Phytochemistry and anti‐inflammatory activity of iridoids from Dolichandrone spathacea collected in the mangrove forest of Phu Loc district, Thua Thien Hue province, Vietnam

Abstract

From the leaves and barks of Dolichandrone spathacea collected in the mangrove forest of Hue province, three iridoids {6‐O‐[(E)‐4‐methoxy cinnamoyl]catalpol (1), 6‐O‐[(E)‐3,4‐dimethoxy cinnamoyl]catalpol (2), nemoroside (3)} and three ursane‐type triterpenoids [ursolic acid (4), pomolic acid (5), uncaric acid (6)] were isolated and structurally elucidated. Besides, succrose octaacetate (7), daucosterol tetraacetate (8) and 1‐hentriacontanol (9) were identified from the fruits of this mangrove species. It is the first time compounds 6, 7, 9 were isolated from Dolichandrone spathacea. The main constituents of this plant, iridoids 1 and 2, were tested for the inhibition of IL‐6, TNF‐α factors and NO production. The anti‐inflammatory activity as well as the phytochemistry of the fruits of this species are reported for the first time.

Xanthine oxidase inhibition study of isolated secondary metabolites from Dolichandrone spathacea (Bignoniaceae): In vitro and in silico approach

“…The seeds exhibit disinfectant properties, and the stems are employed in traditional medicine to treat bronchitis ( Jackes, 2017 , Nguyen et al, 2018 , Van Tuan et al, 2018 ). The phytochemical constituents of this plant were investigated, revealing saponins, flavonoids, phenylethanoid glycosides, iridoids, triterpenoids, steroids, and phenolics constitute the primary bioactive constituents ( Nguyen et al, 2016 , Thao et al, 2021 ). Earlier pharmacological studies have shown that it exhibits antioxidant and anti-hyperglycemic effects ( Kaewpiboon et al, 2012 , Van Tuan et al, 2018 ) and antimicrobial activity ( Saiful et al, 2011 , Nguyen et al, 2018 ).…”