Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review

Dhatwalia, Jyoti; Kumari, Amita; Verma, Rachna; Upadhyay, Navneet Kumar; Guleria, Ishita; Lal, Sohan; Thakur, Shabnam; Gudeta, Kasahun; Kumar, Vikas; Chao, Jane C.-J.; Sharma, Somesh; Kumar, Ashwani; Manicum, Amanda-Lee E.; Lorenzo, José M.; Amarowicz, Ryszard

doi:10.3390/molecules26227010

Cited by 30 publications

(20 citation statements)

References 87 publications

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“…The lower value of IC 50 indicates a higher antioxidant potential [ 50 ]. In DPPH, ABTS, and FRAP assays, ascorbic acid showed the lower IC 50 followed by fruit extract and ZnO-NPs ( Figure 8 ).…”

Section: Resultsmentioning

confidence: 99%

Rubus ellipticus Sm. Fruit Extract Mediated Zinc Oxide Nanoparticles: A Green Approach for Dye Degradation and Biomedical Applications

et al. 2022

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Rubus ellipticus fruits aqueous extract derived ZnO-nanoparticles (NPs) were synthesized through a green synthesis method. The structural, optical, and morphological properties of ZnO-NPs were investigated using XRD, FTIR, UV-vis spectrophotometer, XPS, FESEM, and TEM. The Rietveld refinement confirmed the phase purity of ZnO-NPs with hexagonal wurtzite crystalline structure and p-63-mc space group with an average crystallite size of 20 nm. XPS revealed the presence of an oxygen chemisorbed species on the surface of ZnO-NPs. In addition, the nanoparticles exhibited significant in vitro antioxidant activity due to the attachment of the hydroxyl group of the phenols on the surface of the nanoparticles. Among all microbial strains, nanoparticles’ maximum antibacterial and antifungal activity in terms of MIC was observed against Bacillus subtilis (31.2 µg/mL) and Rosellinia necatrix (15.62 µg/mL), respectively. The anticancer activity revealed 52.41% of A549 cells death (IC50: 158.1 ± 1.14 µg/mL) at 200 μg/mL concentration of nanoparticles, whereas photocatalytic activity showed about 17.5% degradation of the methylene blue within 60 min, with a final dye degradation efficiency of 72.7%. All these results suggest the medicinal potential of the synthesized ZnO-NPs and therefore can be recommended for use in wastewater treatment and medicinal purposes by pharmacological industries.

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Section: Resultsmentioning

confidence: 99%

Rubus ellipticus Sm. Fruit Extract Mediated Zinc Oxide Nanoparticles: A Green Approach for Dye Degradation and Biomedical Applications

et al. 2022

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“…Broad ethnobotanical studies and anthropological research would help to situate this healing focus in the context of the wider value of biodiversity as integral to existence in communities of the Global South [19]. Previous articles reviewing C. spinarum have examined the phytochemistry and pharmacology of the species with limited attention to the wider ethnobiology of this species [20][21][22][23][24][25][26]. The scope of this chapter is to:…”

Section: Introductionmentioning

confidence: 99%

Carissa spinarumL.: A Case Study in Ethnobotany and Bioprospecting Research

Smyth¹,

Sheridan²

2022

Medicinal Plants

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This study explores ethnobiological and bioprospecting research through the lens of Carissa Spinarum L., using it as a case study to examine wider trends in such research. Hunn’s Phasing in Ethnobiology is used as a framework, analysing the extensive research of a species used in healing, diet and other domains. Most reported studies are illustrative of Phase I Ethnobiological research based on the lack of basic context, emic or ecological detail, or a sense of collaboration with participants or across disciplines. Elements of Phases II, III and IV are evident in some studies highlighting ethnographic context, ecological issues or indigenous knowledge and rights. The extractive character of Phase I research, usually used for bioprospecting purposes, decontextualises plant use and may contribute to the historically poor results from ethno-directed bioprospecting. The widespread marginalisation of the social sciences in bioprospecting research can invalidate the whole research project and in turn ethnomedical plant use itself. A species such as Carissa Spinarum L., emerging from Phase I research, can become a mere collection of its phytochemical parts, invalidated if those parts do not meet scientific measures of value. The collaborative character of Phase IV and V Ethnobiology would reward with more ethical and effective research with healing plants.

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“…Phytochemistry, pharmacology, and the nutraceutical profile of the Carissa species is also described in this Special Issue [ 10 ]. Carissa is a genus of shrubs or small trees native to tropical and subtropical regions of Africa, Australia and Asia.…”

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confidence: 99%

“…A total of 121 compounds (35 polyphenols (flavonoids and phenolic acids), 30 lignans, 41 terpenoids, 7 steroids, 2 coumarins, and 6 cardiac glycosides) were extracted from C. spinarum, C. carandas , and C. macrocarpa . Among all chemical constituents, lupeol, carissol, naringin, carisssone, scopoletin, carissaeduloside A, D, J, carandinol, sarhamnoloside, carissanol, olivil, carinol, 3β-hydroxyolean-11-en-28,13β-oilde, ursolic acid, and carissone are the key bioactive constituents responsible for the pharmacological activities of genus Carissa [ 10 ].…”

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confidence: 99%