Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus

Ramírez‐Alarcón, Karina; Victoriano, Montserrat; Mardones, Lorena; Villagrán, Marcelo; Al‐Harrasi, Ahmed; Al‐Rawahi, Ahmed; Cruz‐Martins, Natália; Sharifi‐Rad, Javad; Martorell, Miquel

doi:10.3389/fendo.2021.656978

Cited by 26 publications

(16 citation statements)

References 176 publications

(169 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies on the phytochemistry of V. radiata have discovered flavonoids, alkaloids, phenolic compounds, and terpenoids [15,16]. e presence of secondary metabolites such as flavonoids, terpenoids, alkaloids, and phenolic chemicals is primarily responsible for the antidiabetic effect of some medicinal plants [13,[17][18][19][20][21]. V. radiata has also been utilized as a dietary food for the treatment of DM because it has a low glycemic index and high protein and fiber content [22,23].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Mung Bean or Vigna radiata (L.) Wilczek Seeds in Alloxan-Induced Diabetic Mice

Amare

Dires

Asfaw

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. Despite the development of oral hypoglycemic medications, diabetes and its associated complications continue to be significant clinical issues. The purpose of this study was to examine the antidiabetic effects of Vigna radiata (L.) Wilczek seeds in mice that had been given alloxan to cause diabetes. Methods. In Swiss albino mice, diabetes was brought on by a single intraperitoneal injection of the drug alloxan (150 mg/kg). For 14 days, glibenclamide (5 mg/kg) and methanol extract of V. radiata seeds (100, 200, and 400 mg/kg) were given orally. Following oral administration of V. radiata to mice, the blood glucose levels (BGL) and body weight were measured at 7 and 14 days. The mice were sacrificed at the end of the trial, and blood samples were taken for the evaluation of insulin, glycated hemoglobin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), high-density lipoprotein (HDL), total cholesterol (TC), and triglyceride (TG) levels. It was determined how much glycogen was present in the liver. Additionally, the total phenolic and flavonoid contents of V. radiata were determined, along with the in vitro DPPH (2, 2 diphenyl-1-picrylhrazyl) free radical-scavenging activity. P < 0.05 was chosen as the cutoff for statistical significance. Results. Following oral administration of V. radiata for 14 days, diabetic mice’s BGL and bad cholesterol (TC and TG) levels significantly decreased, while HDL levels increased. Treatment with V. radiata significantly decreased the levels of AST, ALT, and glycated hemoglobin when compared with diabetes control. On the other hand, it raised insulin levels and the amount of liver glycogen. V. radiata underwent phytochemical analysis, which identified the presence of tannins, saponins, phenols, alkaloids, terpenoids, steroids, flavonoids, and glycosides. Per gram of V. radiata seed extract, the total phenolic content was 43.12 ± 3.14 mg of gallic acid equivalents, while the total flavonoid content was 38.35 ± 2.6 mg of quercetin equivalents. Ascorbic acid was shown to have an IC50 value of 18.64 µg/ml during a DPPH-scavenging assay, while V. radiata had an IC50 value of 73.35 µg/ml. Conclusion. According to the findings of the current study, the methanolic extract of the seeds from the plant V. radiata possesses significant antidiabetic characteristics that are on par with those of the commonly used drug glibenclamide. Hence, V. radiata seems to be effective as a natural antidiabetic.

show abstract

Section: Introductionmentioning

confidence: 99%

Antidiabetic Activity of Mung Bean or Vigna radiata (L.) Wilczek Seeds in Alloxan-Induced Diabetic Mice

Amare

Dires

Asfaw

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…A high circulating adiponectin expression protects against insulin resistance, alleviates lipotoxicity of lipid accumulation and it is associated with reduced age-related tissue inflammation [166], effects that are enhanced by peroxisome proliferator-activated receptor-γ PPARγ trough up-regulating RUVBL2 (molecular chaperone for vesicle transport) expression as shown in 3 T3-L1 cells [167]. As mentioned, downregulation of PPARγ could diminish adipocyte differentiation, therefore it is crucial to identify effective agonists functioning as epidrugs that potentiate circulating adiponectin levels, such as panaxynol, isolated from Saposhnikovia divaricata, that can restore HMW adiponectin secretion affected by palmitic acid [168].…”

Section: Current and Future Epidrugs Against Environmental-pollution ...mentioning

confidence: 99%

Environmental Epigenetics and Obesity

Ramírez-Díaz¹,

Sagrario²,

Pérez-González³

et al. 2023

Epigenetics - Regulation and New Perspectives

View full text Add to dashboard Cite

In recent years, increasing interest on the effects of dietary components on epigenetic processes and, consequently, on the regulation of gene expression and metabolic responses has led clinical efforts worldwide to approach obesity. When inadequate, food consumption leads to chronic and non-communicable diseases (CNCD) including obesity. Among the dynamic changes in cellular responses by nutritional interventions, epigenetic control represents a master regulator underlying both positive and negative effects of diet on body mass, including DNA methylation, histone post-translational modifications and microRNA expression signatures. Indeed, mechanistical studies of the relationship between environment, diet and differential epigenetic landscapes are gaining attention on functional pathways involved in cell growth, DNA-repair, lipogenesis, senescence, inflammation, tumor suppression, apoptosis and oncogenesis. Being the dynamic interplay between epigenetics and obesity so complex, moreover considering a detrimental environment context, this chapter will discuss the state-of-the-art evidence showing the pollution impact on the different epigenetic mechanisms regulating an obese phenotype, and how these molecular events determine the organic interplay upon metabolic alterations, and finally we will introduce recent epidrugs and biocompounds of therapeutic interests due to their potential to modulate and even revert obesity-inducing epigenetic mechanisms.

show abstract

“…Phytochemicals are known to exert therapeutic effects on cancers, 84-87 cardiovascular diseases, [88][89][90][91] hypertension, 92 and diabetes. [93][94][95][96] Especially, flavonoids consist of various subclasses and present great potential as therapeutics that can reduce the risk of chronic diseases. 97 Based on the chemical skeleton, flavonoids can be classified into six groups, including anthocyanidins, isoflavonoids, flavonols, flavones, flavanols, and flavanones.…”

Section: Food and Function Papermentioning

confidence: 99%