Phytoconsitutents As Bioenhancers: A Review

Abstract

Bio-enhancers are the compounds that enhance the bioavailability of active pharmaceutical ingredients without itself having any pharmacological action. Most of them are of natural origin and do not have any side effects. They enhance the bioavailability by influencing variety of mechanisms involved in the drug action like penetration enhancement, improving metabolism, enzyme inhibition, drug targeting etc. Use of these compounds help to reduce the dose frequency which in turn reduces drug retention in turn causing the toxicity and it also helps in developing cost-effective products. Present days these are widely used to enhance the bioavailability of anti-bacterial, anti-viral, antibiotic, anticancer, anti-inflammatory, cardiovascular drugs etc and effective drug targeting. The present review is designed to emphasize the importance of certain phytoconstituents working as bio-enhancers, their classification and different mechanisms of their activity.

Validated high‐performance thin layer chromatographic method for simultaneous quantification of rifampicin and quercetin in liquisolid formulation using fractional factorial design in robustness study

“…Moreover, significant concerns with therapy are extensive treatment time, helpless patient consistency, impedance in a safe framework, and lung tissue demolition [3][4][5]. To beat the above issues, Quercetin as a natural bioenhancer was combined with a fixed dose combination of Rifampicin and Quercetin with the focus of improving bioavailability and decreasing the unfavorable impact related to the current tuberculosis treatment [6,7]. Quercetin, a pentahydroxy flavone is a flavonoid glycoside found in natural citrus products and is also used as a nutritional supplement.…”

“…It has antioxidant potential and is used for alleviating symptoms of heart disease, cancer, degenerative brain disorder, diabetes, and allergy. It shows hostility toward oxidants, extremist searching, and calming against atherosclerotic exercises [6,7].…”