Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review

Abstract

Plumbago zeylanica L. (Plumbaginaceae) commonly known, as chitrak is pharmacologically important plant. Various studies have been undertaken to assess the pharmacological potential of different parts of the plant namely like roots, stem, flower, and leaves as antimicrobial, hepatoprotective, anticancer, antifertility, antiulcer, antifungal and wound healing. The intention of the present review is to deliver a concise account on its ethnobotanical uses, phytochemistry with an in-depth study of its phytoconstituents, facts and prospects of its potential pharmacological activities of this golden plant. An extensive literature survey was undertaken through different online platforms viz. Google Scholar and online databases namely PubMed, Science Direct and Springer. All papers based on traditional medicinal uses and pharmacological properties were included. Sixty three research articles and review articles were found to be apt for inclusion into the review. About 150 articles were retrieved for the purpose. The elaborative results vindicated that Plumbago zeylanica L. holds significant prospects in major health conditions such as diabetes, cardiovascular disorders, ulcer, liver problems, obesity, wound healing, cancer etc.

Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin

“…PLIHZ is a synthetic naphthoquinone derived from the combination of the natural phytochemical agent, plumbagin, and the anti-tuberculosis agent, isonicotinic hydrazid (INH) [ 25 ]. Plumbagin is isolated from the roots of the medicinal plant Plumbago zeylanica and has been suggested as an anti-cancer, anti-inflammatory, and cytotoxic agent [ 26 , 37 ]. Plumbagin shows its anti-tumor effects through induction of cell cycle arrest, apoptosis, and autophagy, as well as inhibition of EMT by inhibition of Akt signaling, activation of wtp53, inhibition of NF-kB activity, and other unknown mechanisms, in multiple types of cancer [ 22 , 26 , 27 , 28 ].…”

Fractions of Aqueous Extract of Plumbago zeylanica (L.) Root Induced Mitochondrial Membrane Permeability Transition Pore Opening in Rats

“…Plumbago zeylanica L., is an abundantly branched perennial herb with alternate leaves [12]. It is an annual plant that can grow up to the height of 3-4 ft. Leaves are thick, fleshy, sessile, oval, and lance-elliptic in shape.…”

“…Different parts of P. zeylanica L. have been utilized for centuries for various medicinal purposes. The root and root bark of the plant has been utilized in the preparation of varied ayurvedic medicines [12]. In ethnomedicine, it has been indicated for its significant protective role in enlarged liver and spleen [12].…”

“…The root and root bark of the plant has been utilized in the preparation of varied ayurvedic medicines [12]. In ethnomedicine, it has been indicated for its significant protective role in enlarged liver and spleen [12]. It is a bitter tonic and suggested as a rejuvenator, well known for its use in chronic colds and cough.…”

“…Extracts of P. zeylanica are reported as anticancer drugs. Root bark is additionally considered beneficial in obesity [12]. Notably, extracts of P. zeylanica and certain phytochemicals isolated from the plant has been reported to have an apoptotic effect [13].…”