analysis (Khodabakhsh et al, 2015).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

et al. 2021

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Background: The demand for essential oils (EOs) has been steadily growing over the years. This is mirrored by a substantial increase in research concerned with EOs also in the field of inflammatory and neuropathic pain. The purpose of this present systematic review and meta-analysis is to investigate the preclinical evidence in favor of the working hypothesis of the analgesic properties of EOs, elucidating whether there is a consistent rational basis for translation into clinical settings.Methods: A literature search has been conducted on databases relevant for medical scientific literature, i.e., PubMed/MEDLINE, Scopus, and Web of Science from database inception until November 2, 2020, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) criteria for systematic reviews and meta-analyses.Results: The search was conducted in order to answer the following PICOS (participants/population, interventions, comparisons, outcomes, and study design) question: are EOs efficacious in reducing acute nociceptive pain and/or neuropathic pain in mice experimental models? The search retrieved 2,491 records, leaving 954 studies to screen after the removal of duplicates. The title and abstract of all 954 studies were screened, which left 127 records to evaluate in full text. Of these, 30 articles were eligible for inclusion.Conclusion: Most studies (27) assessed the analgesic properties of EOs on acute nociceptive pain models, e.g. the acetic acid writhings test, the formalin test, and the hot plate test. Unfortunately, efficacy in neuropathic pain models, which are a more suitable model for human conditions of chronic pain, had fewer results (only three studies). Moreover, some methodologies raised concerns in terms of the risk of bias. Therefore, EOs with proven efficacy in both types of pain were corroborated by methodologically consistent studies, like the EO of bergamot, which should be studied in clinical trials to enhance the translational impact of preclinical modeling on clinical pain research.

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Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

Cited by 10 publications

References 21 publications

GC-MS analysis and in silico activity prediction of phytocompounds in the roots of Chrysopogon zizanioides (L.) Roberty

GC-MS analysis and in silico activity prediction of phytocompounds in the roots of Chrysopogon zizanioides (L.) Roberty

Evaluation of Anti-Nociceptive and Anti-Inflammatory Activities of a Heterofucan from Dictyota menstrualis

Efficacy of Essential Oils in Pain: A Systematic Review and Meta-Analysis of Preclinical Evidence

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