Phytochemistry and Antibacterial Activity of Senna alata Flower

Abstract

Phytochemistry and antibacterial potency of some crude and partially purified fractions of Senna alata flower was examined against 22 bacterial strains. The crude plant extracts, containing steroids, anthraquinone glycosides, volatile oils and tannins, exhibited a high minimum inhibitory concentration of 500 mg/mL against Staphylococcus aureus, Streptococcus faecalis, Micrococcus luteus, Bacillus subtilis and Pseudomonas putida, but was generally inactive against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Serratia marcescens, and Pseudomonas fluorescens (above 1000 mg/mL). However, the partially purified plant extract was bacteriostatic at a low concentration of 100 mg/mL, with a minimum bactericidal concentration of 500 mg/mL, primarily against the Gram positive organisms. At a concentration slightly above the minimum inhibitory concentration, the purified extract was nearly as potent as standard antibiotics, exhibiting zones of bacterial growth inhibition ranging from 10 to 25 mm, even against multiple antibiotic resistant local isolates that were not susceptible to methicillin, penicillin and streptomycin.

A medicinal herbCassia alataattenuates quorum sensing inChromobacterium violaceumandPseudomonas aeruginosa

“…Existing reports suggest its potential activity against fungi; however, its activity against bacteria was ambiguous with varying MIC values (Ibrahim and Osman ; Adedayo et al . ; Somchit et al . ; El‐Mahmood and Doughari ).…”

“…Among the different plant parts, the leaves have higher use in traditional medicine compared to other parts. Existing reports suggest its potential activity against fungi; however, its activity against bacteria was ambiguous with varying MIC values (Ibrahim and Osman 1995;Adedayo et al 2001;Somchit et al 2003;El-Mahmood and Doughari 2008). In this study, anti-QS activity of Ca.…”

Senna alata

“…The crude S. alata fl ower extracts, containing steroids, anthraquinone glycosides, volatile oils and tannins, exhibited a high MIC of 500 μg/mL against Staphylococcus aureus, Streptococcus faecalis, Micrococcus luteus, Bacillus subtilis and Pseudomonas putida but was generally inactive against Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Serratia marcescens and Pseudomonas fl uorescens (MIC >1,000 μg/mL) (Adedayo et al 2001 ). However, the partially purifi ed fl ower extract was bacteriostatic at a low concentration of 100 μg/mL, with a minimum bactericidal concentration of 500 μg/mL, primarily against the Gram-positive organisms.…”

Effect of <i>Senna alata</i> (L) Roxb (Fabaceae) Leaf Extracts on alpha-Amylase, alpha-Glucosidase and Postprandial Hyperglycemia in Rats

“…Roxb (Leguminosae), known as Ringworm plant, winged senna, craw-craw plant or king of the forest, is of great importance in traditional medical practice in many developing countries [1]. In Nigeria, it is called 'Asunwon oyinbo' and 'Nelkhi' in the Western and Eastern regions of the country respectively.…”

“…The whole plant is used in Brazil, Guatemala and Guinea in the treatment of malaria, flu and other infectious diseases [3]. Studies have also reported the antibacterial, antifungal and antiviral properties of S. alata leaf [1,6] as well as its laxative [3] and abortifacient properties in wistar rats [2]. Of particular interest is its use in the management of sugar-related disorders such as diabetes mellitus and hyperglycaemia [5][6][7].…”