Phytochemistry and pharmacognosy of the genus Acronychia

Epifano, Francesco; Fiorito, Serena; Genovese, Salvatore

doi:10.1016/j.phytochem.2013.07.013

Cited by 31 publications

(35 citation statements)

References 45 publications

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“…Although Oyama et al [18] noted that the biological activities of the two compounds appear to differ depending on the cancer cell line, our results were consistent with other previous reports. [7,10] As Epifano et al [5] pointed out, previous studies reported only cytotoxic effects.…”

Section: Cell Growth Inhibition Effectsmentioning

confidence: 97%

“…(Rutaceae) is a small evergreen plant widely distributed from East Asia to South Asia, including South China, India, Sri Lanka and Indonesia. Extracts of the leaves, bark, stems and fruits of this plant are widely used in folk medicine to treat scabies, sores and ulcers, [5] and are reported to have antimicrobial activity, [6] cytotoxicity [7][8][9][10] and antioxidant capacity. [11] Various compounds have been isolated and identified from A. pedunculata, including quinolone alkaloids [12] and phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

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Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells

Matsui

Ito

Kato

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives We investigated the apoptotic activities of acrofolione A (1) and B (2) isolated from Acronychia pedunculata against a human pre‐B cell leukaemia cell line (NALM‐6) to explore the apoptosis‐related signalling molecules targeted by 1 and 2. Methods The apoptosis effects of 1 and 2 in NALM‐6 cells were investigated by TUNEL staining, annexin V, mitochondria membrane potential and caspase 3/7 activity. We carried out a protein array to explore the signalling molecules involved in apoptosis comprehensively. Key findings Acrofolione A (1) suppressed the growth of NALM‐6, K562 and HPB‐ALL cells (IC50 16.7 ± 1.9, 17.9 ± 0.3 and 10.1 ± 0.2 μm, respectively) more effectively than acrofolione B (2). Both compounds time‐dependently increased the number of NALM‐6 cells with abnormal nuclei, and increased the number of annexin V‐positive cells and decreased the mitochondrial membrane potential of NALM‐6 cells. Acrofolione A (1) markedly elevated caspase 3/7 activity and increased the number of TUNEL‐positive cells. Cells treated with either compound showed enhanced expression of cleaved PARP and cleaved caspase 3 and 7, and reduced survivin protein levels. Conclusions Acrofolione A (1) and B (2) may be useful in the treatment of various types of leukaemia.

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Section: Cell Growth Inhibition Effectsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells

Matsui

Ito

Kato

et al. 2019

Journal of Pharmacy and Pharmacology

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“…It produces quinoline alkaloids such as quinine, quinidine, cinchonine (3) Lemon aspen (Acronychia acidula) and several other species of Acronychia produce quinoline (acridone) alkaloids such acronycine, melicopine, melicopidine and acronycidine (Table 1) (10). From the same plant family, several species of Sarcomelicope also produce acronycine and other quinoline alkaloids (11 (15).…”

Section: Alkaloids In Woody Plantsmentioning

confidence: 99%

Distribution of alkaloids in woody plants

Desgagné‐Penix

2017

Plant Sci. Today

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Alkaloids are nitrogen-containing compounds found in plants. Most are highly valued for their role in wide array of ailments such as anti-malarial, anti-cancerous, analgesics, and many more. In lights of tremendous interest in recent years on the chemistry and pharmacological properties of alkaloids, comprehensive data have been collected. Forest industries have recently started to develop sustainable ways to increase the value of its residues including the extraction and commercialization of high-valued plant natural compounds such as alkaloids. This review presents the distribution of alkaloids among woody plants (trees and shrubs).

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“…Also, 2-phenylquinoline, present in the bark of some tropical trees, is useful in the treatment of parasitic diseases [13]. In general, quinoline and isoquinoline derivatives have been reported to be present in some medicinal plants [14] and essential oils [15]. From plants, quinolines may be transferred to honey and might therefore be useful for botanic and/or geographic origin classification purposes.…”

Section: Introductionmentioning

confidence: 99%

Time-of-flight accurate mass spectrometry identification of quinoline alkaloids in honey

et al. 2015

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Time-of-flight accurate mass spectrometry (TOF-MS), following a previous chromatographic (gas or liquid chromatography) separation step, is applied to the identification and structural elucidation of quinoline-like alkaloids in honey. Both electron ionization (EI) MS and positive electrospray (ESI+) MS spectra afforded the molecular ions (M(.+) and M+H(+), respectively) of target compounds with mass errors below 5 mDa. Scan EI-MS and product ion scan ESI-MS/MS spectra permitted confirmation of the existence of a quinoline ring in the structures of the candidate compounds. Also, the observed fragmentation patterns were useful to discriminate between quinoline derivatives having the same empirical formula but different functionalities, such as aldoximes and amides. In the particular case of phenylquinolines, ESI-MS/MS spectra provided valuable clues regarding the position of the phenyl moiety attached to the quinoline ring. The aforementioned spectral information, combined with retention times matching, led to the identification of quinoline and five quinoline derivatives, substituted at carbon number 4, in honey samples. An isomer of phenyquinoline was also noticed; however, its exact structure could not be established. Liquid-liquid microextraction and gas chromatography (GC) TOF-MS were applied to the screening of the aforementioned compounds in a total of 62 honeys. Species displaying higher occurrence frequencies were 4-quinolinecarbonitrile, 4-quinolinecarboxaldehyde, 4-quinolinealdoxime, and the phenylquinoline isomer. The Pearson test revealed strong correlations among the first three compounds.

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Phytochemistry and pharmacognosy of the genus Acronychia

Cited by 31 publications

References 45 publications

Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells

Acrofolione A and B, acetophenone dimers from Acronychia pendunculata, induce an apoptotic effect on human NALM-6 pre-B cell leukaemia cells

Distribution of alkaloids in woody plants

Time-of-flight accurate mass spectrometry identification of quinoline alkaloids in honey

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