Phytochemistry and bioactivity of triterpene saponins from Amaranthaceae family

Mroczek, Agnieszka

doi:10.1007/s11101-015-9394-4

Cited by 80 publications

(53 citation statements)

References 72 publications

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“…For amaranth, only sapogenins of the olean-5-en-type, carboxylated in C-17-position had been identified so far (Mroczek, 2015). Based on the similarity of the fragmentation patterns of the compounds known from literature and the uncharacterized signals in the present analysis, it is likely that they possess the same sapogenin backbone.…”

Section: Purification With Preparative Hplc and Fragmentation Using Imentioning

confidence: 57%

“…Furthermore, literature data indicates glucose (Glc) and rhamnose (Rha) as the dominating sugars for triterpeniod saponins in Amaranthaceae. A peculiarity of many saponins in amaranth is the presence of glucuronic acid (GluA), which is bound to the sapogenin in C-3-position (Mroczek, 2015).…”

Section: Purification With Preparative Hplc and Fragmentation Using Imentioning

confidence: 99%

“…Sugar chains can be linear or branched and in most cases consist of 1-3 sugar units. Glucuronic acid and glucose are the most frequent monomers directly attached to the sapogenin in Amaranthaceae (Mroczek, 2015).…”

mentioning

confidence: 99%

“…Several biological activities have been assigned to saponins including anti-inflammatory, anti-microbial, anti-parasitic, anti-tumor, and anti-viral, but also adverse cytotoxic and hemolytic effects (Mroczek, 2015;Sparg, Light, & van Staden, 2004). Most of these effects result from the structural peculiarity of the non-polar sapogenin in combination with the high polar sugar moieties.…”

mentioning

confidence: 99%

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Identification of novel saponins in vegetable amaranth and characterization of their hemolytic activity

Zehring

Reim

Schröter

et al. 2015

Food Research International

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Section: Purification With Preparative Hplc and Fragmentation Using Imentioning

confidence: 57%

Section: Purification With Preparative Hplc and Fragmentation Using Imentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Identification of novel saponins in vegetable amaranth and characterization of their hemolytic activity

Zehring

Reim

Schröter

et al. 2015

Food Research International

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“…rutin, nicotiflorin, isoquercitrin, 4-hydroxybenzoic and p-coumaric acids were identified as major constituents. In the review article by Mroczek (2015) it is reported that saponins were isolated from a diversity of Amaranthaceae genera and species. In this study, the total phenolic and flavonoid content significantly declined in A. cruentus plants exposed to hot temperatures compared to plants grown at the optimal temperature (Table 1).…”

Section: Metabolitesmentioning

confidence: 99%

Impact of temperature stress on secondary metabolite profile and phytotoxicity of Amaranthus cruentus L. leaf extracts

Cawood

Allemann

2018

AAS

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In this study <em>Amaranthus cruentus</em> plants were grown under controlled optimal conditions (28/21 °C) for three months and then subjected to cold (14/7 °C) and hot (33/40 °C) temperatures. We investigated the influence of these temperature regimes on the metabolite profile of the leaves through analyses of data by TLC, HPLC and GC-MS spectrometry. The phytotoxic potential of a methanol-water (MW) and dichloromethane (DCM) extract from the aerial parts were examined through in vitro screening of germination and growth of lettuce and pepper. The optimal extracts displayed the highest diversity of secondary metabolites, and the highest total phenolics and flavonoids content. Through TLC and HPLC analysis the significantly lower phenolic content in the hot temperature treated samples was confirmed. A wide range of metabolites were detected in the DCM extracts through GC-MS analyses. The phytotoxicity of both the MW and DCM extracts were demonstrated, as germination and growth of pepper and lettuce were significantly inhibited, indicating the presence of more than one allelochemical compound which may affect the allelopathic activity of <em>A. cruentus</em> during changes in environmental temperatures.

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Investigation of the Apoptotic and Antimetastatic Effects of Nano‐Niosomes Containing the Plant Extract Anabasis setifera on HeLa: In Vitro Cervical Cancer Study

Ebadi,

Kavousi,

Farahmand

2024

Chemistry & Biodiversity

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The present study focuses on the preparation of niosomes containing an extract of Anabasis setifera&evaluates their efficacy in inhibiting the growth&proliferation of HeLa.Thin‐layer hydration technique was used to prepare niosomes/extract nanoparticles(NPs).The physicochemical properties of the synthesized NPs were confirmed by SEM,DLS,zeta potential analysis&FTIR.The cytotoxicity of free extract,free niosome&NPs was investigated by MTTassay.For this purpose,solutions of the three mentioned agents were prepared&diluted in 400,200,100,50,25,12.5&6.25µg/ml concentrations&incubated for24,48&72 hours.After calculating the IC50 concentration&treating the cells with this concentration,Real‐time‐PCR(to measure changes in the expression of apoptosis and metastasis genes),flowcytometry(to determine the amount of early and late induced apoptosis)&cellcycle test(to determine the stopping stage of the cancer cell division cycle)were performed.Also,the scratch test(The ability to inhibit cell metastasis after treatment)was used to evaluate cell migration.The MTTassay results showed that 72hours of treatment with NPs has the greatest effect on the death of cancer cells.Real‐time PCR showed that the expression of the Bad gene increased dramatically and the expression of the BCL‐XL,ITGA5&ZEB‐1 decreased significantly.The flowcytometry results showed that 48.64% of HeLa cells underwent apoptosis after treatment with synthesized NPs.The scratch test results showed that cancer cell metastasis stopped after treatment with NPs.The research demonstrates the significant potential of NPs,as highly efficient drug carriers for cancer therapy

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Phytochemistry and bioactivity of triterpene saponins from Amaranthaceae family

Cited by 80 publications

References 72 publications

Identification of novel saponins in vegetable amaranth and characterization of their hemolytic activity

Identification of novel saponins in vegetable amaranth and characterization of their hemolytic activity

Impact of temperature stress on secondary metabolite profile and phytotoxicity of Amaranthus cruentus L. leaf extracts

Investigation of the Apoptotic and Antimetastatic Effects of Nano‐Niosomes Containing the Plant Extract Anabasis setifera on HeLa: In Vitro Cervical Cancer Study

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