Phytoconstituents of Jatropha curcas L. Leaves and their Immunomodulatory Activity on Humoral and Cell-Mediated Immune Response in Chicks

Abd‐Alla, Howaida I.; Moharram, Fatma A.; Gaara, Ahmed H.; El-Safty, Mounir M.

doi:10.1515/znc-2009-7-805

Cited by 48 publications

(30 citation statements)

References 12 publications

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“…The characteristic UV spectra, their retention time and co-elution with authentication standard let us to identify compounds as vicenin-2 ( 1 ); stellarin-2 ( 2 ); vitexin ( 3 ); isovitexin ( 4 ); isorhoifolin ( 5 ); and rhoifolin ( 6 ). Several of these compounds have already been reported in other leaves of Jatropha curcas L. (although grown in conditions different from the one tested in our experiment) and Jatropha genus suggesting a common pattern of flavonoids that are conserved in the species and may represent an indication of the endogenous adaptation of the plant to Calabrian marginal areas [17,52,53,54,55,56,57,58]. …”

Section: Resultssupporting

confidence: 68%

Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Papalia

Barreca

Panuccio

2017

IJMS

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Jatropha (Jatropha curcas L.) is a plant native of Central and South America, but widely distributed in the wild or semi-cultivated areas in Africa, India, and South East Asia. Although studies are available in literature on the polyphenolic content and bioactivity of Jatropha curcas L., no information is currently available on plants grown in pedoclimatic and soil conditions different from the autochthon regions. The aim of the present work was to characterize the antioxidant system developed by the plant under a new growing condition and to evaluate the polyphenol amount in a methanolic extract of leaves. Along with these analyses we have also tested the antioxidant and cytoprotective activities on lymphocytes. RP-HPLC-DAD analysis of flavonoids revealed a chromatographic profile dominated by the presence of flavone C-glucosydes. Vitexin is the most abundant identified compound followed by vicenin-2, stellarin-2, rhoifolin, and traces of isovitexin and isorhoifolin. Methanolic extract had high scavenging activity in all antioxidant assays tested and cytoprotective activity on lymphocytes exposed to tertz-buthylhydroperoxide. The results highlighted a well-defined mechanism of adaptation of the plant and a significant content of secondary metabolites with antioxidant properties, which are of interest for their potential uses, especially as a rich source of biologically active products.

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Section: Resultssupporting

confidence: 68%

Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Papalia

Barreca

Panuccio

2017

IJMS

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“…41 This was in accordance with the increase of published papers about the antiviral and immunomodulatory activities of flavonoids in the last two decades. 2,49,50 Some of the isolated and identified compounds such as quercetin and kaempferol were previously mentioned in literature that they possess antiviral properties. 42 Other flavonoids for example; galangin, quercetin, procyanidin and pelargonidin as well as procyanidin C-1 are found to be with virucidal properties.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Immune Boosting Properties and Combating of Multiple Respiratory Viral Infections by fifteen Euphorbiaceae Plant Extracts

Abd‐Alla¹,

Sweelam²,

El‐Kashak³

et al. 2019

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Objective: Fifteen Euphorbiaceae plant extracts were evaluated for their antiviral and immune boosting properties. Methods: The maximum non-toxic concentration of each extract in specific pathogen-free embryonated chicken eggs was estimated and their antiviral efficacy was determined in terms of reduction in viral titers, measured by the hemagglutination inhibition (HI) assay. The antiviral efficacy was compared with ribavirin. The active extract was further subjected to estimation of total polyphenolic and flavonoid contents. Also, GC/ MS analysis was used to analyze its unsaponifiable and saponifiable matters. Results: The cytotoxic concentration fifty (CC 50 ) of Breynia distacha recorded the value of >200 and >300 for Newcastle disease virus (NDV) and avian influenza virus (AIV) H5N1, respectively. This extract showed antiviral inhibition concentration (IC 50 ) values of ≤ 2 and ≤ 3, respectively and antiviral therapeutic index of 100% compared with ribavirin as standard. The serum of the vaccinated chicks treated with B. distacha has recorded the highest HI titers (7.1 and 8.3 log2) at the day of 28 post vaccination with high protection percentage (100 and 90%) post NDV and AIV H5N1 challenge, respectively. Also, a high HI titer (6.9 log2) was recorded in serum of the vaccinated chicks treated with Aleurites moluccana, Jatropha curcas, Ricinus communis, Putranjiva roxburghii with protection percentage of 95-100% post-NDV challenge. GC/MS analysis allowed identification of 91.10% of the total unsaponifiable matter, (1-heptatriacotanol represented the major component, 24.61%) and 82.51% of the fatty acid methyl esters content (methyl palmitate represented the major component, 26.13 %). Conclusion: This study highlighted the potential of many Euphorbiaceae plants especially B. distacha, to be new candidate of plant-based prototypes that carry antiviral and immunogenic features against respiratory viral infections.has the potential of being more successful in its steps than screening of pure compounds isolated from the products. 8 The spurge family, Euphorbiaceae occupied a special place in the realm of plant families and is scientifically reported for its antiviral, antimicrobial, anticancer, cytotoxic, and antitumor activities. 9 In this respect, the present work aims to search for the use of plants of the Euphorbiaceae family to combat emerging infectious poultry diseases. Fifteen species belong to this family, are widely distributed and easily available throughout various geographical locations in Egypt, 10 were selected and subjected to evaluate their potential anti-viral activities against respiratory tract infection pathogens in specific pathogen-free (SPF) chicken embryos and evaluation of immune boosting properties of these substances in SPF chicks. These plant species are well known to have their traditional claims for cure and/or reduce symptoms of various disorders including infectious diseases of animal and human among folk cultures.

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“…Remarkable effective increases of the antibody titers, lymphocyte and macrophage cells, in blood were recorded. 17 …”

Section: Jatropha Curcas Lmentioning

confidence: 99%

Untitled

2016

IJPSR

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Herbal immunomodulator is substance which stimulates or suppresses the components of immune system including both innate and adaptive immune responses. The modulation of immune system by various medicinal plant products has become subject for scientific investigations currently worldwide. A number of Indian medicinal plants and various "Rasayana" have been claimed to possess immunomodulatory activity. Some of these plants are, Allium sativum, Morus alba, Acacia catechu, Tinospora cordifolia, and Mangifera indica. A lot more are still to be explored and offer scope for further investigation.

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Phytoconstituents of Jatropha curcas L. Leaves and their Immunomodulatory Activity on Humoral and Cell-Mediated Immune Response in Chicks

Cited by 48 publications

References 12 publications

Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Evaluation of Immune Boosting Properties and Combating of Multiple Respiratory Viral Infections by fifteen Euphorbiaceae Plant Extracts

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