Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities

Yi, Lunzhao; Ma, Shuanhong; Ren, Dabing

doi:10.1007/s11101-017-9497-1

Cited by 113 publications

(91 citation statements)

References 282 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavanones: The flavanones hesperetin and naringenin undergo transformation by neohesperidose and rutinose becoming flavanone glycosides hesperidin, neohesperidin, narirutin, and naringin [51]. Hesperetin is apoptotic to A431 epidermoid skin carcinoma via cyclin and MAPK regulation [51].…”

Section: Phenolsmentioning

confidence: 99%

“…Hesperetin is apoptotic to A431 epidermoid skin carcinoma via cyclin and MAPK regulation [51]. Naringenin is effective against A431, B16-F10 melanoma, and in vivo HepG2 cells [51].…”

Section: Phenolsmentioning

confidence: 99%

“…Hesperetin is apoptotic to A431 epidermoid skin carcinoma via cyclin and MAPK regulation [51]. Naringenin is effective against A431, B16-F10 melanoma, and in vivo HepG2 cells [51]. In murine models, Naringenin dosed at 50 mg/kg body weight suppresses lung cancer [51].…”

Section: Phenolsmentioning

confidence: 99%

“…Naringenin is effective against A431, B16-F10 melanoma, and in vivo HepG2 cells [51]. In murine models, Naringenin dosed at 50 mg/kg body weight suppresses lung cancer [51]. Naringenin induces G0/G1 and G2/M phase cell cycle arrest, ROS generation, and down regulates TGF-β1 [51].…”

Section: Phenolsmentioning

confidence: 99%

See 3 more Smart Citations

Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

View full text Add to dashboard Cite

Statement of Purpose: Although 75% of breast cancer patients may use integrative medicine, only 11.5% earlystage breast cancer patients believe integrative medicine has anticancer activity. The gap in users of and firm believers in integrative medicine indicates a need to increase awareness of integrative medicine's applicability to curative cancer treatment. As diet, nutraceuticals, and traditional Chinese medicine are used by up to 82% of cancer patients who use integrative medicine, this paper focuses on nutraceuticals. As female cancer patients are most likely to use integrative medicine, nutraceuticals specific to breast, cervical, endometrial, and ovarian cancer are reviewed.Methods: PubMed searches in September 2016 and January 2017, and accompanying hand searches were performed for English language, free full text articles published from 2012 onwards. Search terms were combinations of the key words: Homeopathy, phytochemicals, breast cancer, cervical cancer, endometrial cancer, ovarian cancer, cancer, prevention, treatment. Curative nutraceutical treatments were taken from these searches. Supplemental hand searches were performed as needed. Findings:Integrative nutraceutical therapies are based on biologic plausibility. Individual nutraceuticals are frequently comprised of numerous phytochemical types, and have multiple mechanisms of action. Agonistantagonist mechanisms are not exclusive to phytoestrogens, complicating which derivative or whole nutraceutical to use. Research on breast and cervical cancer inhibitors has seemingly outpaced that for endometrial and ovarian cancer. Breast cancer inhibitors include terpenes, isoflavones, organosulphurs, organoselenium compounds, and withanolides. Conclusion and Significance:Potential nutraceutical candidates for curative cancer treatment abound. Discerning which constituents, which extraction method, and which delivery method to use for an efficacious treatment is an essential, lengthy process. If nutraceuticals such as limonene and Kahalalide F move forward to Phase III trials a nutraceutical cancer treatment pipeline may be established. Withaferin-A and derivatives for breast and ovarian cancer appear to be the leading gynecologic cancer nutraceutical drug candidates.

show abstract

Section: Phenolsmentioning

confidence: 99%

“…Hesperetin is apoptotic to A431 epidermoid skin carcinoma via cyclin and MAPK regulation [51]. Naringenin is effective against A431, B16-F10 melanoma, and in vivo HepG2 cells [51].…”

Section: Phenolsmentioning

confidence: 99%

Section: Phenolsmentioning

confidence: 99%

Section: Phenolsmentioning

confidence: 99%

See 2 more Smart Citations

Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

View full text Add to dashboard Cite

show abstract

“…Based investigation, T. portulacastrum has been found to control oxidative stress and inflammation on the animal model; however, the clinical data are yet inadequate. Yi et al (2017) outlined the health-related properties of Citrus flavonoids, including antioxidant activity, anticancer activity, anti-inflammatory activity, and cardiovascular protection. Significant clinical studies with purified Citrus flavonoids should be performed to clarify their benefits in humans.…”

mentioning

confidence: 99%

2nd international symposium on phytochemicals in medicine and food (2-ISPMF)

2017

View full text Add to dashboard Cite

Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666‐1 cells through regulating PARP‐2/SIRT1/AMPK signaling pathway

Zheng

Chao

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

Background/Aim Nobiletin, a major polymethoxyflavones ( PMF s) from citri reticulatae pericarpium ( CRP ), can inhibit several forms of cancer proliferation. However, the effects of nobiletin on nasopharyngeal carcinoma ( NPC ) C666‐1 cells remain largely unknown. Materials and Methods Cell counting kit 8 ( CCK 8) assay was used to measure cell vitality. Flow cytometry was performed to measure the apoptosis rate. Quantitative real‐time polymerase chain reaction ( qRT ‐ PCR ) and Western blot analysis were applied to determine the expression of mRNA and protein, respectively. Results We showed that the proliferation rate of C666‐1 cells was inhibited and the apoptosis rate was raised after treating with nobiletin. Moreover, nobiletin inhibited the expression of poly( ADP ‐ribose)polymerase‐2 ( PARP ‐2), and the tumor suppression effect of nobiletin on C666‐1 is associated with PARP ‐2‐dependent pathway. Conclusion We demonstrated for the first time that nobiletin inhibited the growth of C666‐1 cells, which may be relative to its regulation on PARP ‐2/ SIRT 1/ AMPK signaling pathway. Our result implied that nobiletin may serve as a strategy to treat nasopharyngeal carcinoma.

show abstract

Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities

Cited by 113 publications

References 282 publications

Nutraceuticals: Curative Integrative Cancer Treatment

Nutraceuticals: Curative Integrative Cancer Treatment

2nd international symposium on phytochemicals in medicine and food (2-ISPMF)

Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666‐1 cells through regulating PARP‐2/SIRT1/AMPK signaling pathway

Contact Info

Product

Resources

About