Phytochemistry and Diverse Pharmacology of Genus Mimosa: A Review

Majeed, Ismat; Bilal, Muhammad; Rasheed, Tahir; Shakeel, Ahmad; Iqbal, Shahid

doi:10.3390/biom12010083

Cited by 16 publications

(19 citation statements)

References 98 publications

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“…In addition, scientific consistency of all medicinal uses is supported by numerous studies highlighting the anticancer [10], antihypertensive, antidiabetic [11], antiinflammatory, antiplasmodial [12], antibacterial [13,14], anti-HIV [15], antiparasitic [16], antioxidant [17,18] and enzyme inhibitory [19,20] properties of extracts and/or secondary metabolites isolated from this plant. Similar broad range of pharmacological activities has been observed with respect to the Mimosa genus [21,22].…”

Section: Introductionsupporting

confidence: 77%

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

et al. 2022

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Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date. We first characterized by conventional reactions the composition of several stem bark extracts and evaluated in acellular and cellular assays their pro- or antioxidant properties supported by their high phenolic and flavonoid content, particularly with the methanolic extract. The pro- or antioxidant effects observed did not correlate with their IC50 concentrations against five cancer cell lines determined by MTT assay. Indeed, the CH2Cl2 extract and its ethyl acetate (EtOAc) subfraction appeared more potent although they harbored lower pro- or antioxidant effects. Nevertheless, at equipotent concentration, both extracts induced ER- and mitochondria-derived vacuoles observed by fluorescent microscopy that further led to non-apoptotic cell death. LC coupled to high resolution MS investigations have been performed to identify chemical compounds of the extracts. These investigations highlighted the presence of compounds formerly isolated from E. senegalensis including senegalensein that could be retrieved only in the EtOAc subfraction but also thirteen other compounds, such as 16:3-Glc-stigmasterol and hexadecanoic acid, whose anticancer properties have been previously reported. Nineteen other compounds remain to be identified. In conclusion, E. senegalensis appeared rich in compounds with antioxidant and anticancer properties, supporting its use in traditional practice and its status as a species of interest for further investigations in anticancer drug research.

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Section: Introductionsupporting

confidence: 77%

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

et al. 2022

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“…A thorough analysis of the literature found that Mimosa pudica contains several marker compounds. e different fractions were found to have varied proportions and composition of constituents [30]. e 14 different chemicals (Figure 3) from the ethyl acetate extract of Mimosa pudica were isolated in a study conducted by Patel and Bhutani [31].…”

Section: Bioactive Compounds In Eamp Through Literaturementioning

confidence: 99%

In Vitro Antioxidant and Antimicrobial Potency of Mimosa pudica of Nepalese Terai Region: Insight into L-Mimosine as an Antibacterial Agent

Mandal¹,

Pandey

Sah³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aim. The study aimed to evaluate the in vitro antioxidant and antimicrobial potency of Mimosa pudica found wildly in the Terai region of Nepal and assess its physicochemical properties, such as total phenolic content (TPC) and total flavonoid content (TFC). Materials and Methods. The physicochemical properties of ethyl acetate extract of Mimosa pudica (EAMP), such as extractive value, total ash content, loss on drying, and phytochemical screening, were calculated using standard protocols. The TPC was determined by using the Folin–Ciocalteu method taking gallic acid as standard, and TFC was conducted by using the AlCl3 colorimetric method, using a 96-well plate reader. The in vitro antibacterial activity of different concentrations of the extract against four bacterial ATCC strains was determined by the agar well diffusion method in the Mueller Hinton agar (MHA) medium. The in silico molecular docking model was used to ascertain the antibacterial potency of L-mimosine against the selected strains of bacteria used for the in vitro study by calculating the binding affinity towards the protein of bacteria. Results. The preliminary screening of the extract showed the presence of several phytochemicals. The total ash content (7.67%), loss on drying (2.30%), and extractive value (8.966%) were determined by analyzing the crude sample. The total phenolic and flavonoid contents were 418.640 ± 0.018 mg GAE/g (dried extract) and 14.126 ± 0.021 mg QE/g (dried extract), respectively. The extract showed a potent free radical scavenging activity with an IC50 value of 158.95 ± 1.12 µg/mL. The plant extract also demonstrated the antibacterial activity against both Gram-positive bacteria Staphylococcus aureus (15 mm) and Bacillus cereus (22 mm) and Gram-negative bacteria Escherichia coli (17 mm) and Klebsiella pneumoniae (16 mm) at 200 mg/mL concentration of extract. There was a noteworthy binding affinity of antibiotics with almost all selected bacterial proteins with binding energy against Escherichia coli DNA gyrase subunit B (−5.7 kcal/mol), Staphylococcus aureus DNA gyrase subunit B (−6.1 kcal/mol), Bacillus cereus metallothiol transferase (−5.2 kcal/mol), and Klebsiella pneumoniaebeta-lactamase (−6.1 kcal/mole), respectively, with the L-mimosine. Conclusion. The findings of the current study suggest that Mimosa pudica from the Terai region of Nepal is rich in phenolic and flavonoid compounds, has a significant impact on bacterial growth inhibition, and has a notable potential to scavenge free radicals (DPPH). According to the in silico analysis, L-mimosine is a potent antibacterial compound that might be utilised to discover novel antibacterial drugs to combat antibiotic resistance.

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“…Figure S1: Per-residue energy decomposition of PDE5-APO (Black), PDE5-BUF (Green), PDE5-STI (Yellow), PDE5-ISV (Blue), PDE5-APT (Red) and PDE5-STD drug Sildenafil (Brown). Refs [72][73][74][75][76][77][78] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach

et al. 2022

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Plants and their derived molecules have been traditionally used to manage numerous pathological complications, including male erectile dysfunction (ED). Mimosa pudica Linn. commonly referred to as the touch-me-not plant, and its extract are important sources of new lead molecules in drug discovery research. The main goal of this study was to predict highly effective molecules from M. pudica Linn. for reaching and maintaining penile erection before and during sexual intercourse through in silico molecular docking and dynamics simulation tools. A total of 28 bioactive molecules were identified from this target plant through public repositories, and their chemical structures were drawn using Chemsketch software. Graph theoretical network principles were applied to identify the ideal target (phosphodiesterase type 5) and rebuild the network to visualize the responsible signaling genes, proteins, and enzymes. The 28 identified bioactive molecules were docked against the phosphodiesterase type 5 (PDE5) enzyme and compared with the standard PDE5 inhibitor (sildenafil). Pharmacokinetics (ADME), toxicity, and several physicochemical properties of bioactive molecules were assessed to confirm their drug-likeness property. Molecular dynamics (MD) simulation modeling was performed to investigate the stability of PDE5–ligand complexes. Four bioactive molecules (Bufadienolide (−12.30 kcal mol−1), Stigmasterol (−11.40 kcal mol−1), Isovitexin (−11.20 kcal mol−1), and Apigetrin (−11.20 kcal mol−1)) showed the top binding affinities with the PDE5 enzyme, much more powerful than the standard PDE5 inhibitor (−9.80 kcal mol−1). The four top binding bioactive molecules were further validated for a stable binding affinity with the PDE5 enzyme and conformation during the MD simulation period as compared to the apoprotein and standard PDE5 inhibitor complexes. Further, the four top binding bioactive molecules demonstrated significant drug-likeness characteristics with lower toxicity profiles. According to the findings, the four top binding molecules may be used as potent and safe PDE5 inhibitors and could potentially be used in the treatment of ED.

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Phytochemistry and Diverse Pharmacology of Genus Mimosa: A Review

Cited by 16 publications

References 98 publications

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

In Vitro Antioxidant and Antimicrobial Potency of Mimosa pudica of Nepalese Terai Region: Insight into L-Mimosine as an Antibacterial Agent

Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach

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