Phytochemical, toxicological and antimicrobial evaluation of lawsonia inermis extracts against clinical isolates of pathogenic bacteria

Gull, Iram; Sohail, Maria; Aslam, Muhammad Shahbaz; Athar, Makshoof

doi:10.1186/1476-0711-12-36

Cited by 39 publications

(44 citation statements)

References 14 publications

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“…(Lawaly et al, 2017). The results of this study is in accordance with previous reports suggesting potent antibacterial activity of A. nilotica (Ali et al, 2017;Singh and Thakur, 2016;Gupta, 2015;Raghavendra et al, 2006), L. inermis Gull et al, 2013;Musa et al, 2011;Akter et al, 2010;Babu and Subhasree, 2009;Al-Rubiay et al, 2008;Nayak et al, 2007) and Z. jujube Linn (Elaloui et al, 2017;Arifa et al, 2016;Naz et al, 2013) against both gram negative and gram positive bacteria.…”

Section: Discussionsupporting

confidence: 93%

“…The result of this study conforms to earlier reports suggesting the presence of flavonoids, tannins, saponins, glycosides, steroids, terpenes and phenols in methanolic leaves extract on A. nilotica (Lawaly et al, 2017;Mrityunjoy et al, 2016;Singh and Thakur, 2016;Raghavendra et al, 2006), L. inermis (Rao et al, 2016;Gull et al, 2013;Nayak et al, 2007) and Z. jujube Linn (Elaloui et al , 2017;Mahajan and Chopda, 2009). In contrast, only Z. jujube Linn possessed volatile oils as reported by Kundu et al (1989).…”

Section: Discussionsupporting

confidence: 91%

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Antimicrobial Activities of Acacia nilotica, Ziziphus Jujube Linn and Lawsonia Inermis

Abubakar¹,

Dandare²,

Wasagu³

et al. 2018

Nig. J. Basic Appl. Sci.

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Infectious diseases are important cause of morbidity and mortality due to continuous emergence of microbial resistance to conventional drugs. Acacia nilotica, Ziziphus jujube Linn and Lawsonia inermis are widely used for traditional medicine in Northern Nigeria. However, little is known about the biochemical and microbiological potentials of these indigenous plants. In this study, the plants leaves were screened for phytochemical and in vitro antimicrobial potentials using standard methods. Quantitative phytochemical analysis of crude methanolic leave extracts revealed high content of glycoside, tannins and phenols. High levels of saponins and flavonoids were also detected. The extracts exhibited antibacterial effects on Escherichia coli, Pseudomonas flourecense, Streptococcus and Staphylococcus aureus. At 50 mg/ml extract concentration, the zone of inhibition observed was greater than 6mm. This indicates high inhibitory potency of the plants leaves. In comparison to streptomycin sulphate, A. nilotica and L. inermis had statistically similar (P>0.05) effect on E. coli at 50 mg/ml. In general, the inhibitory effect of A. nilotica and L. inermis were higher than that of Z. jujube Linn in all concentrations, except on E. coli at 150 mg/ml. Both the extracts and control drug had minimum inhibitory concentration of 10 mg/ml for all the microbes tested except Streptococcus (20-25 mg/ml). Furthermore, the average Minimum Bactericidal Concentration was 15 mg/ml except for Streptococcus with 20-25 mg/ml. Methanol extracts of Acacia nilotica, Ziziphus jujube Linn, and Lawsonia inermis exhibit antibacterial effect, hence could be used as sources of potent agents against bacterial infection.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Antimicrobial Activities of Acacia nilotica, Ziziphus Jujube Linn and Lawsonia Inermis

Abubakar¹,

Dandare²,

Wasagu³

et al. 2018

Nig. J. Basic Appl. Sci.

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“…Many studies on Lawsonia inermis leaves extractions showed that it had antibacterial activity against Gram [8][9][10]; and antifungal activity aganist (Candida albicans, Cryptococcus neoformans, A. niger and F. oxysporum) [11].…”

Section: Introductionmentioning

confidence: 99%

Natural Antimicrobial Activity of Lawsonia Inermis and Indigo Tinctoria Against Clinically Isolated Microorganisms

Rimawi

Masri

Husein

et al. 2018

Int J Pharm Pharm Sci

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Objective: The present study aimed at evaluating the natural antimicrobial activity of Lawsonia inermis (L. inermis) and Indigofera tinctoria (I. tinctoria) against a reference and pathogenic clinically isolated strains compare with some antibiotics. Methods:The antimicrobial activity of Lawsonia inermis (red henna) and Indigo tinctoria (black henna) was evaluated against clinically isolated strains from urinary tract and wounds infected patients. The six tested strains namely were Staphylococcus aureus, Enterococcus fecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Candida albicans. The antimicrobial activity was evaluated by agar diffusion method and microplate dilution for measuring the minimum inhibitory concentration (MIC). An American Type Culture Collection (ATCC) of bacteria was used as a control for confirming the type of the isolated bacteria.Results: Both red and black henna showed variable antimicrobial activity against tested bacteria and C. albicans. Alcoholic and oily extracts were more effective than water. Staphylococcus epidermis was significantly affected with water extract of black henna (20±1.1) and red henna (11±0.5). Nigella sativa oil extract with black henna had showed significant synergism effects against some microorganisms as Enterococcus fecalis (40±1.5), P. aeruginosa (15±0.9) and Candida albicans (18±0.6). Conclusion:Black and red henna had antibacterial and antifungal activities. They exhibited synergistic effects when mixed with black seed oil.

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“…or death in first 2 hours and then after 24 hours. No sign of toxidrome were observed during in vivo toxicity evaluation in mice at 300 mg/kg concentration 36 .…”

Section: Miscellaneousmentioning

confidence: 90%

“…The minimum value of MIC for different bacterial strains ranged from 2.31 mg/ml to 9.27 mg/ml. At 1x MIC of each bacterial isolate, 3log 10 decrease in CFU was recorded after 6 hours of drug exposure and no growth was observed in almost all tested bacteria after 24 hours of exposure 36 .…”

Section: Analgesic and Antipyretic Activitymentioning

confidence: 93%

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2018

IJPSR

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Herbal medicines are in great demand in the developed as well as developing countries for primary healthcare because of their wide biological and medicinal activities, higher safety margins and lesser costs. Lawsonia inermis L. is commonly known as Henna or Mhendi and abundantly available in tropical and subtropical areas. Henna belongs to lythraceae, also known as the loosestrife family. Ancient history of India describes its diverse uses and also plays appreciable role in Ayurvedic or natural herbal medicines. Henna has been used cosmetically and medicinally for over 9,000 years. Currently, there is a renewed interest in henna due the wide range of its pharmacological activities, safety and availability. The present attempt is to review and compile updated information on various aspects of Lawsonia inermis (Linn), a plant used all over the world. It gives a complete view of its pharmacological actions such as analgesic, anti-

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Phytochemical, toxicological and antimicrobial evaluation of lawsonia inermis extracts against clinical isolates of pathogenic bacteria

Cited by 39 publications

References 14 publications

Antimicrobial Activities of Acacia nilotica, Ziziphus Jujube Linn and Lawsonia Inermis

Antimicrobial Activities of Acacia nilotica, Ziziphus Jujube Linn and Lawsonia Inermis

Natural Antimicrobial Activity of Lawsonia Inermis and Indigo Tinctoria Against Clinically Isolated Microorganisms

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