Phytochemistry, Antinociceptive and Anti-inflammatory Actvities of Methanolic Leaves Extract of Lannea schimperi (Hoschst. Ex Rich) ENG.

Egbe, Emmanuel O.; Akumka, David D.; Mohammed, Adamu; Mikail, Hudu Garba

doi:10.2174/187220830902160308195034

Cited by 7 publications

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“…Pharmacological studies on L. schimperi bark, leaf, root, and stem extracts exhibited potent in vitro and in vivo pharmacological activities including anesthetic [79], antibacterial [79,86], antifungal [86,87], anticoccidial [88], anti-inflammatory [82], antinoceceptive [82], antioxidant [83], anti-trypanosomal [89], antiulcerogenic [79], cytotoxicity [77,79,81,90], and toxicity [8,79] activities.…”

Section: Pharmacological Properties Of L Schimperimentioning

confidence: 99%

“…Egbe et al [82] evaluated the anti-inflammatory activities of the methanolic leaf extracts of L. schimperi at doses of 12 mg/kg and 24 mg/kg using the egg albumin-induced acute inflammation model in rat with aspirin at dose of 80 mg/kg used as a positive control while the drug vehicle was used as a negative control. The extracts showed activities at both doses, and there were no significant differences between the extract treated rats with those rats treated with the standard drug, aspirin [82]. The exhibited anti-inflammatory activities of the methanolic leaf extracts of L. schimperi could be beneficial in alleviating painful inflammatory conditions.…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

“…Egbe et al [82] evaluated the antinociceptive activities of the methanolic leaf extracts of L. schimperi at doses of 12 mg/kg and 24 mg/kg using acetic acid-induced writhing model in mice with aspirin at dose of 80 mg/kg used as a positive control while the drug vehicle was used as a negative control. The extracts showed activities at both doses, decreasing the acetic -nduced writhing reflex in mice when compared with the negative control [82].…”

Section: Antinociceptive Activitiesmentioning

confidence: 99%

“…Bark.Maroyiand sitosterol from the root and stem bark extracts, respectively, of L. schimperi(Table 2). Other phytochemical compounds that have been identified from the stem bark and gum exudates of L. schimperi include alkaloids, anthocyanins, anthracene glycosides, carbohydrates, cardiac glycosides, carotenoids, condensed tannins, coumarins, flavonoids, phenolic glycosides, phenols, polyoses, polyuronoids, reducing sugars, saponins, steroids, tannins, triterpenoids, and volatile compounds[12,79,82,83] (…”

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Lannea Schimperi: Review of Its Botany, Medicinal Uses, Phytochemistry, and Biological Activities

Maroyi

2019

Asian J Pharm Clin Res

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Lannea schimperi is a well-known fruit tree and medicinal plant in tropical Africa. The current study critically reviewed the botany, medicinal uses, phytochemistry, and pharmacological activities of L. schimperi. Literature on botany, medicinal uses, phytochemical and biological activities of L. schimperi were collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, PubMed, BMC, ScienceDirect, and Scopus. Complementary information was gathered from pre-electronic sources such as books, book chapters, theses, scientific reports, and journal articles obtained from the University Library. This study revealed that the species is used as a source of fiber, edible fruits, and herbal medicine. Phytochemical compounds identified from the species include cyclohexenones, cardanols, alkaloids, anthocyanins, anthracene glycosides, carbohydrates, cardiac glycosides, carotenoids, condensed tannins, coumarins, flavonoids, phenolic glycosides, phenols, polyoses, polyuronoids, reducing sugars, saponins, steroids, tannins, triterpenoids, and volatile compounds. Pharmacological research revealed that extracts and phytochemical constituents isolated from L. schimperi have anesthetic, antibacterial, antifungal, anticoccidial, anti-inflammatory, antinociceptive, antioxidant, anti-trypanosoma, antiulcerogenic, cytotoxicity, and toxicity activities. L. schimperi should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities of the species.

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Section: Pharmacological Properties Of L Schimperimentioning

confidence: 99%

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

Section: Antinociceptive Activitiesmentioning

confidence: 99%

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Lannea Schimperi: Review of Its Botany, Medicinal Uses, Phytochemistry, and Biological Activities

Maroyi

2019

Asian J Pharm Clin Res

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“…against various diseases. It has been shown that twigs induce apoptosis of human liver cancer cells [14] and leaves have antinociceptive [15], antioxidant [16], and antidiarrheal [17] activities. Barks were found to have anti-inflammatory [18], hypotensive [19], antihyperglycaemic [9], antimicrobial, antifungal [7], analgesic, and antioxidant effects [20], and the bark showed zoosporicidal activity [21].…”

Section: Introductionmentioning

confidence: 99%

Lannea coromandelica (Houtt.) Merr. Induces Heme Oxygenase 1 (HO-1) Expression and Reduces Oxidative Stress via the p38/c-Jun N-Terminal Kinase–Nuclear Factor Erythroid 2-Related Factor 2 (p38/JNK–NRF2)-Mediated Antioxidant Pathway

Alam

Kwon

Lee

et al. 2017

IJMS

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The leaves of Lannea coromandelica (Houtt.) Merr. are used in the Garo, Pahan, and Teli tribal communities of Bangladesh as a traditional medicinal plant to treat hepatitis, diabetes, ulcers, heart disease, and dysentery. However, there have been limited phytochemical and biological studies on the bark of L. coromandelica. This study aimed to investigate the antioxidant activities of L. coromandelica bark extract (LCBE) and the underlying mechanism using RAW 264.7 cells. The LCBE was analysed by high-pressure liquid chromatography (HPLC) to detect its key polyphenolic compounds. Various in vitro antioxidant assays were performed using RAW 264.7 cells to assess the antioxidant effects of the LCBE and to understand the underlying molecular mechanism. HPLC revealed the presence of gallic acid, (−)-epigallocatechin-3-gallate, catechin, chlorogenic acid, and caffeic acid in the LCBE. The extract showed a very potent capacity to scavenge numerous free radicals through hydrogen atom transfer and/or electron donation and also quenched cellular reactive oxygen species (ROS) generation without showing any toxicity. The LCBE was found to combat the oxidative stress by enhancing the expression, at both transcriptional and translational levels, of primary antioxidant enzymes as well as phase II detoxifying enzymes, especially heme oxygenase 1, through the upregulation of the nuclear factor erythroid 2-related factor 2 (NRF2)-mediated pathway in RAW 264.7 cells via the phosphorylation of p38 kinase and c-Jun N-terminal kinase (JNK). The LCBE exhibited strong antioxidant activities and mitigated the cellular ROS production. These results provide scientific evidence of its potential as an ideal applicant for a cost-effective, readily available, and natural phytochemical, as well as a strategy for preventing diseases associated with oxidative stress and attenuating disease progress.

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Anti-inflammatory activity of β-patchoulene isolated from patchouli oil in mice

Zhang

Chen

et al. 2016

European Journal of Pharmacology

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β-Patchoulene (β-PAE) is a tricyclic sesquiterpene isolated from the oil of Pogostemon cablin (patchouli oil), which has been widely used in traditional Chinese medicine for the treatment of inflammatory diseases. However, as one of the major principle of patchouli oil, the biological activity of β-PAE has not been explored so far. In the present study, the anti-inflammatory activity in vivo, and the underlying mechanism, of β-PAE was investigated on experimental mice models of acute inflammation, i.e. xylene-induced ear edema, acetic acid-induced vascular permeability and carrageenan-induced paw edema. The results showed that β-PAE evoked a significant dose-dependent inhibition of ear edema induced by xylene, paw edema induced by carrageenan and suppressed the increase of vascular permeability elicited by acetic acid. Histopathological analysis indicated that β-PAE could markedly decrease the cellular infiltration in paw tissue. β-PAE was also shown to significantly decrease the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in edema paw. In addition, carrageenan-induced production of some pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), prostaglandin E2 (PGE2) and nitric oxide (NO), were suppressed in a dose-dependent manner in mice subjected to β-PAE pretreatment, and it also significantly down-regulated the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Further analysis revealed that β-PAE also inhibited the translocation of nuclear factor-κB (NF-κB) from the cytoplasm to the nucleus and stabilize the conversion of nuclear factor-κBα (IκBα) level. These results provided additional chemical and pharmacological basis for the traditional application of P. cablin in inflammatory disorders.

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Phytochemistry, Antinociceptive and Anti-inflammatory Actvities of Methanolic Leaves Extract of Lannea schimperi (Hoschst. Ex Rich) ENG.

Abstract: The patent data revealed the antinociceptive and anti-inflammatory potentials of the methanolic leaves extract of Lannea schimperi which could be beneficial in alleviating painful inflammatory conditions.

Cited by 7 publications

References 0 publications

Lannea Schimperi: Review of Its Botany, Medicinal Uses, Phytochemistry, and Biological Activities

Lannea Schimperi: Review of Its Botany, Medicinal Uses, Phytochemistry, and Biological Activities

Lannea coromandelica (Houtt.) Merr. Induces Heme Oxygenase 1 (HO-1) Expression and Reduces Oxidative Stress via the p38/c-Jun N-Terminal Kinase–Nuclear Factor Erythroid 2-Related Factor 2 (p38/JNK–NRF2)-Mediated Antioxidant Pathway

Anti-inflammatory activity of β-patchoulene isolated from patchouli oil in mice

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