Phytochemicals and Health Benefits of Dried Apricots

Göncüoğlu, Neslihan; Mogol, Burçe Ataç; Gökmen, Vural

doi:10.1002/9781118464663.ch12

Cited by 5 publications

(4 citation statements)

References 51 publications

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“…The enzymatic oxidation is followed by non-enzymatic polymerization of the resulted quinones into dark/brown polymers called melanins [43]. Apricot PPO remains active at drying temperature below 55 °C [44], and since TSD was performed at temperatures ~ 40 ° C, enzymatic browning is mostly the main cause of phenolic compounds decrease in TSD apricots. This was also visually confirmed, where the dried apricots had dark colors.…”

Section: Discussionmentioning

confidence: 99%

Effect of traditional sun-drying and oven-drying on carotenoids and phenolic compounds of apricot (Prunus armeniaca L.)

Derardja¹,

Barkat²

2019

Nor. Afr. J. Food Nutr. Res.

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Background: The indubitable role of phytochemicals such as carotenoids and phenolic compounds in human health has prompted the researchers to study the factors affecting the stability and the availability of these compounds. Aims: This study investigates the effect of two drying processes; oven-drying (OD) and traditional sun-drying (TSD) on carotenoids and phenolic compounds of apricots. Material and Methods: OD was performed at 65°C, and TSD was performed by direct exposure of apricot to sunlight at daytime temperatures around 40°C and relative humidity between 25 and 35%, following an Algerian traditional method of drying. Carotenoids and phenolic compounds were extracted, and then total carotenoids (TC), total phenolic compounds (TPC), total flavonoids (TF) and total tannins (TT) were spectrophotometrically quantified. The free radical scavenging activity (FRSA) of the phenolic extracts was measured by the DPPH method. Results: Carotenoids and phenolic compounds were significantly affected by both drying methods. OD decreased TC and TT by 44% and 12%, respectively, and increased TPC and TF by 4%. TDS affected negatively all the measured components, where TC, TPC, TF, and TT decreased by 67%, 15%, 43%, and 36%, respectively. However, the highest FRSA was reported for the TSD apricots (40%) followed by OD apricots (36%), and fresh apricots (32%). Conclusions: The effect of drying on apricot antioxidants depends on the applied drying method and the studied component. The direct sunlight exposure and the duration of drying condemned TSD to be more harmful on carotenoids and phenolic compounds compared to OD, where carotenoids where more fragile during TSD. In addition, OD improved the content of phenolic compounds by improving their extractability. However, TSD apricots seem to be a better source of free radical scavenging compounds. Keywords: Apricot, traditional sun-drying, oven-drying, carotenoids, phenolic compounds.

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Section: Discussionmentioning

confidence: 99%

Effect of traditional sun-drying and oven-drying on carotenoids and phenolic compounds of apricot (Prunus armeniaca L.)

Derardja¹,

Barkat²

2019

Nor. Afr. J. Food Nutr. Res.

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“…Studies [30,34,35] continue to support the beneficial effects of TDF specifically in traditional fruit juice beverages in enhancing perceived satiety, regulating energy intake, modulating gastric emptying, and reducing weight gain. Previous studies [36][37][38][39][40][41][42] have also supported the potential activity of some traditional Egyptian beverages as functional foods with antioxidative, antihypertensive, hypolipidemic, and anti-carcinogenic properties particularly in hibiscus tea, tamarind juice, dried apricot juice, and carob juice. In addition, the potential benefits of guava, strawberries, and pomegranate for the prevention of obesity and obesity-related diseases have been previously demonstrated [43][44][45][46][47][48].…”

Section: Discussionmentioning

confidence: 76%

Total Dietary Fiber Content of Selected Traditional Beverages in Egypt: A Brief Profile

Aboul‐Enein

2015

Beverages

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Escalating obesity rates have become a major public health concern in North Africa and the Middle East. Culturally-congruent dietary health education and strategies continue to be warranted to address this increasing public health crisis. Knowledge and familiarity with traditional foods and their nutritive value would assist public health practitioners in becoming culturally competent when educating on healthy eating patterns. The aim of this study is to provide a brief dietary profile of the total dietary fiber (TDF) contents of selected traditional beverages in Egypt. Five cookbooks for Egyptian food recipes were reviewed for traditional beverages. Beverage recipes (n = 19) were selected and reviewed for their TDF content using the United States Department of Agriculture (USDA) National Nutrient Database for Standard Reference (Release 27). The published values for TDF content were tabulated and reported per 100 mL of consumable portions. The highest TDF content was found in carob juice (8.0 g) and the lowest found in peppermint tea (0.0 g) with an overall TDF mean content of 2.8 g. Traditional beverages could be regarded as important sources of TDF within a healthy Egyptian dietary pattern. Cultural awareness and familiarities to traditional foods and their respective dietary profiles should be encouraged as an objective towards building culturally-competent health professionals and combating obesity in Egypt. Furthermore, developments of a traditional Egyptian food nutrient database for public access should be explored.

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“…Classical medicinal approaches rely on orthosteric and allosteric inhibitors for direct target inhibition. Approaches such as (a) preferential protein subtype selectivity [180,181], or species-specific selectivity [182,183], (b) cyclization or rigidification in inhibitor design [184][185][186][187][188][189], (c) targeting heterodimeric proteins or receptors [12,190,191]), (d) identification of toxicophore to pharmacophore [192][193][194][195], (e) repurposing of drugs of clinical agents [196], (f) inverse screening [197,198]), and (g) exploration of natural phytochemicals [199][200][201] have gained interest in the recent decade. As these approaches focus on small molecule inhibitors (SMIs) and their related modes of action; therefore, often have issues that are typical with occupancy-driven pharmacology (shown in Figure 1A), such as (a) frequent occurrence of resistance after prolonged use and, (b) require a higher degree of potency to achieve full inhibition of protein of interest (POI).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs

2022

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Targeting selective estrogen subtype receptors through typical medicinal chemistry approaches is based on occupancy-driven pharmacology. In occupancy-driven pharmacology, molecules are developed in order to inhibit the protein of interest (POI), and their popularity is based on their virtue of faster kinetics. However, such approaches have intrinsic flaws, such as pico-to-nanomolar range binding affinity and continuous dosage after a time interval for sustained inhibition of POI. These shortcomings were addressed by event-driven pharmacology-based approaches, which degrade the POI rather than inhibit it. One such example is PROTACs (Proteolysis targeting chimeras), which has become one of the highly successful strategies of event-driven pharmacology (pharmacology that does the degradation of POI and diminishes its functions). The selective targeting of estrogen receptor subtypes is always challenging for chemical biologists and medicinal chemists. Specifically, estrogen receptor α (ER-α) is expressed in nearly 70% of breast cancer and commonly overexpressed in ovarian, prostate, colon, and endometrial cancer. Therefore, conventional hormonal therapies are most prescribed to patients with ER + cancers. However, on prolonged use, resistance commonly developed against these therapies, which led to selective estrogen receptor degrader (SERD) becoming the first-line drug for metastatic ER + breast cancer. The SERD success shows that removing cellular ER-α is a promising approach to overcoming endocrine resistance. Depending on the mechanism of degradation of ER-α, various types of strategies of developed.

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Phytochemicals and Health Benefits of Dried Apricots

Cited by 5 publications

References 51 publications

Effect of traditional sun-drying and oven-drying on carotenoids and phenolic compounds of apricot (Prunus armeniaca L.)

Effect of traditional sun-drying and oven-drying on carotenoids and phenolic compounds of apricot (Prunus armeniaca L.)

Total Dietary Fiber Content of Selected Traditional Beverages in Egypt: A Brief Profile

Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs

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