Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L.

Asgarpanah, Jinous; Kazemivash, Nastaran

doi:10.5897/ajpp12.901

Cited by 52 publications

(49 citation statements)

References 34 publications

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“…It is very important to underline that the use of plants and other botanical preparations are used, since ancient times, by primitive societies, due to healing properties and therapeutic and psychotherapeutic benefits. It is important to address the fact that plants are widely used to obtain a large variety of drugs, being used in folk medicine for a long time [26][27][28][29][32][33][34][35]. Concerning that plants represent an economic, easily and which are accessible for all of people, they can be used into a variety of diseases, constituting an excellent source of biomolecules able to act like natural antifungal agents and, at the same time, to encourage the search for other alternative treatments.…”

Section: Therapeutic Approachmentioning

confidence: 99%

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

et al. 2014

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SUMMARYCandidiasis is the most common opportunistic yeast infection. Candida species and other microorganisms are involved in this complicated fungal infection, but Candida albicans continues to be the most prevalent. In the past two decades, it has been observed an abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infections and even in healthy individuals. There is a widely variety of causal factors that contribute to yeast infection which means that candidiasis is a good example of a multifactorial syndrome. Due to rapid increase in the incidence of these infections, this is the subject of numerous studies. Recently, the focus of attention is the treatment and, above all, the prevention of those complications. The diagnosis of candidiasis could become quite complicated. Prevention is the most effective "treatment", much more than eradication of the yeast with antifungal agents. There are several aspects to consider in the daily routine that can provide a strength protection. However, a therapeutic approach is necessary when the infection is established and, therefore, other alternatives should be explored. This review provides an overview on predisposition factors, prevention and diagnosis of candidiasis, highlighting alternative approaches for candidiasis treatment.

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Section: Therapeutic Approachmentioning

confidence: 99%

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

et al. 2014

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“…Future studies will be necessary to expand the existing, limited therapeutic drugs for the vast majority of liver diseases. Reports of medicinal plants for the treatment of liver disease are numerous; however, due to space limitations, we will focus on only a few (Ansari et al, 2011;Asgarpanah & Kazemivash, 2012;Asuku et al, 2012;Avila et al, 2011;Ghosh et al, 2011;Gutierrez et al, 2013;Haddad et al, 2011;Ho et al, 2012;Lee et al, 2012;Mihailovic et al, 2013;Nagalekshmi et al, 2011;Nithianantham et al, 2011;Paul et al, 2013;Shivananjappa et al, 2013;Singab et al, 2010;Mukherjee et al, 2009;Rana et al, 2011;Subramanian et al, 2012;Torres-Gonalez et al, 2011;Upadhyay et al, 2013;Xavier et al, 2012;Zhang et al, 2012).…”

Section: Scientific Rationale For the Traditional Use Of Some Plants mentioning

confidence: 99%

Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms

Farghali

Canová

Zakhari³

2014

Pharmaceutical Biology

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Context: We focused on certain plant active constituents considered to be the most promising/ studied for liver disease and that were critically investigated from the basic science point of view and, to some extent, the clinical one. Due to insufficient pharmacological data, most of the herbal formulations containing these molecules cannot be recommended for the treatment of liver disease. Objective: To present the most promising compounds tested experimentally and/or clinically and describe in brief popular models in experimental testing of potential hepatoprotective compounds. Methods: A literature search using Web of Science (WOS), PubMed, and Google search was performed.Results: Focusing on a few herbal hepatoprotective active constituents is useful to health professionals working in the field of therapeutics to develop evidence-based hepatoprotective agents by conducting research on pure chemical structures or on molecular modifications using computational chemistry. This review demonstrates that multi-pathways in the liver pathobiology can be interrupted at one or more levels by natural hepatoprotective studied, such as interference with the oxidative stress at multiple levels to reduce reactive oxygen/ nitrogen species, resulting in ameliorating hepatotoxicity. Conclusion: Hepatoprotective constituents of herbal medications are poorly absorbed after oral administration; methods that can improve their bioavailability are being developed. It is recommended that controlled prospective double-blind multicenter studies on isolated active plant constituents, or on related newly designed molecules after structural modifications, should be performed. This effort will lead to expanding the existing, limited drugs for the vast majority of liver diseases.

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“…Various polyphenol and flavonoid compounds, including glycitin, caffeic acid, protocatechuic acid, apigenin, Aliphatic (2E)-alkenals, and alkanals were reported in the aerial parts of C. sativum (21-23) whereas, Quercetin 3-glucuronide, isoquercitrin, and rutin were found in the fruit (24). Recently, several novel phytochemical and pharmacological studies have been performed on C. sativum and results have been reported in review articles (20,25). However, studies have always focused on the roots and aerial parts of C. sativum for their antioxidant properties (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, all parts of the plant are used to alleviate gastrointestinal complaints, bronchitis, muscular spasm, gout, and rheumatoid disorders (16). Several studies performed on this herb reported that the plant has various therapeutic properties, including, anti-microbial, anti-hyperlipidemia, hepato-protective, anti-peroxidative, insulin-releasing, and insulin-like activity (17)(18)(19)(20). Various polyphenol and flavonoid compounds, including glycitin, caffeic acid, protocatechuic acid, apigenin, Aliphatic (2E)-alkenals, and alkanals were reported in the aerial parts of C. sativum (21-23) whereas, Quercetin 3-glucuronide, isoquercitrin, and rutin were found in the fruit (24).…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

Talaei

Kheirollah

Babaahmadi‐Rezaei

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Development of a new iron-chelating medication may eventually serve as treatment of iron overload diseases, such as thalassemia and other iron related disorders. Coriander sativum, a plant rich of phenol and flavonoids, has an iron-chelating effect in-vitro. The ethanolic extract of C. sativum was investigated for its in-vivo ameliorating effect on hepatic damage in rats with experimental iron overload. Methods: Twenty-four adult male wistar rats were randomly divided to 4 groups: healthy control, iron overload, iron overload treated with deferoxamine, and 200 mg/kg of C. sativum extract, respectively. Assessments were performed for serum iron, ferritin, and serum markers of hepatic and cardiac damages, antioxidant enzyme, and lipid peroxidation levels. Results:The results indicated serum iron and ferritin concentration were significantly increased in the iron overload group compared to healthy controls (P < 0.05). Treatment with C. sativum extract significantly decreased iron and ferritin concentration (P < 0.05). Histopathological changes in the liver, kidney, and the cardiac system, and iron accumulation in the liver were observed in the iron overload group compared to healthy controls (P < 0.05). Treatment with C. sativum extract significantly decreased biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and Creatinine phosphokinase (CPK), and improved tissue damage and decreased iron accumulation in the liver compared to the iron overload group (P < 0.05). Conclusions:The study showed that the hydro-alcoholic extract of C. sativum has iron-chelating and liver protective effects similar to deferoxamine against experimental iron overload condition in rats.

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Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L.

Cited by 52 publications

References 34 publications

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

Hepatoprotective properties of extensively studied medicinal plant active constituents: Possible common mechanisms

The Protective Effects of Hydro-Alcoholic Extract of Coriandrum sativum in Rats with Experimental Iron-Overload Condition

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