Phytochemistry and biological properties of Drimys winteriJR et G. Forster var chilensis(DC) A.

Muñoz, Orlando; Tapia, Jorge; Nevermann, Wolf; San-Martı́n, Aurelio

doi:10.37360/blacpma.21.20.5.33

Cited by 4 publications

(5 citation statements)

References 72 publications

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“…Antioxidants are compounds that protect tissues from damage caused by free radicals, which are highly reactive molecules that damage cellular machinery, contributing to aging and the onset of various diseases, Coronado H et al (2015). Muñoz et al (2021) demonstrated that DW_EO significantly reduced AAPH-induced lipid oxidation and spontaneous oxidation in bovine meat relative to the control group, even more effectively than BHT. In addition, a protective effect on protein structure was observed during incubation with DW_EO compared to samples incubated with AAPH.…”

Section: Antioxidant Potentialmentioning

confidence: 99%

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Biological activity of the essential oil of Drimys winteri

Navarro,

Urrejola,

Espinoza

et al. 2024

Front. Chem.

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In the Chilean indigenous culture, the tree Drimys winteri (Winteraceae) Canelo is of great importance and is considered the sacred Mapuche tree. It has antibacterial and disinfectant properties and is used in the treatment of various diseases, such as fevers, ulcers, cancers, and respiratory tract problems. The essential oil obtained from D. winteri, DW_EO, is bioactive, possesses insecticidal and repellent properties against pests, and shows activity toward plant growth regulators. It also has a phytotoxic effect against the growth and germination of weeds. The essential oil obtained from the leaves and bark of Drimys winteri has demonstrated antifungal, immunomodulatory, anti-inflammatory, and anticancer properties in in vitro and in vivo studies. It also possesses antioxidant activity and antibacterial effects. The essential oil contains monoterpenes such as zafrol, pinenes, and linalool, among others, that contribute to its bioactivity. The DW_EO and bioactive compounds have great potential in various applications in medicine, industrial food, sanitizer, and other areas.

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Section: Antioxidant Potentialmentioning

confidence: 99%

“…It is always in leaf, and from January to June, it blooms. It is a hermaphrodite species ( Munoz et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Biological activity of the essential oil of Drimys winteri

Navarro,

Urrejola,

Espinoza

et al. 2024

Front. Chem.

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“…The results obtained for antimicrobial activity for DW_EO, show a greater effect on gram-positive bacteria compared to gram-negative bacteria and yeast, highlighted S. aureus (MIC 8 μg/ml), even if it is compare with the effect its major components β-Caryophyllen and γ -Eudesmol (MIC 64 μg/ ml). There are no studies of the DW_EO in the strains, however, the antifungal activity of front phytopathogenic fungi and insecticidal properties has been described (Muñoz et al, 2021). Essential oils (EOs) offer a plethora of bioactivities including antioxidant, anti-mutagenic, and antiproliferative properties.…”

Section: Compound Cyp2c9mentioning

confidence: 99%

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

Bruna

Fernández²,

Urrejola³

et al. 2022

Front. Nat. Prod.

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The Mapuche and their ancestors have used D. winteri in traditional medicine. In the present study, the essential oil extract of D. winteri leaves (DW_EO) were characterized chemically and biologically to evaluate its pharmacological activity. In vitro antioxidant activity was assayed, and antitumor activity was evaluated in non-tumor and tumor-cell culture lines. Caenorhabditis elegans was used as a model to evaluate toxicity, and the chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry. The chemical oil composition was characterized principally of five major terpenes: 4 sesquiterpenes γ-Eudesmol (39.7%), β-Caryophyllene (33.7%), Elemol (25.9%), α-Eudesmol (0.3%) and 1 diterpene Kaunene (0.4%). By quantum calculations, it was determined that all oils have the ability to capture and yield electrons, which is consistent with the moderate antioxidant activity of DW_EO detected in vitro. Furthermore, by molecular docking is estimated that these oils can bind to proteins involved in the production of oxygen radicals. Of these proteins, CYP2C9 could bind energetically, reaching binding energy between −6.8 and −9.2 kCal/mol for the 5 terpenes studied, highlighting among these β-Caryophyllen and γ-Eudesmol. DW_EO has effect against H. pylori (MIC 32 μg/ml), S. aureus (MIC 8 μg/ml), E. coli (MIC 32 μg/ml) and C. albicans (MIC 64 μg/ml), β-Caryophyllen and γ -Eudesmol (MIC 64 μg/ml) and could selectively inhibit the proliferation of epithelial tumor cell lines but showed low against C. elegans (0.39–1.56 μg mL−1). Therefore, DW_EO may be used as a source of bioactive compounds in novel pharmacological treatments for medical application, agronomics, sanitation, and food.

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Section: Introductionmentioning

confidence: 99%

“…chilensis, as well as various lignanes such as sesamin, (−) cubebin, and eudesmin. In addition, according to the literature, many flavonoids such as apigenin, luteolin, kaempferol, quercitrin, taxifolin, quercetin, cirsimaritin, fisetin, and astilbin have been reported and isolated but only from bark and leaves of this endemic tree [5]. Our group has previously reported on extracts and some pure compounds from various endemic species in Chile that have potent enzymatic inhibitory effects or other bioactivities linked to ameliorating noncommunicable diseases (NCDs) and neurodegenerative diseases and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (Drimys winteri J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits

Barrientos,

Romero-Parra,

Cifuentes

et al. 2023

Foods

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Drimys winteri J.R. Forst. & G. Forst (D.C) G. Gray, var. chilensis (canelo) is an endemic tree from Chile. Since pre-Columbian times, it has produced a fruit known as the canelo pepper, (pimienta de canelo) or Foye pepper, which can be used as a spice. The chemical and biological analysis of canelo fruits is reported for the first time in this study, that is, its phenolic fingerprinting by UHPLC-PDA- Q-orbitrap MS, the antioxidant activity, the enzymatic inhibitory activity, and its relaxation effects on rat aorta. The proximal composition and the mineral content (Ca: 1.45 ± 0.03 mg/100 g; Mg: 7.72 ± 0.03 mg/100 g; Fe: 4.54 ± 0.21 mg/100 g; Zn: 2.99 ± 0.02 mg/100 g; Mn: 1.08 ± 0.03 mg/100 g; Cu: 0.82 ± 0.02 mg/100 g; K: 53.03 ± 0.20 mg/100 g; Na: 0.087 ± 0.00 mg/100 g) are also reported. The canelo fruits showed a total phenolic content of 57.33 ± 0.82 mg GAE/g dry weight. In addition, the total flavonoid content was 38.42 ± 1.32 mg equivalent of QE/g dry weight. The antioxidant activity was evaluated by employing DPPH and ABTS methods (IC50 of 6.65 ± 0.5 and 9.5 ± 0.05 μg/mL, respectively), ORAC (25.33 ± 1.2 μmol Trolox/g dry plant) and FRAP (45.56 ± 1.32 μmol Trolox/g dry plant). The enzymatic inhibition of acetylcholinesterase, butyrylcholinesterase, and tyrosinase (IC50: 1.94 ± 0.07, 2.73 ± 0.05, and 9.92 ± 0.05 µg extract/mL, respectively) is also reported. Canelo extract led to an 89% relaxation of rat aorta. Our results confirm that D. winteri fruits are a rich source of secondary metabolites and can inhibit enzymes associated with neurodegenerative diseases; the results also suggest that canelo may induce a potentially hypotensive effect in rat aorta. The study demonstrates the medicinal properties of canelo fruit and spice.

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Phytochemistry and biological properties of Drimys winteriJR et G. Forster var chilensis(DC) A.

Cited by 4 publications

References 72 publications

Biological activity of the essential oil of Drimys winteri

Biological activity of the essential oil of Drimys winteri

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

Chemical Fingerprinting, Aorta Endothelium Relaxation Effect, and Enzymatic Inhibition of Canelo (Drimys winteri J. R. Forst. & G. Forst, (D.C) A. Gray, Family Winteraceae) Fruits

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