Phytochemistry, Pharmacology and Toxicity of Medicinal Plants

Tariq, Lubna; Bhat, Basharat Ahmad; Hamdani, Syed Suhail; Mir, Rakeeb Ahmad

doi:10.1007/978-3-030-58975-2_8

Cited by 15 publications

(5 citation statements)

References 111 publications

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“…As per the reports of the World Health Organization (WHO), human beings are paying most of their attention to the use of herbal medicines as they have the least side effects [ 90 , 91 ]. A huge number of medicinal plants are currently being investigated to explore natural products as the best alternative to unsafe drugs [ 92 , 93 , 94 ]. Regardless of the growth in recent diagnostics and treatment strategies, the prevalence of diseases at the global level is still rising.…”

Section: Role Of Saffron Bioactive Compounds Against Human Diseasesmentioning

confidence: 99%

Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities

Mir,

Tyagi,

Hussain

et al. 2024

Plants

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Plants are an important source of essential bioactive compounds that not only have a beneficial role in human health and nutrition but also act as drivers for shaping gut microbiome. However, the mechanism of their functional attributes is not fully understood despite their significance. One such important plant is Crocus sativus, also known as saffron, which possesses huge medicinal, nutritional, and industrial applications like food and cosmetics. The importance of this plant is grossly attributed to its incredible bioactive constituents such as crocins, crocetin, safranal, picrocrocin, and glycosides. These bioactive compounds possess a wide range of therapeutic activities against multiple human ailments. Since a huge number of studies have revealed negative unwanted side effects of modern-day drugs, the scientific communities at the global level are investigating a large number of medicinal plants to explore natural products as the best alternatives. Taken into consideration, the available research findings indicate that saffron has a huge scope to be further explored to establish alternative natural-product-based drugs for health benefits. In this review, we are providing an update on the role of bioactive compounds of saffron as therapeutic agents (human disorders and antimicrobial activity) and its nutritional values. We also highlighted the role of omics and metabolic engineering tools for increasing the content of key saffron bioactive molecules for its mass production. Finally, pre-clinical and clinical studies seem to be necessary to establish its therapeutic potential against human diseases.

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Section: Role Of Saffron Bioactive Compounds Against Human Diseasesmentioning

confidence: 99%

Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities

Mir,

Tyagi,

Hussain

et al. 2024

Plants

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“…AD causes neuroinflammatory reactions, mitochondrial malfunction, oxidative stress, loss of synaptic plasticity, transportation, and tau hyperphosphorylation, in addition to other associated cellular abnormalities. Aβ is produced as a predictable consequence of these physiological modifications ( Tariq et al, 2021 ). Numerous botanical herbs demonstrated anti-amyloidogenic properties, indicating its influences on the accumulation and instability of pre-existing Aβ fibrillary aggregates in the CNS ( Maccioni et al, 2010 ; Mir et al, 2021b ; Nomoto et al, 2021 ; Wainwright et al, 2022 ).…”

Section: Anti-amyloid Effectsmentioning

confidence: 99%

Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

et al. 2022

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The current scientific community is facing a daunting challenge to unravel reliable natural compounds with realistic potential to treat neurological disorders such as Alzheimer’s disease (AD). The reported compounds/drugs mostly synthetic deemed the reliability and therapeutic potential largely due to their complexity and off-target issues. The natural products from nutraceutical compounds emerge as viable preventive therapeutics to fill the huge gap in treating neurological disorders. Considering that Alzheimer’s disease is a multifactorial disease, natural compounds offer the advantage of a multitarget approach, tagging different molecular sites in the human brain, as compared with the single-target activity of most of the drugs so far used to treat Alzheimer’s disease. A wide range of plant extracts and phytochemicals reported to possess the therapeutic potential to Alzheimer’s disease includes curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, oleocanthal, and other phytochemicals such as huperzine A, limonoids, and azaphilones. Reported targets of these natural compounds include inhibition of acetylcholinesterase, amyloid senile plaques, oxidation products, inflammatory pathways, specific brain receptors, etc. We tenaciously aimed to review the in-depth potential of natural products and their therapeutic applications against Alzheimer’s disease, with a special focus on a diversity of medicinal plants and phytocompounds and their mechanism of action against Alzheimer’s disease pathologies. We strongly believe that the medicinal plants and phytoconstituents alone or in combination with other compounds would be effective treatments against Alzheimer’s disease with lesser side effects as compared to currently available treatments.

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“…Sir Samuel Hahnemann invented Homoeopathy Medical Science using the Essences of the active principle of singular plant. Substantial research works have been carried out in these directions [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Synergic Active Principles of Medicinal Plants in Complex Remedy Makes Electro-Homeopathy — A Novel Medical System

Taki,

Sarkar,

Saha

et al. 2024

JNR

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The traditional herbal remedy utilises the active principles of medicinal plants, either in singular or combination. Electro-homoeopathy uses the favourable component of the active principle or medicinal properties, removing the toxic part, and using various scientific processes to prepare the remedies. To achieve faster recovery of the affected organ, Count Cesar Mattei invented a Complex herbal remedy by the Synergic mixing of the Spagyric essence of selected plants. Mattei also mentioned that a suitable complex remedy could fully cover and control the complex remedy and the affected organ. In such a complex, the toxin is eliminated by thermal, various energy-driven scientific processes, enhancing medicinal properties. A table has been designed for 114 plants to correlate the active principles/medicinal properties of the parts used in various Electro-Homeopathy remedies. The uses of the complex remedy and the remarkable clinical results obtained by the inventor and his numerous followers have been referred to in their books and reports. The basic steps of the selection of remedies in the context of affected organs and diseases are presented in the tables. The underlying Alchemical Spagyric preparation method Cohobation has been precisely addressed here.

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Phytochemistry, Pharmacology and Toxicity of Medicinal Plants

Cited by 15 publications

References 111 publications

Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities

Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities

Natural Therapeutics in Aid of Treating Alzheimer’s Disease: A Green Gateway Toward Ending Quest for Treating Neurological Disorders

Synergic Active Principles of Medicinal Plants in Complex Remedy Makes Electro-Homeopathy — A Novel Medical System

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