Phytochemicals as Antidepressants

Khushboo, .; Kumar, Abhishek; Sharma, Bechan

doi:10.1007/978-981-15-2195-9_10

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…The IL‐6 stimulates the liver to produce hs‐CRP. [ 24 ] The most commonly used sepsis biomarkers in the routine lab are PCT and hs‐CRP. The role of hs‐CRP during acute inflammation is to bind the phospholipid components of microorganisms and damage host cells.…”

Section: Discussionmentioning

confidence: 99%

Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study

Cakir

Bozalı

Celikten

et al. 2022

J Biochem & Molecular Tox

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Since most infectious diseases can develop into sepsis, it is still a major medical problem. Some in‐vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis‐modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high‐sensitivity C‐reactive protein (hs‐CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), tumor necrosis factor‐alfa (TNF‐α), and monocyte chemoattractant protein‐1 (MCP‐1) levels were measured by enzyme‐linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL‐1β, IL‐6, TNF‐α, MPO activity, MCP‐1, hs‐CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti‐inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.

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Section: Discussionmentioning

confidence: 99%

Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study

Cakir

Bozalı

Celikten

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Life-time risk for major depression is roughly 5-12% for men and 10-25% for women. Major depression affects 3-5% of adolescents 3,4 . The pathophysiology of depression has been traditionally attributed to a neurotransmitter imbalance and critical interactions between genetic and environmental risk factors.…”

Section: Introductionmentioning

confidence: 99%