Phytochemical studies and antibacterial activity of the aerial parts of Physospermum verticillatum

Boulacel, Ibtissem; Djarri, Lakhdar; Azzouzi, Salima; Medjroubi, Kamel; Demirtaş, İbrahim; Laouer, Hocine; Akkal, Salah

doi:10.3329/bjp.v12i2.29668

Bangladesh J Pharmacol

2017

DOI: 10.3329/bjp.v12i2.29668

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Phytochemical studies and antibacterial activity of the aerial parts of Physospermum verticillatum

Ibtissem Boulacel

Lakhdar Djarri

Salima Azzouzi³

et al.

Abstract: In this study, we focused on the isolation and identification of the main compounds, triterpene, sterol, phenolic and fatty acid from the aerial parts of Physospermum verticillatum, which has not been previously reported. Dichloromethane, ethyl acetate and n-butanol extracts led to the isolation of ß-amyrin (1), 3,11-dihydroxy-12-oleanene (2), pentadecanoic acid (3), spina-sterol (4), spinasterol-3-O-ß-D-glucopyranoside (5) and saikochromic acid (6). These compounds were determined by means of the combined sys… Show more

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Cited by 2 publications

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Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells

Vrchotová,

Doudová,

Bednář

et al. 2024

Chem. Pap.

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The roots of Impatiens glandulifera belong to plants, or part of plants with a high content of α-spinasterol. Chromatographic analysis of roots hexane extract using GC–MS revealed that α-spinasterol is the dominant substance in the freeze-dried roots of Impatiens glandulifera and its content reaches ca. 1 wt%. When the hexane extracts are concentrated, α-spinasterol crystals fall out in the form of tiny needles, so the isolation of this substance from the roots of Impatiens glandulifera is very easy. Regarding the easy isolation and usage of phytosterols as anticancer and antimicrobial agents, cytotoxicity tests were performed using hepatic Hep G2 cells and blood HL-60 cells. Since hexane is an organic solvent, the cytotoxicity of the used hexane concentrations was measured, too. Graphical abstract

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Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells

Vrchotová,

Doudová,

Bednář

et al. 2024

Chem. Pap.

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Antibacterial, Antioxidant, and Angiotensin-I Converting Enzyme Inhibition Effects of Margotia gummifera Extracts Rich in Phenolic Compounds

Bouchekrit

Laouer

Cakmak

et al. 2022

CBC

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Objective: The current investigation was conducted to evaluate phenol and flavonoid contents, antibacterial, antioxidant and antihypertensive potentials of three extracts of Margotia gummifera aerial parts. Methods: The antibacterial effect was assessed using wells agar diffusion method against 11 strains. The antioxidant effect was evaluated using different methods, 2, 2-diphenyl-1-picrylhydrazyl, total antioxidant capacity, ferric reducing ability power, cupric reducing antioxidant capacity and β-carotene/linoleic acid bleaching assay. The antihypertensive activity was performed using hippuryl-histidyl-leucine substrates. Results: The highest yield was obtained by hydro-methanolic extract, 19.801 %, however ethyl acetate extract seemed to be rich on phenolic and flavonoid compounds comparing to other extracts, 822.14±69.10 mg GAE g-1 ext. and 117.28±1.80 mg RE g-1 ext., respectively. The high free radical scavenging activity was mentioned in ethyl acetate extract with IC50 of 48.820±1.25 µg/ml. The same extract showed better antioxidant activity in all tested procedures. In antibacterial activity, the hydro-methanolic extract exhibited moderate effect against all tested bacteria except Salmonella enterica and Enterococcus faecalis which gave 18±2.0 and 16±1.0 mm of inhibition, whereas, it seemed to be inactive towards two Gram-negative bacteria. Concerning antihypertensive activity, all extracts can inhibit the Angiotensin-I Converting Enzyme, but the potential effect was given by hydro-methanolic and aqueous extracts, 97.75 % and 96.65 %, respectively. Conclusion: It can be stated that bioactive compounds of Margotia gummifera extracts had different biological activities which confirm their therapeutic uses in traditional medicine.

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Phytochemical studies and antibacterial activity of the aerial parts of Physospermum verticillatum

Cited by 2 publications

References 3 publications

Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells

Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells

Antibacterial, Antioxidant, and Angiotensin-I Converting Enzyme Inhibition Effects of Margotia gummifera Extracts Rich in Phenolic Compounds

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