Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity

Chen, Mingjun

doi:10.11648/j.jfns.20170502.11

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…Hyperglycemia is a dangerous and prevalent symptom in patients with diabetes, which has attracted extensive attention [1][2][3][4]. Hyperglycemia in animal models usually develops after long-term high-fat diet (HFD)-feeding and its progression may differ in different animal models [5,6].…”

Section: Introductionmentioning

confidence: 99%

Sargassum fusiforme Polysaccharides Prevent High-Fat Diet-Induced Early Fasting Hypoglycemia and Regulate the Gut Microbiota Composition

Wei

Zhong

et al. 2020

Marine Drugs

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A low fasting blood glucose level is a common symptom in diabetes patients and can be induced by high-fat diet (HFD) feeding at an early stage, which may play important roles in the development of diabetes, but has received little attention. In this study, five polysaccharides were prepared from Sargassumfusiforme and their effects on HFD-induced fasting hypoglycemia and gut microbiota dysbiosis were investigated. The results indicated that C57BL/6J male mice fed an HFD for 4 weeks developed severe hypoglycemia and four Sargassumfusiforme polysaccharides (SFPs), consisting of Sf-2, Sf-3, Sf-3-1, and Sf-A, significantly prevented early fasting hypoglycemia without inducing hyperglycemia. Sf-1 and Sf-A could also significantly prevent HFD-induced weight gain. Sf-2, Sf-3, Sf-3-1, and Sf-A mainly attenuated the HFD-induced decrease in Bacteroidetes, and all five SFPs had a considerable influence on the relative abundance of Oscillospira, Mucispirillum, and Clostridiales. Correlation analysis revealed that the fasting blood glucose level was associated with the relative abundance of Mucispinllum and Oscillospira. Receiver operating characteristic analysis indicated that Mucispinllum and Oscillospira exhibited good discriminatory power (AUC = 0.745–0.833) in the prediction of fasting hypoglycemia. Our findings highlight the novel application of SFPs (especially Sf-A) in glucose homeostasis and the potential roles of Mucispinllum and Oscillospira in the biological activity of SFPs.

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Section: Introductionmentioning

confidence: 99%

Sargassum fusiforme Polysaccharides Prevent High-Fat Diet-Induced Early Fasting Hypoglycemia and Regulate the Gut Microbiota Composition

Wei

Zhong

et al. 2020

Marine Drugs

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“…Mg 2+ can activate AMPK in a Ca 2+ -dependent manner that activates PFK-1 in the glycolytic pathway. [ 8 71 ] In addition, this cation can decrease the effect of glucagon in the liver. [ 13 25 ] Glucagon upregulates hepatic glucose production, glycogenolysis, gluconeogenesis, fatty acid oxidation, and lipolysis.…”

Section: Effects Of Mg 2+ On Glucose Metabolism In...mentioning

confidence: 99%

“…[ 25 ] In diabetic animals model, Mg 2+ supplementation downregulates the glucagon receptor that leads to improve insulin sensitivity. [ 71 ]…”

Section: Effects Of Mg 2+ On Glucose Metabolism In...mentioning

confidence: 99%

The Therapeutic Effects of Magnesium in Insulin Secretion and Insulin Resistance

Dastgerdi

Rad

Soltani

2022

Advanced Biomedical Research

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Insulin resistance (IR) is a chronic pathological condition that is related to reduce the rates of glucose uptake, especially in the liver, muscle, and adipose tissue as target tissues. Metabolic syndrome and type 2 diabetes mellitus can occur following progression of the disease. The majority of prior research has applied that some cations such as magnesium (Mg2+) have important physiological role in insulin metabolism. Mg2+ is the fourth most abundant mineral in the human body that gets involved as a cofactor of various enzymes in several metabolic events, such as carbohydrate oxidation, and it has a fundamental role in glucose transporting mechanism of the cell membrane. This cation has numerous duties in the human body such as regulation of insulin secretion in pancreatic beta-cells and phosphorylation of the insulin receptors in target cells and also gets involved in other downstream signal kinases as intracellular cation. On this basis, intracellular Mg2+ balancing is vital for adequate carbohydrate metabolism. This paper summarizes the present knowledge about the therapeutic effects of Mg2+ in reducing IR in liver, muscle, and pancreases with different mechanisms. For this, the search was performed in Google Scholar, PubMed, Scopus, and Web of Science by insulin resistance, skeletal muscle, liver, pancreases, magnesium, Mg2+, and inflammation keywords.

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“…Hyperglycemia also causes tissue damage through different mechanisms, including increased intracellular formation of advanced glycation end products (AGEs), increased expression of the receptor for AGEs, activation of protein kinase C isoforms etc. (2,3). According to the International Diabetes Federation, it is estimated that 415 million people of the world's population were suffering from DM in 2015 and it is expected to show a steady growth of 642 million by the year of 2040 (4).…”

Section: Introductionmentioning

confidence: 99%

Phytotherapy: Herbal medicine in the management of Diabetes mellitus

Bansode

Salalkar

2017

Plant Sci. Today

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Despite considerable progress in the treatment of the diabetes with synthetic drugs, the search for effective, safe and inexpensive drugs is ongoing from herbs, since they offer a wide range of antidiabetic agents. Antidiabetic studies using in silico, in vitro and in vivo aspect of different medicinal plant products (Trigonella foenum-graecum, seeds; Syzygium cumini, seeds; Salvadora persica, leaves and Terminalia chebula, seeds) were reviewed. The objective of the study was to compare these medicinal plants for their hypoglycemic effect and phytochemical composition in order to find out most feasible and efficient antidiabetic agent. In this regard, the article is going to look at the phytochemical profile and the antihyperglycaemic properties and toxicity studies of the various fractions isolated from these plants. Studies claimed that all crude as well as partially purified fractions showed an antidiabetic effect hence are potent antidiabetic agents, but maximum effect observed in case of fraction isolated from Syzygium cumini and Salvadora persica.

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Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity

Cited by 3 publications

References 28 publications

Sargassum fusiforme Polysaccharides Prevent High-Fat Diet-Induced Early Fasting Hypoglycemia and Regulate the Gut Microbiota Composition

Sargassum fusiforme Polysaccharides Prevent High-Fat Diet-Induced Early Fasting Hypoglycemia and Regulate the Gut Microbiota Composition

The Therapeutic Effects of Magnesium in Insulin Secretion and Insulin Resistance

Phytotherapy: Herbal medicine in the management of Diabetes mellitus

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