Phytochemicals of garlic: Promising candidates for cancer therapy

Zhang, Yan; Liu, Xing‐Ping; Ruan, Jun; Zhuang, Xuan; Zhang, Xinzong; Li, Zhiming

doi:10.1016/j.biopha.2019.109730

Cited by 136 publications

(106 citation statements)

References 59 publications

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“…Alliin forms the stable precursor for the formation of allicin. Alliin catalysed by alliinase form allicin, which is the major bioactive compound in garlic [ 16 , 17 ]. Alliin has demonstrated good antibacterial and anti-malignant properties [ 18 ].…”

Section: Sulphur Compoundsmentioning

confidence: 99%

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Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

et al. 2020

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Allium sativum (garlic) is widely known and is consumed as a natural prophylactic worldwide. It produces more than 200 identified chemical compounds, with more than 20 different kinds of sulfide compounds. The sulfide compounds particularly are proven to contribute to its various biological roles and pharmacological properties such as antimicrobial, antithrombotic, hypoglycemic, antitumour, and hypolipidemic. Therefore, it is often referred as disease-preventive food. Sulphur-containing compounds from A. sativum are derivatives of S-alkenyl-l-cysteine sulfoxides, ajoene molecules, thiosulfinates, sulfides, and S-allylcysteine. This review presents an overview of the water-soluble and oil-soluble sulphur based phytochemical compounds present in garlic, highlighting their mechanism of action in treating various health conditions. However, its role as a therapeutic agent should be extensively studied as it depends on factors such as the effective dosage and the suitable method of preparation.

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Section: Sulphur Compoundsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

et al. 2020

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“…Garlic and its peel fractions are good source of organosulfur. Studies suggest garlic and its by-products consumption to elicit antioxidant, anti-inflammatory and antitumor activities while a lot has already been published on anticancer properties of organosulfur (Zhang et al, 2020). Allyl derivatives of organo-sulfur compounds as intrinsic antioxidants have been reported in garlic that may further extend their chemo-preventive role against degenerative disorders (Murakami et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Nutritional composition of vegetables by-products / waste produced from vegetables processing indicate higher concentration of plant based dietary fiber (Silva et al, 2016). Adequate consumption of plant derived dietary fibers vide value addition and enrichment enable consumers to cope with the emerging health challenge (Yoon et al, 2005). Considerably higher levels of fiber ranging between 61 -125g.kg -1 peel of various potato cultivars have reported in different researches (Gumul et al, 2011;Ncobela et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Biochemical Characterization of Vegetables Wastes and Development of Functional Bread

Hashmi

Akhtar

Ismail

2021

J microb biotech food sci

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The present study aimed at evaluating nutritional potential and antioxidant activity of the extracts derived from vegetable wastes such as carrot pomace, onion upper bulbs, and peels from garlic, tomato & potato. Proximate composition, minerals profiling and antioxidants activity as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and trolox equivalent antioxidant capacity (TEAC) were estimated, and phenolics characterization was performed using high performance liquid chromatography (HPLC). Our results suggest that vegetable wastes such as peel and pomace, may be exploited as carriers of proteins, fiber, calcium, potassium, iron and zinc. Phenolics screening demonstrated presence of total hydroxybenzoic, hydroxylcinammic acids and catechin albeit anthocyanins and total flavonols were inadequately present in tomato pomace. Maximum total phenolics contents and DPPH activity were observed in HCl/MeOH extracts of tomato and garlic peels, respectively. Product development data suggest incorporating onion peel’s extracts in wheat flour to not elicit a significant change in bread composition. Likewise, supplementation of onion peel powder (OPP) and extracts @ 6% and 1.5%, respectively improved color and textural properties of supplemented bread. Contextualizing the challenges of food insecurity and food industry waste management, our results confirmed that vegetable wastes, with improved nutritional profile and increased antioxidant potential, may be used for the preparation of value-added food products.

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“…Clinical trial data of various forms of garlic are inconsistent because of the significant difference in the bioavailability of the constituents in raw garlic and the specific garlic supplement formulations [586].…”

Section: Clinical and Epidemiological Studiesmentioning

confidence: 99%

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

et al. 2020

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Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basic and clinical research on developing alternative anticancer therapies.

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Phytochemicals of garlic: Promising candidates for cancer therapy

Cited by 136 publications

References 59 publications

Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

Biochemical Characterization of Vegetables Wastes and Development of Functional Bread

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

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