Phytocosmeceutical formulation development, characterization and its in-vivo investigations

Mohammad, Imran Shair; Naveed, Muhammad; Ijaz, S.; Shumzaid, Muhammad; Hassan, Sidra; Muhammad, Kiran Sher; Rasool, Fatima; Akhtar, Naveed; Ishaq, Hafiz Muhammad; Khan, Haji Muhammad Shoaib

doi:10.1016/j.biopha.2018.08.024

Cited by 21 publications

(41 citation statements)

References 30 publications

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“…On each measurement day, volunteers were asked to wait for 30 minutes before taking readings for skin parameters so that the skin can assimilate with the indoor environmental condition of 25 ± 1°C and 40% RH (relative humidity). 13…”

Section: Methodsmentioning

confidence: 99%

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Assessment of changes in biophysical parameters by dermocosmetic emulgel loaded with Cinnamomum tamala extract: A split‐faced and placebo‐controlled study

Arshad

Khan

Akhtar

et al. 2019

J of Cosmetic Dermatology

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Background Phenolic and flavonoid compounds found in plants alleviate the photo‐damaging skin conditions by playing a major role in skin rejuvenation. Aims The aim of the study was to explore the cosmeceutical effects of Cinnamomum tamala extract. Objective Recent research was aimed to quantify phenols and flavonoids in the natural extract of C tamala leaves, to develop its phyto‐cosmetic emulgel and to assess effects of emulgel on healthy human skin. Method Phenols and flavonoids in C tamala (CT) extract were quantified by using ELISA assay. Emulgel formulation loaded with 4% C tamala (CT emulgel) was developed, and its cosmetic effects were evaluated on the cheeks of 13 healthy female test volunteers by comparing with placebo (base). Facial parameters including melanin, erythema, sebum, and visible facial pores (size and area) were studied by using Mexameter®, Sebumeter®, and VisioFace® at regular interval for 90 days. Results Total phenolic content and total flavonoids content of C tamala leaves extract were found to be 73.08 ± 0.0078 mg GAE/g and 52.63 ± 0.0060 mg QE/g CT extract respectively. As compared to placebo (base), CT emulgel was found to be significantly (P ≤ .05) effective in minimizing skin photo‐damaging effects by reducing the levels of melanin, erythema, and sebum and size and count of both fine and large facial pores. Conclusion Cinnamomum tamala leaves extract, being a rich source of phenols and flavonoids minimized the photo‐damaging effects by reducing skin melanin, erythema, and excess sebum; improving the skin imperfections by reducing facial pore count and area as assessed by advanced imaging and bioengineering techniques.

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Section: Methodsmentioning

confidence: 99%

“…An active emulgel was formulated by preparing oil in water emulsion first. 13 C tamala (CT) extract. Finally, by using the mechanical stirrer, this oil in water emulsion was incorporated into 1.5% carbopol gel base in 1:1 ratio.…”

Section: Preparation Of Herbal (Active) and Placebo Emulgelsmentioning

confidence: 99%

Assessment of changes in biophysical parameters by dermocosmetic emulgel loaded with Cinnamomum tamala extract: A split‐faced and placebo‐controlled study

Arshad

Khan

Akhtar

et al. 2019

J of Cosmetic Dermatology

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“…These results demonstrated the homotypic targeting ability. Cells basically have certain antigen receptors and proteins on their surface, which not only help them to maintain their normal physiological functions but also are responsible for inter-cellular and immunological crosstalk, whereas in cases of tumor cells, approximately 150 transmembrane proteins are overexpressed and have a potential to enhance internalization of materials [ 22 , 23 , 24 ]. Therefore, this higher uptake of A549/T CM-HNPs may be associated with the overexpressed certain membrane proteins on A549/T cells [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Homotype-Targeted Biogenic Nanoparticles to Kill Multidrug-Resistant Cancer Cells

Mohammad

Chaurasiya

et al. 2020

Pharmaceutics

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“Off-targeting” and receptor density expressed at the target sites always compromise the efficacy of the nanoparticle-based drug delivery systems. In this study, we isolated different cell membranes and constructed cell membrane-cloaked biogenic nanoparticles for co-delivery of antitumor paclitaxel (PTX) and multidrug resistance (MDR)-modulator disulfiram (DSF). Consequently, MDR cancer cell membrane (A549/T)-coated hybrid nanoparticles (A549/T CM-HNPs) selectively recognized the source cells and increased the uptake by ninefold via the homotypic binding mechanism. Moreover, the A549/T CM-HNPs sensitized MDR cells to PTX by suppressing P-glycoprotein (P-gp) activity by 3.2-fold and induced effective apoptosis (70%) in homologous A549/T cells. Cell-membrane coating based on the “homotypic binding” is promising in terms of promoting the accumulation of chemotherapeutics in MDR cells and killing them.

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“…It seems that this extract can act as a powerful antidote for helping people who have been bitten by this perilous snake [110]. Other studies reported that the concentrated emulsion of P. cineraria bark extract also shared potential benefit for improving facial skin properties [87]. In some parts of Asia, and especially in Pakistan, P. cineraria (Pci) (or queen of the desert) is renowned for its medicinal uses, and natives used various tissues of this plant for many proposes [111].…”

Section: Pre-clinical Effectiveness: Paving the Way For Clinical Studiesmentioning

confidence: 99%

“…Moreover, in vivo results revealed that the formulation (size 3 µm) reduced skin melanin, erythema and sebum contents up to 2.1-and 2.7-and 79%, while reduced the skin hydration and elasticity up to 2-folds and 22% than the base, respectively. Owing to increased therapeutic activity, the phytocosmetic formulation proved to be a potential skin whitening, moisturizer, anti-acne, anti-wrinkle, anti-aging therapy, besides to be able to stimulate skin rejuvenation and resurfacing [87] Anthelmintic Effects…”

Section: Anti-depressive and Cns Disorders Effectsmentioning

confidence: 99%

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

et al. 2019

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Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

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Phytocosmeceutical formulation development, characterization and its in-vivo investigations

Cited by 21 publications

References 30 publications

Assessment of changes in biophysical parameters by dermocosmetic emulgel loaded with Cinnamomum tamala extract: A split‐faced and placebo‐controlled study

Assessment of changes in biophysical parameters by dermocosmetic emulgel loaded with Cinnamomum tamala extract: A split‐faced and placebo‐controlled study

Homotype-Targeted Biogenic Nanoparticles to Kill Multidrug-Resistant Cancer Cells

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

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