Phytochemistry and pharmacological compounds present in scent leaf: A review

Edo, Great Iruoghene; Samuel, Princess Oghenekeno; Ossai, Samuel; Nwachukwu, Susan Chinedu; Okolie, Michael Chukwuma; Oghenegueke, Ogheneochuko; Akpoghelie, Patrick Othuke; Ugbune, Ufuoma; Ezekiel, Gracious Okeoghene; Onoharigho, Favour Ogheneoruese; Agbo, Joy Johnson

doi:10.1016/j.focha.2023.100300

Cited by 28 publications

(3 citation statements)

References 108 publications

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“…Flavonoid has been reported as the bioactive compounds known for their antimicrobial, anti‐inflammatory, and antioxidant properties (Edo et al., 2023). TFC was determined from the calibration curve using catechin as the standard.…”

Section: Resultsmentioning

confidence: 99%

Profiling of phenolic compounds, antimicrobial, antioxidant, and hemolytic activity of mango seed kernel using different optimized extraction systems

Saleem,

Hayat,

Tariq

et al. 2023

Journal of Food Science

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Mango seed kernels (MSKs) have been reported to show antioxidant, antibacterial, and anti‐inflammatory properties. This study explores the influence of different optimized extraction systems on the extraction of MSK. The effects on gallic acid (GA) content, total phenolic content (TPC), total flavonoid content (TFC), antioxidant, antimicrobial, and hemolytic activity of MSK extracts from different extraction systems (65.45% ethanol‐ultrasound assisted extraction [UAE], 62% ethanol‐incubator shaker, 19.4% ethanol‐UAE, and 100% water‐UAE) were assessed. Based on the results, a nonsignificant difference in phenolic (p = 0.222), flavonoids (p = 0.058), antioxidant (p = 0.165), and antimicrobial activity (p = 0.193) against Staphylococcus aureus whereas a significant difference (p < 0.0001) in hemolytic, GA content, and antimicrobial activity against Clostridium perfringens was observed. Among different extraction systems, aqueous extraction showed significantly lower hemolytic (1.09%) and higher GA content (4.72 mg/g) and comparable results in all other experiments; yield (32.40%), TPC (58.79 mg/g), TFC (2.16 mg/g), and antioxidant (73.19%). Hence, it has been concluded that aqueous extraction system could be considered a sustainable extraction system for practical applications.Practical ApplicationAqueous extraction system could be a sustainable option for extraction of mango seed kernel for practical applications as it is readily available, cheap, nonflammable, and nontoxic.

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Section: Resultsmentioning

confidence: 99%

Profiling of phenolic compounds, antimicrobial, antioxidant, and hemolytic activity of mango seed kernel using different optimized extraction systems

Saleem,

Hayat,

Tariq

et al. 2023

Journal of Food Science

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“…Aside from its culinary applications, O. basilicum possesses several potential health benefits due to its phytochemical composition. It contains essential oils, flavonoids, and phenolic compounds, contributing to its antioxidant and anti-inflammatory properties [16][17][18][19][20]. These bioactive compounds have been associated with potential neuroprotective, hepatoprotective, antimicrobial, and immunomodulatory effects.…”

Section: Introductionmentioning

confidence: 99%

Computational Studies to Understand the Neuroprotective Mechanism of Action Basil Compounds

Singh,

Mujwar,

Singh

et al. 2023

Molecules

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Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, pose a significant global health challenge, emphasizing the need for novel neuroprotective agents. Basil (Ocimum spp.) has been recognized for its therapeutic potential, and numerous studies have reported neuroprotective effects. In this manuscript, we present a computational protocol to extricate the underlying mechanism of action of basil compounds in neuroprotective effects. Molecular docking-based investigation of the chemical interactions between selected bioactive compounds from basil and key neuroprotective targets, including AChE, GSK3β, γ-secretase, and sirtuin2. Our results demonstrate that basil compound myricerone caffeoyl ester possesses a high affinity of −10.01 and −8.85 kcal/mol against GSK3β and γ-secretase, respectively, indicating their potential in modulating various neurobiological processes. Additionally, molecular dynamics simulations were performed to explore the protein–ligand complexes’ stability and to analyze the bound basil compounds’ dynamic behavior. This comprehensive computational investigation enlightens the putative mechanistic basis for the neuroprotective effects of basil compounds, providing a rationale for their therapeutic use in neurodegenerative disorders after further experimental validation.

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“…These traditional systems of medicine are widely used in developing countries where over 80% of the population solely depends on traditional medicine or folk remedies for primary healthcare need (Tugume and Nyakoojo, 2019). In recent years, several plants have demonstrated high level of potency against seizures/convulsions; and results from the phytochemical and pharmacological studies reviewed that it is due to the presence of bioactive compounds such as avonoids and other phenolics that have similar mechanism of action as their synthetic counterparts (Edo et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

An investigation of the phytochemical richness of fresh Musa paradisiaca L. (plantain) stem juice and its anticonvulsant potential on pentylenetetrazole (PTZ)-challenged rats

Ugwuoke,

Nwanelo,

Dawoye

et al. 2023

Preprint

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This study was aimed at determining the therapeutic value of fresh Musa paradisiaca L. (MP) stem juice as a potential treatment for epileptic convulsions using a pentylenetetrazole (PTZ)-induced seizure model in rats. Six groups of albino rats (n = 4) were involved in the study. Group I was treated with normal saline (p.o), while group II was untreated and group III received diazepam (4 mg/kg, p.o). Group IV, V and VI received 50, 75 and 100% v/v oral dose of MP stem juice, respectively). The treatment lasted for 10 days, followed by PTZ (85 mg/kg b.w, i.p) administration 60 min later. Lethality test and phytochemical screening were conducted. The rats were closely watched and meticulously monitored for seizure manifestations/episodes with the aid of a stop watch. From the results, the MP stem juice up to 100% (v/v) was safe in mice and numerous bioactive compounds were found with phenols being the most abundant (9.46 ± 0.03 mg/g), followed by alkaloids (5.54 ± 0.98 mg/g) and flavonoids (4.27 ± 1.23 mg/g). For the seizure manifestation, three intermittent seizures (episodes 1, 2 and 3) were observed and the stem juice (75 and 100% v/v) significantly (p < 0.05) increased the latency periods of episode 1 tonic and clonic seizures. The stem juice at 50% (v/v) delayed the onset of episode 2 seizures for over 10 minutes more than the untreated group. The groups that received 75 and 100% (v/v) of the stem juice did not experience seizures during the episode 2 as seen in episode 1. The standard and the test groups did not experience seizure during the episode 3. The findings of this study have demonstrated that the fresh MP stem juice could prevent convulsions by increasing the latencies and decreasing relatively the durations of seizures in PTZ-challenged rats. This study, however, provides the pharmacological evidence for the folk claim behind the use of Musa paradisiaca stem juice to manage epileptic convulsions or seizure disorders.

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Phytochemistry and pharmacological compounds present in scent leaf: A review

Cited by 28 publications

References 108 publications

Profiling of phenolic compounds, antimicrobial, antioxidant, and hemolytic activity of mango seed kernel using different optimized extraction systems

Profiling of phenolic compounds, antimicrobial, antioxidant, and hemolytic activity of mango seed kernel using different optimized extraction systems

Computational Studies to Understand the Neuroprotective Mechanism of Action Basil Compounds

An investigation of the phytochemical richness of fresh Musa paradisiaca L. (plantain) stem juice and its anticonvulsant potential on pentylenetetrazole (PTZ)-challenged rats

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