Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum): A review

Baliga, Manjeshwar Shrinath; Bhat, Harshith P.; Baliga, Bantwal Raghavendra Vittaldas; Wilson, R.B.; Palatty, Princy Louis

doi:10.1016/j.foodres.2011.02.007

Cited by 152 publications

(105 citation statements)

References 67 publications

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“…The fruits of Syzygium sp. also exhibit various pharmacological activities such as antidiarrhoeal, antidiuretic properties, antihyperlipidaemic, anti-inflammatory, antimicrobial, antioxidant, antiscorbutic, antiulcerogenic, astringent, cardioprotective, hepatoprotective and stomachic properties (Baliga et al 2011;Bag et al 2012;Ramya et al 2012). The present study, in vivo experiment, was carried out with the ethanol fruit extract of S. densiflorum to evaluate the antidiabetic, antilipidaemic and antioxidant properties in STZ À NA-induced rats.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ À NAinduced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed.Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSDtreated groups (p50.001). Histopathological examination showed the regeneration of b-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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“…The best effect was observed at 80 mg/kg but only when administered through the intraperitoneal route as 50% of the animals survived when compare to 22% in the oral route and none in the radiation alone cohorts. The intraperitoneal administration of the organic extract (dichloromethane-methane) of leaves (5,10,20,30,40,50,60 and 80 mg/kg b. wt.)…”

Section: Radioprotective Effectsmentioning

confidence: 99%

Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses

Swami¹,

Thakor²,

Patil³

et al. 2012

FNS

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Eugenia jambolana Lam., commonly known as black plum or "jamun" is an important medicinal plant in various traditional systems of medicine. It is effective in the treatment of diabetes mellitus, inflammation, ulcers and diarrhea and preclinical studies have also shown it to possess chemopreventive, radioprotective and antineoplastic properties. The plant is rich in compounds containing anthocyanins, glucoside, ellagic acid, isoquercetin, kaemferol and myrecetin. The seeds are claimed to contain alkaloid, jambosine, and glycoside jambolin or antimellin, which halts the diastatic conversion of starch into sugar. The present review has been primed to describe the existing data on the information on traditional and medicinal use.

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“…Polyphenolic compounds, especially flavonoids have a number of beneficial effects on human health [59]. Several studies revealed that flavonoids are responsible for anticancer, anti-inflammatory, antiallergic, antibacterial, antifungal, antiviral and anti-diarrheal activities [60,61]. Flavonoids are markedly effective for controlling lipid peroxidation that lead to thrombosis, atherogenesis and carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

Mamun¹,

Khanum²,

Begum³

et al. 2016

J Coast Life Med

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Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum): A review

Cited by 152 publications

References 67 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

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Phytochemistry, traditional uses and pharmacology of Eugenia jambolana Lam. (black plum): A review

Cited by 152 publications

References 67 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Jamun (&lt;i&gt;Syzygium cumini &lt;/i&gt;(L.)): A Review of Its Food and Medicinal Uses

Analysis of in vitro antioxidant activity of Caryota urens L. leaves: A traditional natural remedy

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Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses