Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?

Szic, Katarzyna Szarc vel; Palagani, Ajay; Hassannia, Behrouz; Sabbe, Linde; Heyninck, Karen; Haegeman, Guy; Berghe, Wim Vanden

doi:10.5772/28499

Cited by 6 publications

(4 citation statements)

References 326 publications

(455 reference statements)

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“…Targeting these proteins in addition to various kinases (e.g. mitogen-activated protein kinases (MAPKs), phosphatidylinositide-3-kinase (PI3K), protein kinase B isozymes (AKT), Aurora B, Polo-like kinase 1 (PLK1)), poly(ADP-ribose) polymerase (PARP) and other epigenome modifying enzymes KDMs (LSD1, JMJD3) and HATs (p300/CBP (CREB binding protein) coactivators) [30] make them extremely powerful modifiers of cellular processes included in all aspects of cellular survival and cellular death. Besides, for all these multilevel ways of acting, affecting a large number of biochemical signaling pathways, natural polyphenols are excellent examples of polypharmacological compounds.…”

Section: Interplay Between Dna Methylation and Histone Acetylationmentioning

confidence: 99%

Epigenome, Cancer Prevention and Flavonoids and Curcumin

Stepanić¹,

Kujundžić²,

Trošelj³

2014

Epigenetics and Epigenomics

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Section: Interplay Between Dna Methylation and Histone Acetylationmentioning

confidence: 99%

Epigenome, Cancer Prevention and Flavonoids and Curcumin

Stepanić¹,

Kujundžić²,

Trošelj³

2014

Epigenetics and Epigenomics

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“…Cancer is a significant health concern. One in eight deaths worldwide is due to cancer [ 1 ]. It represents the first or second cause of death in advanced countries.…”

Section: Introductionmentioning

confidence: 99%

Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on CarcinogenesisIn VitroandIn Vivo

Tan

Norhaizan

2017

BioMed Research International

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Cancer is a significant global health concern affecting men and women worldwide. Although current chemopreventive drugs could inhibit the growth of cancer cells, they exert many adverse side effects. Dietary factor plays a crucial role in the management of cancers and has drawn the attention of researchers to be used as an option to combat this disease. Both in vitro and in vivo studies showed that rice and its by-products display encouraging results in the prevention of this disease. The mechanism of anticancer effect is suggested partly through potentiation of bioactive compounds like vitamin E, phytic acid, γ-aminobutyric acid (GABA), γ-oryzanol, and phenolics. Nevertheless, the bioactivity of rice and its by-products is still incompletely understood. In this review, we present the findings from a preclinical study both in in vitro and in animal experiments on the promising role of rice by-products with focus on cancer prevention.

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“…Despite extensive attempts and the availability of multiple chemotherapeutic agents, their efficacies are still limited because of heterogeneity in cancer cells, emergences of drug-resistant populations of cells and complicated tumor interactions [ 2 ]. Natural compounds with medicinal properties have drawn interest as chemotherapeutics due to their ability to target various cancer growth mechanisms, including cell proliferation and resistance to death, replicative immortality, invasion and metastasis, angiogenesis and inflammation that promotes tumors [ 3 ]. Several anticancer targets have been studied, but in recent times, the selection of targets based on the role of proteins in the initiation and development of cancer has been considered critical, which makes epigenetic proteins very important therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A

et al. 2023

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Cancer is characterized by the abnormal development of cells that divide in an uncontrolled manner and further take over the body and destroy the normal cells of the body. Although several therapies are practiced, the demand and need for new therapeutic agents are ever-increasing because of issues with the safety, efficacy and efficiency of old drugs. Several plant-based therapeutics are being used for treatment, either as conjugates with existing drugs or as standalone formulations. Withania somnifera (L.) Dunal is a highly studied medicinal plant which is known to possess immunomodulatory activity as well as anticancer properties. The pivotal role of KAT6A in major cellular pathways and its oncogenic nature make it an important target in cancer treatment. Based on the literature and curated datasets, twenty-six compounds from the root of W. somnifera and a standard inhibitor were docked with the target KAT6A using Autodock vina. The compounds and the inhibitor complexes were subjected to molecular dynamics simulation (50 ns) using Desmond to understand the stability and interactions. The top compounds (based on the docking score of less than −8.5 kcal/mol) were evaluated in comparison to the inhibitor. Based on interactions at ARG655, LEU686, GLN760, ARG660, LEU689 and LYS763 amino acids with the inhibitor WM-8014, the compounds from W. somnifera were evaluated. Withanolide D, Withasomniferol C, Withanolide E, 27-Hydroxywithanone, Withanolide G, Withasomniferol B and Sitoindoside IX showed high stability with the residues of interest. The cell viability of human breast cancer MCF-7 cells was evaluated by treating them with W. Somnifera root extract using an MTT assay, which showed inhibitory activity with an IC50 value of 45 µg/mL. The data from the study support the traditional practice of W. somnifera as an anticancer herb.

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Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?

Cited by 6 publications

References 326 publications

Epigenome, Cancer Prevention and Flavonoids and Curcumin

Epigenome, Cancer Prevention and Flavonoids and Curcumin

Scientific Evidence of Rice By-Products for Cancer Prevention: Chemopreventive Properties of Waste Products from Rice Milling on CarcinogenesisIn VitroandIn Vivo

In Silico Study on the Interactions, Molecular Docking, Dynamics and Simulation of Potential Compounds from Withania somnifera (L.) Dunal Root against Cancer by Targeting KAT6A

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