Phytochemical screening, biological evaluation, and molecular docking studies of aerial parts of Trigonella hamosa (branched Fenugreek)

Rao, Huma; Ahmad, Saeed; Aati, Hanan Y.; Basit, Abdul; Ahmad, Imtiaz; Ghalloo, Bilal Ahmad; Shehzad, Muhammad Nadeem; Nazar, Rahat; Zeeshan, Muhammad; Nasim, Jawad; Khan, Kashif ur Rehman

doi:10.1016/j.arabjc.2023.104795

Arabian Journal of Chemistry

2023

DOI: 10.1016/j.arabjc.2023.104795

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Phytochemical screening, biological evaluation, and molecular docking studies of aerial parts of Trigonella hamosa (branched Fenugreek)

Huma Rao

Saeed Ahmad

Hanan Y. Aati

et al.

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2024

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Cited by 8 publications

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Exploring Phytochemical Profile and Biological Activities of Callistemon viminalis (Sol. ex Gaertn.) G.Don ex Loudon) By In vitro and In silico Approaches

Kanwal,

Ahmad,

Rao

et al. 2024

Chemistry & Biodiversity

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Callistemon viminalis (Sol. ex Gaertn.) G. Don ex Loudon) (Family: Myrtaceae) is used for its medicinal properties in treating various metabolic disorders. We investigated the chemical characterization and biological screening of n‐hexane extract of C. viminalis. Total phenolic content was (37.45 ± 7.40 mg GA.E/g D.E ± S.D) and total flavonoid content was (18.43 ± 6.34 mg R.E/g D.E ± S.D). The GC‐MS screening of n‐hexane extract tentatively identified 70 bioactive phytochemicals. The maximum antioxidant potential (289.99 ± 9.01 mg T.E/g D.E±S.D) was observed by FRAP assay. The enzyme inhibition assays revealed α‐glucosidase and α‐amylase inhibition (6.9 ± 0.13 and 7.2 ± 0.56 mmol of ACA.E/g D.E±S.D), urease (4.95 ± 0.9 mg of TU.E/g D.E±S.D), acetylcholinesterase (2.9 ± 0.08 mg GALA.E/g D.E±S.D), lipoxygenase (4.93 ± 1.05 mg of Indo.E/g D.E±S.D) and tyrosinase (4.33 ± 0.62 mg of KA.E/g D.E±S.D) inhibition. The extract showed antibacterial potential against Salmonella typhi (53.90±5.05) Bacillus subtilis (68.55±2.70%), Salmonella aureus (71.30±4.44%) and Pseudomonas aeruginosa (57.86±6.02%). The docking studies revealed a good docking interaction of ligands against the studied enzymes while ADME analysis revelaed pharmacokinetic profile of the phytoconstituents. C. viminalis possesses promising therapeutic potential and can be further explored for drug development and drug designing.

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Exploring Phytochemical Profile and Biological Activities of Callistemon viminalis (Sol. ex Gaertn.) G.Don ex Loudon) By In vitro and In silico Approaches

Kanwal,

Ahmad,

Rao

et al. 2024

Chemistry & Biodiversity

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Evaluation of the antifungal properties of nanoliposomes containing rhinacanthin-C isolated from the leaves of Rhinacanthus nasutus

Paosupap,

Basit,

Sajomsang

et al. 2024

World J Microbiol Biotechnol

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Novel insights into the anti-asthmatic effect of Raphanus sativus L. (Raphani Semen): Targeting immune cells, inflammatory pathways and oxidative stress markers

Gul,

Hussain,

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Phytochemical screening, biological evaluation, and molecular docking studies of aerial parts of Trigonella hamosa (branched Fenugreek)

Cited by 8 publications

References 57 publications

Exploring Phytochemical Profile and Biological Activities of Callistemon viminalis (Sol. ex Gaertn.) G.Don ex Loudon) By In vitro and In silico Approaches

Exploring Phytochemical Profile and Biological Activities of Callistemon viminalis (Sol. ex Gaertn.) G.Don ex Loudon) By In vitro and In silico Approaches

Evaluation of the antifungal properties of nanoliposomes containing rhinacanthin-C isolated from the leaves of Rhinacanthus nasutus

Novel insights into the anti-asthmatic effect of Raphanus sativus L. (Raphani Semen): Targeting immune cells, inflammatory pathways and oxidative stress markers

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